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Product Name: Isavuconazole Sulfate
Chemical Formula: C22H17F2N5OS · H2SO4
Synonyms: No known synonyms in commercial use
CAS Number: 946075-13-4
Recommended Use: Pharmaceutical antifungal agent, laboratory chemical
Supplier Details: Manufacturer and distributor addresses, emergency contact number, and contact for technical questions provided on commercial labels and catalogs
Emergency Telephone: 24-hour emergency response services, local poison control centers
Import/Distribution Country: Specified per shipment documentation
Prepared by: Safety or compliance specialist’s department
Classification: Acute toxicity category (oral, inhalation), eye irritation category, skin sensitizer, reproductive toxicity classification based on animal data
Hazard Statements: May be harmful if swallowed, causes eye and skin irritation, respiratory effects from prolonged inhalation, repeated exposure at high doses may damage liver
Pictograms: Exclamation mark, health hazard, corrosive symbols
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, use personal protection, keep away from food and drink during handling, wash hands thoroughly after use, seek medical attention if symptoms develop
Other Hazards: No additional information for thermal decomposition, high dust concentrations in air cause irritation, non-flammable but possible dust explosion risk in powder
Chemical Name: Isavuconazole Sulfate
Content: Purity by weight typically above 95% for pharmaceutical grade
Impurities: Trace process impurities below 1%, not classifiable
Inert Ingredients: None intentionally present
Stabilizers or Preservatives: Absent in neat substance
Other Constituents: Only Isavuconazole Sulfate present in the container as purchased
General Advice: Remove from exposure, remain calm, avoid further contact
Eye Contact: Rinse cautiously with water for at least 10-15 minutes keeping eyelids open, remove contact lenses if present, seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing, consult a doctor if symptoms or rash appear
Inhalation: Move exposed person to fresh air, keep breathing comfortably, obtain medical attention if symptoms develop (coughing, difficulty breathing)
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel, seek medical advice if large quantities consumed
Notes for Doctor: Treat symptoms, support respiratory and cardiovascular function, symptomatic supportive care, consider risk of allergic reactions or effects on liver function
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Do not use high pressure water jet as this may spread powder
Special Hazards: Thermal decomposition produces oxides of carbon, nitrogen, sulfur, fluorinated compounds, toxic fumes
Protective Equipment: Firefighters to wear self-contained breathing apparatus, full protective gear
Specific Methods: Use water spray to keep containers cool, prevent runoff contamination, avoid inhaling combustion products
Explosion Data: No data for dust explosibility found at typical handling concentrations, avoid high dust formation
Hazards to Environment: Prevent fire-fighting run-off from entering drains, water courses
Personal Precautions: Evacuate unnecessary personnel, use protective clothing, avoid dust formation, ventilate area
Environmental Precautions: Prevent entry into sewers, drains, water sources using containment measures such as sand, absorbent barriers
Cleanup Methods: Collect powder using HEPA-filter vacuum or wet sweeping, do not dry brush, transfer waste to sealed container, decontaminate area with water and detergent
Disposal: Refer to section on Disposal Considerations, follow local regulations, label collected waste clearly
Notification Requirement: Report large spills to appropriate regulatory agency, document incident
Cleanup Personnel Protection: Appropriate respirator, nitrile gloves, protective eyewear or goggles, chemical protective clothing if necessary
Precautions for Safe Handling: Avoid contact with skin, eyes, and clothing, handle inside chemical fume hood if possible, avoid breathing dust, maintain good workplace hygiene
Storage Conditions: Store tightly closed in original container, dry, well-ventilated space, away from direct sunlight, moisture, incompatible substances (strong acids, strong oxidizing agents)
Hygiene Practices: Do not eat, drink, or smoke where material handled, wash thoroughly after use, keep containers clean and labeled
Packaging: Use leak-proof containers, support upright storage, evidence of tampering or damage to be reported
Other Handling Information: Limit access to authorized personnel, ensure safety data sheet available at handling site
Occupational Exposure Limits: No specific national or international workplace limits established, use pharmaceutical exposure banding (low microgram per cubic meter range)
Engineering Controls: Local exhaust ventilation, closed transfer systems, negatively pressured enclosures if available
Personal Protective Equipment (PPE): Disposable nitrile or chemical resistant gloves, protective laboratory coat, splash goggles, fitted respirator for airborne dust
Work Practices: Minimize dust generation, clean work surfaces regularly, keep personal items separate
Environmental Controls: Minimize releases, filter and treat exhaust air, avoid contamination of water
Appearance: Off-white to pale yellow powder
Odor: Odorless or faint chemical odor
Odor Threshold: Not determined
pH: Not applicable (solid powder), mild in water suspension
Melting Point/Range: Approximately 122–130 °C, decomposition may precede melting
Boiling Point: Not applicable for solid
Flash Point: Not determined, presumed not flammable
Flammability: Expected to be non-flammable, can form dust-air mixture risk
Explosive Properties: Fine powder, avoid dust clouds
Vapor Pressure: Not measurable at room temperature
Solubility: Soluble in DMSO, slightly soluble in water
Partition Coefficient (log Pow): Moderately lipophilic
Auto-ignition Temperature: Not self-igniting below 400°C
Density: Approximately 1.35 g/cm³
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended conditions of handling, storage, and normal temperatures
Reactivity: Limited reactivity, not reactive under recommended conditions
Incompatible Materials: Strong oxidizing agents, strong acids, bases liable to hydrolyze or decompose
Hazardous Decomposition: Decomposes on burning to produce toxic gases: COx, NOx, SOx, fluorine-containing chemicals
Polymerization: No risk of polymerization under standard handling
Other Information: Avoid high temperatures, moisture, excessive mechanical impact
Route of Exposure: Inhalation, oral, dermal
Acute Toxicity: Animal LD50 (rat, oral) above 1000 mg/kg; slight irritation on skin and eyes
Chronic Toxicity: Animal tests: chronic exposure linked to mild blood chemistry changes, potential liver effects at high doses
Sensitization: No evidence of skin or respiratory sensitization in limited tests
Mutagenicity: Negative in most standard bacterial and mammalian test systems
Carcinogenicity: No classification based on animal data, not listed by IARC/NTP/OSHA as carcinogen
Reproductive Toxicity: Animal studies: evidence of fetal toxicity only at maternally toxic doses
Target Organ Effects: Liver, blood, possible mild kidney impact at high repeated doses
Eco-Toxicity: Not highly toxic to aquatic species, but limited data, avoid contamination of waterway
Persistence and Degradability: Compound shows moderate persistence, slow degradation in water and soil
Bioaccumulation: Moderate bioaccumulation potential
Mobility in Soil: Mobile in water under certain conditions, may bind weakly to soil particles
Other Effects: Avoid large-scale environmental releases, possible effects on aquatic plants and microfauna with continual exposure
Regulatory Agency Values: None established, not classified as aquatic hazard under GHS
Waste Disposal: Treat as hazardous pharmaceutical waste, incinerate in licensed chemical waste incinerator
Container Disposal: Triple rinse, deface label, dispose in accordance with local regulations
Other Precautions: Do not release to environment, avoid disposal to sewer, never reuse containers
Regulatory Notes: Follow local, regional, national, and international regulations for disposal practices
Recommended Practice: Approval of disposal method according to environmental authority, maintain disposal records
UN Number: Not classified as dangerous goods under ADR, IATA, IMDG
Proper Shipping Name: Not regulated for ground, sea, or air transport
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions: Use sealed, labeled container, prevent movement during transport
Marine Pollutant: Not listed as marine pollutant
Transport Labeling: No special labeling required, standard pharmaceutical shipping practices apply
WHMIS Classification (Canada): Not classified as hazardous
OSHA Hazard: Not considered hazardous by US OSHA criteria for labeling
EU Regulations: Not subject to classification under Regulation (EC) No 1272/2008, not listed on Annex XIV or SVHC
TSCA Status (USA): Not listed
REACH Status (EU): Exempt for medicinal products
GHS Label Elements: Not classified as hazardous under GHS global standards
Other International Regulations: Not subject to additional labeling in major economies for occupational handling (consult national EHS authorities)
