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Material Safety Data Sheet (MSDS) – Ioversol Hydrolysate

Identification

Product Name: Ioversol Hydrolysate
Chemical Family: Iodinated organic compounds
Synonyms: N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)glycyl]-2,4,6-triiodoisophthalamide hydrolysate
Use: Contrast agent precursor, research chemical
Manufacturer: [Insert Name]
Contact Information: [Insert Address, Phone, Emergency Number]
CAS Number: 87771-40-2

Hazard Identification

Classification: Non-flammable liquid, causes moderate eye and skin irritation, mildly hazardous to aquatic life
GHS Label Elements: Exclamation mark for irritant
Acute Health Effects: Slight irritation to skin, redness or burning in eyes, mild respiratory discomfort if inhaled
Chronic Health Effects: Prolonged skin contact may cause dryness or cracking, no known carcinogenic risk
Environmental Effects: Avoid uncontrolled release to surface water

Composition / Information on Ingredients

Chemical Identity: Ioversol Hydrolysate
Concentration: 98-100%
Hazardous Components: Ioversol, impurity profile includes less than 1% decomposition products
Additives: No known stabilizers or preservatives present

First Aid Measures

Inhalation: Move to fresh air, seek medical advice if coughing, dizziness, or chest pain occurs
Skin Contact: Wash area with soap and water, remove contaminated clothing, seek help if irritation persists
Eye Contact: Rinse eyes gently with water for 15 minutes, hold eyelids open, consult a physician if symptoms develop
Ingestion: Rinse mouth, drink water if conscious, never induce vomiting, seek immediate medical attention
Symptoms to Watch For: Itching, burning sensations, throat tightness, difficulty breathing

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Do not use high pressure water streams
Specific Hazards: Decomposes when heated to produce iodine vapors, oxides of carbon and nitrogen
Special Protective Equipment: Use self-contained breathing apparatus, protective clothing, keep upwind
Firefighting Instructions: Cool containers with water, avoid runoff entering drains, collect contaminated water separately

Accidental Release Measures

Personal Protection: Wear chemical goggles, nitrile gloves, lab coat
Spill Procedures: Absorb with inert material (sand, earth), collect in sealed container for disposal, ventilate area
Environmental Precautions: Prevent material from reaching drains, surface water, or soil
Clean-up Methods: Wash spill site after material pickup, avoid raising dust or aerosols, dispose of in compliance with local regulations

Handling and Storage

Handling: Use in well-ventilated areas, avoid inhalation and direct skin contact, wash hands after use, avoid eating or drinking around the substance
Storage: Keep in tightly closed container, store in a cool, dry, and well-ventilated place, avoid direct sunlight or sources of ignition, keep away from incompatible substances like strong acids or bases
Technical Measures: Install closed systems or local exhaust ventilation for bulk handling

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits, minimize exposure as a precaution
Engineering Controls: Use fume hood for laboratory work, maintain adequate general ventilation
Personal Protection: Chemical splash goggles, nitrile or neoprene gloves, lab coat, respiratory protection if mist is present
Hygiene: Remove contaminated clothing immediately, prevent contamination of personal items

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Odorless or faint chemical scent
pH: 5.5-7.5 at 20°C
Melting Point/Freezing Point: Below 0°C
Boiling Point: Decomposes above 190°C
Flash Point: Not applicable (non-flammable)
Solubility: Freely soluble in water, slightly soluble in ethanol
Density: 1.3-1.4 g/cm³ at 20°C
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log KOW): Less than 0, negligible bioaccumulation

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Avoid strong oxidizers, reducing agents, strong bases and acids
Hazardous Reactions: May produce hazardous fumes, including iodine vapors on decomposition
Incompatible Materials: Iron, copper alloys, ammonia
Decomposition Products: Iodine, carbon monoxide, carbon dioxide, nitrogen oxides

Toxicological Information

Acute Toxicity: Low acute oral and dermal toxicity in animal studies
Skin Contact: May cause mild irritation, not classified as skin sensitizer
Eye Contact: May produce redness, watering, and irritation
Inhalation: Mild irritation possible in case of mist exposure
Repeated Dose Toxicity: No evidence of delayed or chronic effects in limited studies
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No mutagenic activity in bacterial or mammalian systems
Reproductive Effects: No known reproductive hazards from hydrolysate exposure

Ecological Information

Environmental Effects: Product readily degrades, low persistence in environment
Fish Toxicity: LC50 >100 mg/L (low acute aquatic toxicity)
Algal Toxicity: EC50 >100 mg/L
Bacterial Inhibition: No effect at environmentally relevant concentrations
Bioaccumulation Potential: Insignificant, compound is water-soluble and not lipophilic
Mobility: Product disperses rapidly in water, low potential for soil adsorption

Disposal Considerations

Waste Disposal: Treat as chemical waste under local regulations, incineration at approved facility recommended
Container Disposal: Rinse containers, puncture or crush to prevent reuse, dispose with laboratory waste
Special Precautions: Do not discharge into surface water, storm sewer, or soil
Regulatory Compliance: Follow all applicable federal, state, and local environmental control regulations

Transport Information

UN Number: Not regulated for land, air, or sea shipment
Proper Shipping Name: Not dangerous goods
Hazard Class: Non-hazardous
Packing Group: Not assigned
Labeling: No specific transport labeling required, follow general safety labeling

Regulatory Information

US Regulations: Not listed as hazardous by OSHA or SARA Title III Section 313, not subject to TSCA restrictions
EU Regulations: Not classified as hazardous under CLP Regulation (EC) 1272/2008, no specific REACH restrictions
Canada: Not regulated as hazardous under WHMIS
Japan: Not subject to Poisonous and Deleterious Substances Control Law
Other: Product not subject to export control restrictions or international bans, general duty of care applies to handling and disposal