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Product Name: Idoxuridine
Chemical Name: 5-Iodo-2'-deoxyuridine
CAS Number: 54-42-2
Molecular Formula: C9H11IN2O5
Recommended Use: Antiviral drug, research applications, pharmaceutical formulation
Supplier Information: Company address, emergency contact phone numbers, routine contact phone numbers for technical service, fax, email for safety data inquiries
Relevant Identified Uses: Laboratory R&D, medical use under prescription, not for unregulated consumer use, use in compliance with local requirements
Synonyms: IDU, Iododeoxyuridine
Hazard Classification: Acute toxicity (oral, dermal, inhalation), serious eye irritation, skin irritation, suspected of causing cancer, specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed, contact may cause eye and skin irritation, suspected carcinogenic potential, may affect cytotoxic and reproductive systems, harmful to aquatic organisms
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Wear protective gloves, prevent skin and eye exposure, do not ingest, avoid inhalation, wash thoroughly after handling, use in well-ventilated spaces, keep away from incompatible materials
Other Hazards: May aggravate pre-existing conditions involving the liver, bone marrow, or immune system
Chemical: Idoxuridine
CAS Number: 54-42-2
Percentage: Over 97% (pure powder), balance is unspecified impurities or water of hydration for crystalline forms
Impurities: No hazardous impurities above relevant thresholds
Molecular Weight: 354.1 g/mol
Inhalation: Move person to fresh air, support breathing, provide oxygen if needed, seek medical attention for symptoms like coughing, respiratory discomfort, or chest pain
Skin Contact: Remove contaminated clothing, rinse exposed skin with plenty of water and soap, monitor for irritation or rash, call a doctor for persistent symptoms
Eye Contact: Rinse eyes with water for 15 minutes, keep eyelids open, remove contact lenses, call an eye specialist if redness or pain continues
Ingestion: Rinse mouth, do not provoke vomiting, drink water only if conscious, seek immediate medical assistance, provide product label to healthcare provider
General Notes: Medical monitoring may be prudent for multiple routes of exposure, provide information on symptoms to treating physician, treat symptomatically
Suitable Extinguishing Media: Water spray (fog), dry chemical powder, alcohol-stable foam, carbon dioxide
Unsuitable Media: Direct water jets can spread powder, avoid using high-pressure streams
Specific Hazards: Emits toxic fumes of iodine, oxides of nitrogen, and carbon oxides when heated or burned
Protective Equipment: Use self-contained breathing apparatus, wear full protective gear including chemical-resistant suit, avoid breathing vapors
Advice for Firefighters: Approach upwind, prevent run-off water from contaminating drains or watercourses, cool containers exposed to fire, remove remaining material from area if safe
Personal Protection: Gloves, goggles, protective clothing, face shield if splashing possible, use appropriate respirator if dust is generated
Environmental Precautions: Prevent spillage from entering water systems, soil, or sewers, inform authorities if environmental contamination takes place
Containment & Clean-Up: Use non-sparking tools, collect spillage with damp disposable material, place in sealable container, decontaminate area with detergent and water
Disposal: Dispose according to local laws, incinerate in designated facility, collect remains in labeled hazardous waste container
Other Actions: Remove unprotected persons from area, ventilate area to avoid buildup of dust or vapor
Handling: Wear suitable PPE, avoid contact with skin, eyes, clothing, wash hands after use, handle in fume hood if available, use dust extraction equipment
Storage Conditions: Store tightly closed in original container, in a cool, dry, well-ventilated place, away from incompatible substances (strong oxidizers, acids, alkali), avoid direct sunlight and humidity
Incompatibilities: Store separately from food, animal feed, and unprotected personnel
Specific Requirements: Keep away from sources of ignition, prevent static build-up, no smoking near storage area
Packaging: Use shatterproof, leak-proof containers with clear labeling for hazard identification and transport
Exposure Limits: No established OSHA or ACGIH exposure limits; practice good industrial hygiene standards
Engineering Controls: Local exhaust ventilation, safety shower and eye wash station accessible, use in chemical fume hood
Personal Protective Equipment: Chemical-resistant gloves (e.g., nitrile), laboratory coat or coveralls, safety eyewear with side shields, respiratory protection if inhalation risk exists (approved mask or respirator)
Hygiene Practices: Remove contaminated clothing, avoid eating/drinking/smoking during use, wash hands before breaks and after use, launder clothes regularly
Environmental Protection: Prevent residue from entering drains or environment, use spill containment protocols
Appearance: White to off-white crystalline powder
Odor: No significant odor
Solubility: Slightly soluble in water, more soluble in dimethyl sulfoxide and basic solutions
Melting Point: Around 163–164°C
Boiling Point: Not applicable (decomposes)
Density: Approximately 2.36 g/cm³
pH: Not applicable for dry powder
Other Properties: Stable under recommended storage, light and moisture sensitive, may decompose with strong heat to release iodine vapors
Chemical Stability: Stable under normal handling, avoid conditions that generate substantial heat, avoid exposure to moisture and light
Reactivity: Does not undergo violent reactions under normal use
Incompatible Materials: Strong oxidizers, strong acids, strong bases, reducing agents
Hazardous Decomposition: Iodine, corrosive vapors, nitrogen oxides, carbon oxides formed upon burning or rapid decomposition
Polymerization: Not known to polymerize under standard conditions
Routes of Exposure: Inhalation, skin/eye contact, ingestion
Acute Toxicity: Harmful in large oral amounts (may cause nausea, headache, GI upset), irritation of airways or skin with contact
Chronic Effects: Evidence of carcinogenic risk in animal studies at high doses, may suppress bone marrow, can affect reproductive cells, reported mutagenic activity
Symptoms: Headache, fatigue, cough, dermatitis, eye burn
Delayed/Immediate Effects: Potential delayed effects on immune, blood, reproductive systems
Carcinogenicity Listings: Not classified by IARC, NTP, or OSHA, but listed as a potential mutagen
Other Health Info: Overexposure can exacerbate pre-existing conditions involving liver, blood, or immune organs
Aquatic Toxicity: Harmful to aquatic life, may bioaccumulate in aquatic systems, persistence likely in water bodies
Mobility: Low vapor pressure reduces risk of air dispersion, moderate soil binding, moderate migration in water possible
Biodegradability: Not readily biodegradable; decomposition in the environment may be slow
Other Effects: No known significant effects on birds or mammals at environmental exposures
Precautions: Prevent discharge to waterways, soil, groundwater, avoid mass release from labs or facilities
Methods of Disposal: Treat as hazardous laboratory or pharmaceutical waste, incinerate in accordance with regional, national, and local laws, do not landfill bulk unused material
Contaminated Packaging: Triple-rinse and offer for incineration, avoid recycling contaminated packaging
Special Procedures: Seek licensed disposal contractor with experience in pharmaceutical waste, label all containers securely and accurately
Local Restrictions: Follow statutes for hazardous waste, shipment, and destruction, document all transfers and disposals for compliance
UN Number: Not assigned for Idoxuridine as a standalone pharmaceutical
Transport Hazard Class: Not regulated by ADR/RID, IMDG, IATA for small laboratory quantities, larger shipments may be subject to special provisions
Packing Group: No assigned packing group for clinical-research quantities, bulk transport as hazardous chemical may trigger additional rules
Environmental Hazards: Handle as hazardous for aquatic environment if spilled, prevent release during loading/unloading
Special Precautions: Label packages with appropriate hazard and handling marks, provide emergency shipping instructions to carrier
OSHA: Not specifically listed as a hazardous chemical, apply general laboratory safety standards
TSCA: Listed
REACH/CLP: Not registered for large-scale use in EU, restricted to licensed pharmaceutical and laboratory users
DSL/NDSL (Canada): May be listed
Other Local Regulations: Comply with chemical substance registries for country or territory of use, abide by pharmaceutical/medical laws in country, report incidents as required
Worker Protection: Training, health surveillance for long-term handlers, access to safety data at point of use
