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Product Name: Ibuprofen
Chemical Name: (±)-2-(p-Isobutylphenyl) propionic acid
Common Names: Advil, Motrin, Nurofen
CAS Number: 15687-27-1
Recommended Use: Analgesic, Nonsteroidal anti-inflammatory drug (NSAID)
Manufacturer: Information supplied by pharmaceutical companies and chemical suppliers
Contact Information: Refer to supplier or local distributor for emergency telephone number and contact details
Formula: C13H18O2
Synonyms: Ibuprofenum, 2-(4-Isobutylphenyl)propionic acid
GHS Classification: Acute oral toxicity: Category 4, Eye irritation: Category 2, Specific target organ toxicity (repeated exposure): Category 2
Label Elements: Warning pictogram, Signal word: Warning
Hazard Statements: Harmful if swallowed; Causes serious eye irritation; May cause damage to organs through prolonged or repeated exposure
Routes of Entry: Inhalation, skin and eye contact, ingestion
Effects of Exposure: May cause gastrointestinal irritation, nausea, vomiting, drowsiness, skin or eye irritation at high concentrations or prolonged contact
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area
Component: Ibuprofen
Concentration: >98% by weight (pure substance); tablet or suspension formulations contain excipients and fillers
Excipients: May include lactose, microcrystalline cellulose, magnesium stearate, starch, silica (select according to finished product)
Impurities and Stabilizing Additives: None present in hazardous concentrations under normal use
Molecular Weight: 206.29 g/mol
General Advice: Move exposed person to fresh air; seek medical attention if symptoms persist
Inhalation: Remove to fresh air, monitor for respiratory symptoms, seek medical advice if unwell
Skin Contact: Remove contaminated clothing, wash skin with soap and water; see doctor if irritation develops
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; see ophthalmologist if irritation remains
Ingestion: Rinse mouth thoroughly, do not induce vomiting; consult poison control or seek medical aid
Symptoms After Exposure: Stomach upset, headache, dizziness, respiratory irritation, anxiety, visual disturbance, allergic reaction in sensitive individuals
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide (CO2)
Unsuitable Media: High-pressure water streams may scatter powder
Specific Hazards: During combustion, emits toxic fumes of carbon monoxide, carbon dioxide, and potentially irritating vapors
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Firefighting Instructions: Use water spray to cool exposed containers and prevent dust formation
Hazardous Combustion Products: Carbon oxides, irritating organic fumes
Personal Precautions: Avoid dust generation, provide adequate ventilation, use appropriate PPE such as gloves, goggles, and dust mask
Environmental Precautions: Keep out of drains, watercourses, and soil; inform authorities in event of large leak
Methods for Clean-up: Sweep up spills and place in suitable labeled waste container; avoid creating dust, wash spill area with water after material pickup
Disposal: Collect carefully to prevent airborne dust, and dispose of in compliance with local, state, and federal regulations
Precautions for Safe Handling: Minimize dust formation, avoid breathing dust, practice good industrial hygiene
Storage Conditions: Keep container tightly closed in a cool, dry, well-ventilated area; protect from light, heat, and moisture
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Special Requirements: Store away from foodstuffs, keep out of reach of children, label containers properly
Exposure Limits: No specific limits established for ibuprofen; consider general dust exposure limits (OSHA PEL: 15 mg/m³ total dust, 5 mg/m³ respirable fraction)
Engineering Controls: Work in well-ventilated area, use local exhaust ventilation if available
Personal Protection: Wear chemical-resistant gloves, safety goggles, dust mask or respirator, protective work clothing
Hygiene Measures: Wash hands after handling, remove contaminated clothing and wash before reuse
Appearance: White crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: 3-4 (aqueous suspension, 1% solution)
Melting Point: 75-78°C
Boiling Point: Decomposes
Flash Point: Not flammable but may burn at high temperature
Solubility: Practically insoluble in water (<1 mg/mL), soluble in ethanol, methanol, acetone
Partition Coefficient (log Pow): 3.97 (octanol/water)
Vapor Pressure: Not significant at room temperature
Bulk Density: Varies with crystal form, typically around 0.3–0.5 g/cm³
Chemical Stability: Stable under normal ambient and anticipated storage conditions
Reactivity: No specific reactivity hazards under normal conditions
Conditions to Avoid: Contact with incompatible materials, excessive heat, direct sunlight, moisture
Incompatible Materials: Strong oxidizing or reducing agents, strong acids or bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, various organic vapors upon combustion
Polymerization: Does not occur
Acute Toxicity: Oral LD50 (rat): 636 mg/kg; Inhalation or dermal routes less relevant due to low volatility and low dermal absorption
Chronic Effects: Prolonged excessive use can cause gastrointestinal bleeding, ulceration, renal and hepatic toxicity, increased risk of cardiovascular events
Skin/Eye Sensitization: May cause irritation but not considered a skin sensitizer for most individuals
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Negative in standard in vitro and in vivo assays
Developmental/Reproductive Toxicity: High doses may affect fetal development and should be avoided in late pregnancy
Ecotoxicity: Harmful to aquatic life at high concentration; LC50 (Daphnia magna, 48h): 21 mg/L
Persistence and Degradability: Moderately persistent; partial degradation in soil and water via microbial action
Bioaccumulative Potential: Low potential for bioaccumulation (log Pow <4)
Mobility in Soil: Limited due to poor water solubility, some mobility possible with suspended solids
Other Effects: Pharmaceuticals may disrupt aquatic organisms at low concentrations if released continually into waterways
Waste Treatment Methods: Dispose of through authorized chemical waste collector; incinerate in compliance with local, state, and federal regulations
Product Disposal: Do not discharge into drains or the environment; dispose as hazardous waste
Contaminated Packaging: Treat as hazardous; clean before recycling or dispose of as waste
Disposal Restrictions: Do not attempt disposal in municipal landfill or sewage due to environmental and health risks
UN Number: Not regulated by international transport as dangerous good
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Special Precautions for Transport: Protect from excessive vibration, moisture, and direct sun; keep tightly packed
Environmental Hazards: Prevent spillage during transport
Transport Labels: Standard shipping labels for chemical substances
U.S. Regulations: Ibuprofen is not listed as a hazardous substance under CERCLA or SARA but is regulated for workplace safety by OSHA chemical standards
EU Regulations: Not classified as dangerous under 67/548/EEC or 1272/2008 (CLP) for environmental or physical properties, subject to REACH requirements for pharmaceutical substances
International Inventory Status: Listed on TSCA, EINECS, DSL, AICS, ENCS, PICCS, and other relevant inventories
Other Regulations: Subject to prescription drug controls, local workplace safety standards, and wastewater discharge regulations; reference local and national guidelines for pharmaceutical workplace safety and environmental management
