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Product Name: Indobufen
Chemical Name: 2-(4-(1-Oxoisoindolin-2-yl)phenyl)butanoic acid
Synonyms: Indobufene, Ibustrin
CAS Number: 63610-08-2
Recommended Use: Antiplatelet agent
Manufacturer Information: Refer to supplier for details
Emergency Telephone: Refer to local regulations or national poison centers
GHS Classification: Not classified as hazardous according to GHS criteria
Signal Word: None
Hazard Statements: May cause skin or eye irritation in sensitive individuals, avoid inhalation of dust
Precautionary Statements: Avoid breathing dust, wash exposed skin thoroughly after handling, wear protective equipment during handling
Potential Health Effects: Inhalation, ingestion, or skin contact may cause irritation, allergic reactions have been reported in some cases, symptoms might include headache, nausea, rash, or respiratory discomfort
Chemical Composition: Indobufen 98-100%
Impurities: Minor, typically less than 2% by weight, consult supplier for specific profiles
Molecular Formula: C19H15NO3
Molecular Weight: 305.33 g/mol
Inhalation: Move affected person to fresh air, seek medical attention if symptoms persist, administer oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical assistance for persistent irritation
Eye Contact: Flush with plenty of clean water for at least 15 minutes, keep eyelids open and apart, consult an ophthalmologist if discomfort continues
Ingestion: Rinse mouth with water, do not induce vomiting unless instructed by medical personnel, seek immediate medical attention
Important Symptoms and Effects: Redness, itching, irritation, gastric delusions, possible allergic response, provide all available safety data to medical responders
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides under combustion, dust can pose explosion risks with strong oxidizing agents
Firefighter Protection: Wear self-contained breathing apparatus (SCBA) and full protective equipment, evacuate area if necessary due to potential for hazardous decomposition
Special Procedures: Cool surrounding containers with water spray to prevent pressure build-up
Personal Precautions: Remove all sources of ignition, prevent formation of dust clouds, use protective gloves, goggles, and dust mask to avoid exposure
Environmental Precautions: Prevent contamination of soil, surface water, and drains, avoid dispersing material in air
Methods for Clean-Up: Sweep up and place in a suitable container for disposal, clean area with water and mild detergent after material pick-up, ventilate contaminated area
Reporting: Inform local environmental authorities if significant spillage occurs or if contaminating watercourses
Handling: Handle in a chemical fume hood or well-ventilated area, avoid breathing dust or direct contact with skin and eyes, use non-sparking tools and explosion-proof equipment, maintain good industrial hygiene
Storage: Store in tightly closed original containers, keep in a cool, dry, and well-ventilated place away from incompatible substances (oxidizers, acids), keep away from heat and direct sunlight, clearly label storage area with appropriate hazard warnings
Protective Measures: Use procedures to minimize exposure, ensure emergency eyewash and shower stations are nearby
Exposure Limits: No established occupational exposure limits for Indobufen, use general dust exposure limits as a reference (e.g., ACGIH: Total Dust 10 mg/m³)
Engineering Controls: Work in a fume hood, ensure local exhaust ventilation at points of dust generation
Personal Protective Equipment: Safety goggles or face shield, chemical-resistant gloves (nitrile, neoprene), impervious overalls or lab coat, dust mask or respiratory protection for high concentrations
Work Hygiene: Wash hands after handling, avoid eating or drinking in the work area, change soiled clothing frequently and launder before re-use
Exposure Monitoring: Conduct regular air monitoring in work environments prone to dust exposure
Appearance: White to off-white crystalline powder
Odor: Faint medicinal odor
Odor Threshold: Data not available
pH: Not applicable (insoluble in water)
Melting Point: 143–145°C
Boiling Point: Decomposes before boiling
Flash Point: Not data available, considered non-flammable under normal use
Evaporation Rate: Not determined
Flammability: Powder may form combustible dust concentrations in air
Vapor Pressure: Not relevant for solid
Vapor Density: Not applicable
Relative Density: 1.33 g/cm³
Solubility: Sparingly soluble in water, soluble in ethanol, methanol, DMSO
Partition coefficient n-octanol/water (log Kow): ~2.8
Auto-ignition Temperature: No data
Decomposition Temperature: >145°C
Viscosity: Not applicable
Chemical Stability: Stable under normal ambient and anticipated storage and handling conditions
Possible Hazardous Reactions: Avoid exposure to strong oxidizers, acids or bases which can lead to breakdown of molecule
Conditions to Avoid: Exposure to heat, flames, and damp or humid environments can accelerate decomposition
Incompatible Materials: Strong oxidizers (e.g., peroxides, permanganates), strong acids, bases
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, possibly toxic fumes
Routes of Exposure: Inhalation, ingestion, dermal contact, ocular exposure
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg; data suggest low acute toxicity
Skin and Eye Contact: May cause mild irritation, slight risk of sensitization in predisposed individuals
Respiratory Effects: Dust may cause respiratory tract irritation, coughing, and shortness of breath
Chronic Effects: Long-term exposure data limited; not classified as carcinogen, mutagen, or reproductive toxin but avoid chronic irritation
Symptoms: Gastrointestinal distress, headache, dizziness, skin rash or eye redness
Medical Conditions Aggravated by Exposure: Pre-existing asthma, skin disorders may worsen
Ecotoxicity: Not expected to be highly toxic; limited data for aquatic environments, potential concern for pharmaceutical contamination in waterways
Persistence and Degradability: Poorly biodegradable, may persist under certain environmental conditions
Bioaccumulation: Moderate (log Kow suggests potential for accumulation in aquatic organisms)
Mobility in Soil: Low solubility limits leaching, but persists in sediment
Other Adverse Effects: Chronic freshwater or marine exposure may impact non-target organisms, disposal to water system not recommended
Disposal Methods: Collect and place in suitable containers for chemical or pharmaceutical waste, incinerate under controlled conditions by licensed contractor
Precautions for Disposal: Prevent environmental contamination, avoid release to waterways or sewers
Unused Product: Treat as hazardous chemical waste, refer to local regulations for pharmaceutical disposal
Used Containers: Rinse thoroughly, dispose as per hazardous waste guidelines
UN Number: Not regulated for transport under international guidelines
Proper Shipping Name: Not assigned
Hazard Class: Not regulated
Packing Group: Not assigned
Marine Pollutant: Not classified as marine pollutant
Transport Precautions: Ship in well-labeled, sealed containers, avoid extreme temperatures or humidity during transport, provide SDS with shipment as good practice
Safety, Health and Environmental Regulations: Subject to pharmaceutical safety management under country-specific guidelines
OSHA Status: Not specifically listed as hazardous
TSCA: Not listed
EINECS/ELINCS: Notified in Europe
Other Specific Regulations: Handled under medicine and chemical laws, storage and labeling must comply with local/national requirements, user responsible for conformance with chemical handling standards
Labeling Requirements: Chemical name, hazard pictograms if required, supplier’s contact and precautionary statements must be visible on the container
REACH Status (Europe): Check with manufacturer for exact pre-registration status
