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Product Name: Iodixanol
CAS Number: 92339-11-2
Synonyms: Visipaque, 5-(N-(2,3-dihydroxypropyl)acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Recommended Use: X-ray contrast media in diagnostic imaging
Manufacturer: GE Healthcare or local distributor
Emergency Contact: Refer to national poison center or emergency response number
Classification: Not classified as hazardous under GHS (Globally Harmonized System)
Main Hazards: Non-flammable, low risk of acute toxicity, risk of allergic reaction after exposure, may cause minor irritation to eyes, skin, or if swallowed
Pictogram: None required under GHS, but awareness of potential mild health hazard is suggested
Signal Word: No signal word required
Chemical Name: Iodixanol
Concentration: Usually supplied as solution (270 mg Iodine/mL or 320 mg Iodine/mL in water)
Other Ingredients: Water for injection, sodium chloride, sodium calcium edetate, trometamol
Impurities: None significant, pharmaceutical grade compound
Mixture or Substance: Substance
Inhalation: Remove person to fresh air, seek medical attention if symptoms such as coughing, difficulty breathing develop
Ingestion: Rinse mouth, do not induce vomiting, contact physician for persistent symptoms
Skin Contact: Remove contaminated clothing, wash skin with plenty of water, consult doctor if irritation or allergic signs appear
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes, remove contact lenses if easy to do, contact eye specialist for persistent discomfort
Advice to Physician: Treat symptomatically, monitor for allergic reactions and acute renal failure
Suitable Extinguishing Media: Use water spray, dry powder, foam or carbon dioxide
Specific Hazards: Product does not burn easily, in a fire setting toxic iodine fumes may develop
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Firefighting Instructions: Move containers away from fire if safely possible, avoid inhalation of fumes, prevent contaminated water runoff
Personal Precautions: Avoid direct contact with skin, eyes, or clothing, ensure ventilation in area, use personal protective equipment
Environmental Precautions: Avoid discharge into sewers, surface and ground water, notify authorities if product enters environment
Methods for Cleaning Up: Absorb spill with inert material (sand, earth, or absorbent pads), place in closed container for disposal, wash spill area with water after removal
Disposal of Waste: Collect and dispose of waste in accordance with local regulations
Handling: Avoid spills, prevent inhalation, ingestion, or contact with skin and eyes, use only in well-ventilated areas, do not eat, drink or smoke while using
Storage Conditions: Store at controlled room temperatures (15–30°C), keep container tightly closed, protect from light, do not freeze, keep away from incompatible materials
Special Requirements: Keep out of reach of children, use original containers only, observe pharmaceutical handling guidelines
Occupational Exposure Limits: No threshold limit value established for Iodixanol
Personal Protective Equipment: Wear suitable gloves (nitrile or latex), protective lab coat or apron, safety goggles
Engineering Controls: Work in a well-ventilated area, use fume hood if available
Hygiene Measures: Wash hands thoroughly after handling, clean any exposed skin
Respiratory Protection: Not required under normal conditions; use approved respirator if aerosol or vapor exposure risk exists
Appearance: Clear, colorless to slightly yellow solution
Odor: Odorless
pH: 6.8–7.6
Melting Point/Freezing Point: Not applicable, aqueous solution
Boiling Point/Range: Approx. 100°C (water-based solution)
Flash Point: Not flammable
Solubility: Freely soluble in water
Specific Gravity: Approx. 1.3 at 23°C
Partition Coefficient: Not available
Viscosity: Higher than water (6.3–11.8 mPa·s at 37°C, depending on concentration)
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactions expected under normal conditions
Possibility of Hazardous Reactions: None under normal use
Materials to Avoid: Strong oxidising or reducing agents
Hazardous Decomposition Products: Iodine, carbon oxides (if heated to decomposition)
Routes of Exposure: Eye, skin, ingestion, inhalation (mists or aerosols)
Acute Toxicity: Low toxicity after single exposure, LD50 (oral, rat) > 5,000 mg/kg
Chronic Effects: No known chronic toxic effects, long-term effects rare in occupational settings
Potential Health Effects: May cause mild, temporary irritation to eyes or skin, risk of allergic reactions or rare anaphylactoid symptoms in sensitive individuals, accidental ingestion may lead to nausea or vomiting
Carcinogenicity: Not listed as carcinogenic by IARC, NTP or OSHA
Aquatic Toxicity: Not expected to be toxic to aquatic organisms, LC50 > 100 mg/L (fish, acute exposure)
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: Mobile in aqueous phase
Other Adverse Effects: Large releases could impact wastewater treatment, minimize environmental discharge
Disposal Methods: Dispose of contents and container in accordance with all local, regional, national, and international regulations
Waste Treatment: Follow requirements for pharmaceutical waste, avoid discharge into drains or natural waterways
Container Disposal: Rinse containers if required and discard according to official instructions
UN Number: Not regulated as a dangerous good
Proper Shipping Name: Not classified as hazardous
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Avoid physical damage to containers during transport, protect from extreme temperatures, ship in upright position
US Regulations: Not subject to TSCA, FDA regulated drug or device, not OSHA hazardous
EU Regulations: Registered as medicinal product, complies with Regulation (EC) No 1907/2006 (REACH) exemption for medicinal substances
Other National Regulations: Regulations may differ by country, always consult local regulatory bodies
Labeling Requirements: Label in accordance with local pharmaceutical and chemical safety laws
Global Inventories: Not listed in chemical inventories, managed as a pharmaceutical product
