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Product Name: 1-Amino-2-Methylindoline Hydrochloride
Chemical Formula: C9H13N2•HCl
Synonyms: Indapamide Intermediate
CAS Number: 1000332-97-1
Recommended Use: Pharmaceutical intermediate for Indapamide synthesis
Supplier Information: Contact manufacturer for information and custom support channels
Emergency Telephone: Refer to manufacturer or local authority for emergency response
GHS Classification: Acute Toxicity (Oral, Category 4), Eye Irritation (Category 2A), Skin Irritation (Category 2)
Label Elements: Warning; exclamation mark symbol
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Precautionary Statements: Avoid dust formation, wear protective clothing, store locked up away from incompatible materials
Chemical Identity: 1-Amino-2-Methylindoline Hydrochloride
Concentration: ≥98% (w/w)
Impurities: Trace levels of related indoline derivatives; see supplier COA
Other Components: No significant stabilizers or additives
Inhalation: Remove person to fresh air, monitor for breathing difficulty, seek medical help if symptoms appear
Skin Contact: Remove contaminated clothing, wash with soap and water for at least 15 minutes
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, get immediate attention
Ingestion: Rinse mouth, do not induce vomiting, call a local poison control center or healthcare provider
Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or alcohol-resistant foam
Special Hazards: May release toxic fumes of nitrogen oxides, hydrochloric acid under combustion
Protective Equipment: Firefighters need self-contained breathing apparatus, protective clothing
Firefighting Instructions: Move containers from fire area if safe, avoid inhaling fumes, use water spray to cool exposed surfaces
Personal Precautions: Evacuate unprotected personnel, ventilate the area
Protective Equipment: Wear gloves, eye protection, lab coat, use dust mask or respirator for poor ventilation
Spill Methods: Avoid dust, collect using shovel or vacuum with HEPA filter, transfer to closed container for disposal
Environmental Precautions: Prevent spillage into drains, soil, water courses
Handling: Minimize generation and accumulation of dust, handle in fume hood or well-ventilated space, keep away from incompatible substances like oxidizing agents
Storage: Store tightly sealed in a cool, dry location, avoid exposure to direct sunlight and moisture, separate from food and feedstuffs, secure against unauthorized access
Exposure Limits: No established OSHA or ACGIH TLV values
Engineering Controls: Use process enclosure, local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves, splash-proof safety goggles, laboratory coat, NIOSH-approved respirator in dusty conditions
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke during use, remove contaminated clothing promptly
Appearance: Off-white to pale yellow solid powder
Odor: Slight characteristic
Odor Threshold: Not available
pH (1% solution): 3–5
Melting Point: 260-265°C (decomp.)
Boiling Point: Not applicable (decomposes)
Flash Point: Not available
Solubility: Soluble in water, methanol; slightly soluble in ethanol
Vapor Pressure: Not available
Density: Approximately 1.2 g/cm³
Partition Coefficient (log Kow): Not determined
Auto-Ignition Temperature: Not available
Decomposition Temperature: Above 260°C
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal conditions
Possibility of Hazardous Reactions: May react with strong oxidizing agents
Conditions to Avoid: Moisture, heat, incompatible chemicals
Hazardous Decomposition Products: Nitrogen oxides, hydrochloric acid fumes
Routes of Exposure: Ingestion, skin, eye, inhalation
Acute Toxicity: Harmful if swallowed; LD50 (oral, rat): estimated >300 mg/kg
Skin Irritation: Irritant to skin, may cause redness
Eye Irritation: Causes moderate to severe irritation
Chronic Effects: No long-term toxicological data available; handle with caution to avoid repeated exposures
Sensitization: Not expected to cause sensitization under normal handling
Carcinogenicity/Mutagenicity: No data indicating potential to cause cancer or genetic defects
Ecotoxicity: No specific data for aquatic or terrestrial organisms; treat as potentially hazardous
Persistence & Degradability: Not readily biodegradable; risk of persistence in the environment
Bioaccumulation Potential: Low expected mobility based on water solubility profile
Mobility in Soil: No data, but high solubility indicates potential for migration if released
Other Adverse Effects: Prevent product from entering waterways or drains, impact not well studied
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations
Product Disposal: Transfer to authorized chemical waste disposal facility, avoid landfill disposal
Contaminated Packaging: Triple rinse containers before disposal, offer for recycling if available
Special Precautions: Do not release into the environment, keep residues separate from nonhazardous waste
UN Number: Not assigned for this substance
Proper Shipping Name: Chemical, n.o.s. (not otherwise specified)
Transport Hazard Class: Not classified as dangerous under ADR/RID/IMDG/IATA standards
Packing Group: Not regulated
Environmental Hazards: Not identified as a marine pollutant
Special Precautions: Keep containers tightly closed, upright, and secure during transport
OSHA Status: Not specifically regulated, general chemical safety required
TSCA Status: Subject to reporting if imported or manufactured in the USA
EU Regulations: Not listed on Annex VI of CLP; safety data sheet required for workplace use
SARA Title III: Not listed under Sections 302, 313
REACH: Exempt as intermediate for research or pharmaceutical production, pre-registration advised
Other National/Regional Regulations: Subject to chemical management regulations; keep up with local legislative changes
