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Product Name: Indomethacin Sodium
Chemical Formula: C19H15ClNO4Na
Synonyms: Indomethacin sodium salt, Methoxyindoleacetic acid sodium salt
CAS Number: 19819-47-3
Intended Use: Non-steroidal anti-inflammatory, pharmaceutical research
Manufacturer: Pharmaceutical suppliers, contract research labs
Contact Information: Address and emergency telephone number generally appear on label from the supplier
Recommended Restrictions: Professional use, not for general public or casual contact
Classification: Acute toxicity (oral, dermal, inhalation); Eye irritation; Reproductive toxicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed; Causes serious eye irritation; May cause damage to unborn child; Risk of organ damage through prolonged exposure
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust; Wear protective gloves, eye protection; Wash hands thoroughly after handling; Do not eat, drink or smoke during handling
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Target Organs: Liver, kidneys, reproductive organs
Potential Health Effects: Gastrointestinal upset, CNS symptoms, respiratory tract irritation, allergic reactions
Chemical Identity: Indomethacin Sodium
Purity: Typically >98%
Impurities: Traces of organic solvents, residual starting materials (<1%)
Other Components: No significant stabilizers or additives included in typical pure material
Mixtures: Not a mixture, single component substance
Inhalation: Remove person to fresh air; Seek medical attention if symptoms like difficulty breathing, cough, or headache persist
Skin Contact: Remove contaminated clothing; Wash area with soap and water for several minutes; Medical assessment for persistent irritation
Eye Contact: Rinse cautiously with water for at least 15 minutes while holding eyelids apart; Remove contacts if present; Immediate medical assessment required for persistent redness or pain
Ingestion: Rinse mouth; Do not induce vomiting; Never give anything by mouth to an unconscious person; Seek emergency medical care
Primary Symptoms/Effects: Nausea, abdominal pain, headache, dizziness, allergic skin or mucosal reactions
Suitable Extinguishing Media: Water mist, carbon dioxide, dry chemical powder, foam
Unsuitable Media: High-pressure water jets, direct stream risk causing spread
Hazards from Combustion: Combustion releases toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride
Special Protective Equipment: Full turnout gear and self-contained breathing apparatus recommended for firefighters
Additional Information: Move product containers from fire area if possible and safe; Cool exposed containers with water spray; Prevent runoff to drains or watercourses
Personal Precautions: Evacuate unnecessary personnel; Wear suitable protective clothing, gloves, and goggles; Use dust masks or respirators where powder dispersal risk occurs
Environmental Precautions: Avoid discharges to soil, sewers, surface waters; Alert environmental authorities if large spill threatens environment
Cleanup Methods: Sweep or scoop spilled material into suitable containers for disposal; Minimize dust formation; Wash area with water and detergent; Keep waste collected in closed, labelled containers for disposal as hazardous waste
Handling: Handle in well-ventilated spaces; Avoid creating dust; Do not breathe vapors or powders; Use only with appropriate protective equipment; Never eat, drink, or smoke while handling
Precautions: Prevent contact with eyes, skin, and clothing; Ensure strict hygiene standards; Minimize occupational exposure wherever possible
Storage Conditions: Keep container tightly closed in a cool, dry place; Protect from light, heat, moisture sources; Store away from incompatible chemicals, such as strong acids, oxidizers
Special Requirements: Dedicated pharmaceutical or chemical storage facilities preferred; Clearly label all containers and maintain inventory logs
Occupational Exposure Limits: No official global standards, recommend keeping as low as reasonably achievable
Engineering Controls: Work under fume hood or in controlled air-extraction environment; Use enclosures or local exhausts
Personal Protection: Safety glasses with side-shields or chemical goggles; Nitrile or neoprene gloves; Lab coat or chemical-resistant apron; Respiratory protection if airborne concentrations increase
Hygiene Measures: Wash hands after handling, before breaks, at end of shift; Remove contaminated clothing and wash before reuse; Avoid direct contact, especially to face and eyes
Appearance: White to off-white powder
Odor: Odorless or faint, characteristic odor
Odor Threshold: Not established
pH Value: 7–8 (1% aqueous solution)
Melting Point: 159–161°C
Freezing Point: Not determined
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (solid)
Evaporation Rate: Not applicable
Flammability: Not flammable, but combustible at high temperatures
Explosion Limits: Not determined
Vapor Pressure: Negligible
Vapor Density: Not applicable
Relative Density: About 1.49 g/cm³
Solubility: Soluble in water, ethanol, DMSO
Partition Coefficient (log Kow): Not established
Auto-ignition Temperature: No data available
Decomposition Temperature: >200°C
Viscosity: Not relevant
Chemical Stability: Chemically stable under recommended conditions, decomposes with heat above 200°C
Reactivity: Low chemical reactivity at room temperature; Avoid mixing with strong oxidizers or acids
Hazardous Reactions: Risk of hazardous decomposition with incompatible compounds; May evolve toxic gases (CO, NOx, HCl) under strong heat or fire
Avoided Conditions: Excessive heat, moisture, light exposure
Incompatible Materials: Strong oxidizing agents, concentrated mineral acids
Decomposition Products: Hydrogen chloride, carbon monoxide, nitrogen oxides, noxious organic fragments
Acute Toxicity: Harmful by ingestion, inhalation, or skin contact; LD50 (oral, rat) approximately 50 mg/kg
Skin Irritation: May cause mild to moderate irritation on prolonged or repeated exposure
Eye Damage: Serious eye irritation, possible corneal injury
Respiratory Sensitization: Cough, shortness of breath, dizziness likely if aerosols inhaled in quantity
Chronic Effects: Prolonged exposure associated with liver and kidney injury, risk of gastrointestinal bleeding, potential teratogenicity (risk to fetal development)
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity: Not identified as genotoxic in available in vitro or in vivo studies
Reproductive Toxicity: Embryotoxic, teratogenic potential in animal experiments; Not for use in pregnancy unless clearly needed
Ecotoxicity: Toxic to aquatic organisms; LC50 (fish) and EC50 (daphnia) values reflect moderate risk with concentrated spills
Environmental Fate: Not readily biodegradable; Persistence in water and soil likely
Bioaccumulation Potential: Possible due to moderate log Kow; Risk to food chain with repeated events
Mobility in Soil: Moderate; may migrate to groundwater in high solubility states
Other Hazards: Do not discharge into drains, water courses, or onto ground; Even small quantities disrupt aquatic habitats
Waste Disposal: Treat as hazardous pharmaceutical waste; Dispose of contents and container in accordance with local, regional, and national legislation
Recommended Disposal Methods: High-temperature incineration with flue-gas scrubbing; Avoid landfill where possible to prevent environmental release
Packaging Disposal: Empty containers retain residue; Triple rinse and offer for hazardous waste disposal
Avoidance: Do not discharge into water resources, public landfills, or regular trash collection
UN Number: Not classified as dangerous good by road (ADR), sea (IMDG), or air (IATA) for small quantities
Proper Shipping Name: Chemical, N.O.S. (contains Indomethacin Sodium)
Transport Hazard Class: Not regulated as hazardous
Packing Group: Not assigned
Marine Pollutant: Yes, must prevent release to marine environments
Special Precautions: Secure packaging against accidental release; Label all containers clearly; Emergency contact details must accompany shipment
International Inventories: Notified substance under REACH (EU), TSCA (US), DSL (Canada) based on research/laboratory use
Labeling Requirements: Must display hazard pictograms, risk and safety phrases in accordance with GHS
Occupational Health Regulations: Exposure must be controlled through engineering measures and PPE; Specific local standards may apply
Environmental Regulations: Subject to reporting and control for significant releases; Pharmaceutical discharge regulations apply in most jurisdictions
Workplace Controls: Documented risk assessments, formal staff safety training required in regulated facilities
Other Regulatory Lists: Not listed as controlled substance, but subject to prescription-only legislation in many countries; Not covered under major chemical weapons or controlled precursors conventions
