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Product Name: Iohexol
Chemical Name: N,N'-Bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodoisophthalamide
CAS Number: 66108-95-0
Recommended Use: Contrast media for radiographic imaging and research; laboratory reagent
Supplier Information: Contact local distributor or manufacturer referenced on original packaging
Emergency Contact: See local safety directory or supplier’s emergency line
Synonyms: Omnipaque
Formula: C19H26I3N3O9
UN Number: Not classified as hazardous for transport
Hazard Classification: Not classified as hazardous under GHS regulation; may cause mild irritation to eyes, skin, or respiratory tract on direct contact
Signal Word: Not applicable
Hazard Statements: May cause slight skin or eye irritation; rarely linked to hypersensitivity reactions in susceptible individuals
Precautionary Statements: Avoid breathing vapors, dust, or spray; wash thoroughly after handling; wear suitable protection
Potential Health Effects: Eyes—irritation, redness; Skin—mild discomfort, possible rash with repeated exposure; Inhalation—transient irritation; Ingestion—potential upset stomach, unlikely toxicity at low doses
Environmental Hazards: Not classified as environmentally hazardous, but avoid uncontrolled release into soil and waterways
Ingredient: Iohexol
Concentration: ≥98%
Impurities: Minor process-related solvents or byproducts (manufacturer-dependent); none classified as hazardous
Stabilisers or Additives: None typically present
Molecular Weight: Approximately 821.14 g/mol
Eye Contact: Rinse immediately with plenty of water for at least 10-15 minutes; keep eyelids open and seek medical attention if irritation persists
Skin Contact: Wash affected skin thoroughly with soap and water; remove contaminated clothing
Inhalation: Move to fresh air immediately; provide oxygen if breathing difficulty develops; seek medical help if coughing or respiratory symptoms persist
Ingestion: Rinse mouth; drink plenty of water; do not induce vomiting unless instructed by medical personnel; seek medical advice especially for large amounts or persistent symptoms
Most Important Symptoms/Effects: Redness or irritation of eyes/skin; mild gastrointestinal upset following ingestion; rare allergic response
Special Advice for First Responders: Wear gloves and eye protection
Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or foam; water spray to cool surfaces
Unsuitable Extinguishing Media: No specific incompatibilities reported
Specific Hazards: Decomposition may produce toxic iodine, hydrogen iodide, oxides of carbon and nitrogen
Fire-Fighter Protection: Full protective clothing and self-contained breathing apparatus recommended
Special Procedures: Prevent runoff from entering drains; ventilate area for smoke and fumes
Personal Precautions: Wear appropriate gloves, eye protection, and lab coat; avoid dust formation and inhalation; ensure proper ventilation
Environmental Precautions: Prevent entry into drains, soil or surface water
Spill Containment: Absorb small spills with inert material such as sand or vermiculite; scoop up and place in a secure waste container
Cleanup Methods: Wash spill site with water after material collection; dispose of cleaning materials as chemical waste
Notification Procedures: Report major spills to local authorities as required
Handling: Avoid inhaling dust or vapors; minimize exposure by using in a chemical fume hood; avoid skin and eye contact; do not eat, drink, or smoke near the chemical; clean spills promptly
Storage: Store in a tightly sealed original container in a cool, dry place; keep away from direct sunlight, heat sources, and incompatible chemicals such as strong acids and bases; safeguard against freezing or extreme temperatures
Technical Measures: Use only with appropriate ventilation; keep containers upright and tightly closed to avoid leaks
Exposure Limits: No occupational exposure limits established for Iohexol
Engineering Controls: Use local exhaust or laboratory fume hood; implement safety eyewash stations and emergency showers
Personal Protective Equipment: Eye protection (goggles or safety glasses); skin protection (nitrile gloves and lab coat); respiratory protection if dust or aerosol formation likely
Hygiene: Wash hands thoroughly after handling; avoid contamination of personal clothing; restrict food and drink in the laboratory area
Environmental Controls: Prevent spillage or uncontrolled release; treat all waste as hazardous unless verified otherwise
Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Melting Point: Typically above 170°C
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in water, poorly soluble in most organic solvents
pH (solution): Neutral to slight acidity in aqueous solutions (5.5-7.5)
Flash Point: Not applicable
Vapor Pressure: Negligible
Density: Approximately 2.1 g/cm³ (solid)
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage and use conditions
Reactivity: Unreactive in normal laboratory or storage settings
Conditions to Avoid: High temperatures, direct sunlight, moisture, incompatible chemicals including strong acids, bases, and oxidizers
Hazardous Decomposition Products: Iodine, hydrogen iodide, oxides of nitrogen and carbon upon thermal decomposition or combustion
Polymerization: Not expected to occur
Incompatibility: Strong acids, bases, and powerful oxidizers; may react with reducing agents
Acute Toxicity: Low oral, dermal, and inhalation toxicity in available studies; reported LD50 (oral, rat) above 5000 mg/kg
Skin Corrosion/Irritation: Slight, if any, observed on direct contact
Serious Eye Damage/Irritation: Minor, reversible irritation possible
Respiratory or Skin Sensitization: Rare allergic reactions (hypersensitivity) reported in medical use; unlikely in laboratory settings
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in standard studies
Target Organs: None identified under ordinary exposure
Additional Information: Prolonged exposure not recommended; standard precautions for laboratory chemicals advised
Ecotoxicity: Low to moderate toxicity in aquatic organisms based on structural similarity to other iodinated contrast media; not expected to bioaccumulate
Persistence and Degradability: Readily soluble; expected to be moderately persistent in water; likely to degrade over extended timeframes in environmental conditions
Mobility in Soil: High solubility may result in movement through soil with water; minimize uncontrolled discharges
Bioaccumulation Potential: Expected to be low
Other Adverse Effects: Large volumes may impact local microbial activity or aquatic life; never discharge concentrated solutions into the environment
Waste Disposal: Collect waste in tightly closed, labeled containers; dispose of through licensed chemical waste contractor or according to local environmental regulations
Product Disposal: Do not discharge into drains, surface water, or soil
Contaminated Packaging: Treat bottles, vials, or bags as chemical waste; rinse, if advised by waste authorities, and discard with controlled waste stream
Legal Requirements: Comply with national or regional hazardous waste laws and institutional protocols
UN Number: Not regulated under major dangerous goods codes (ICAO/IATA, IMDG, ADR/RID)
Proper Shipping Name: Not dangerous for transport
Transport Hazard Class: None assigned
Packing Group: None assigned
Special Precautions: Protect packages from moisture and physical damage; keep well sealed during handling and transport
Environmental Hazards: Avoid accidental releases
EC/CLP/GHS Classification: Not classified as hazardous
Chemical Inventory Status: Listed on relevant inventories such as US TSCA, EU REACH, Australia AICS, and Japan ENCS
Labeling Requirements: Follow institutional label and safety rules for laboratory chemicals
Other Local/International Rules: No specific restrictions identified, but always check updates to national chemical regulations and occupational health guidelines
SDS Effective Date: Refer to supplier documentation for latest revision; review and update SDS regularly according to local and international standards
