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Product Name: Hygromycin B
Chemical Name: Hygromycin B
CAS Number: 31282-04-9
Recommended Use: Selective antibiotic for use in molecular biology, cell culture, and biotechnology applications
Manufacturer: Supplier information appears on the container label
Emergency Contact: Local Poison Control Center, Emergency response call numbers on supplier label
GHS Classification: Acute toxicity (health hazard), eye and skin irritation, possible mutagenic effects
Signal Word: Danger
Hazard Statements: Harmful if swallowed, harmful in contact with skin, may cause genetic defects, may cause damage to organs with prolonged exposure
Pictograms: Exclamation mark (irritant), Health hazard (mutagenicity)
Precautionary Statements: Avoid direct contact, do not breathe dust, wash hands thoroughly after handling, use personal protective equipment, in case of accident call a poison center or doctor
Chemical: Hygromycin B
Common Name: Hygromycin, antibiotic
Purity: Typically >90% active compound
Other Ingredients: Trace water and buffering agents, depending on manufacturing source
CAS Number: 31282-04-9
EC Number: 250-545-5
Hazardous Components: Hygromycin B only at significant concentrations
Inhalation: Move to area with fresh air, seek medical attention if symptoms like coughing, headache, or shortness of breath develop
Skin Contact: Rinse skin thoroughly with soap and water, remove contaminated clothing, contact healthcare provider for irritation or sensation
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, consult medical professional if redness, pain, or blurred vision occurs
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, seek immediate medical advice
Most Important Symptoms: Allergic reactions, gastrointestinal discomfort, respiratory irritation, possible delayed effects from chronic exposure
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes
Special Protective Equipment: Self-contained breathing apparatus and complete protective clothing
Specific Hazards: Powder may form explosive dust-air mixtures in confined or unventilated spaces
Firefighting Instructions: Cool surrounding containers, keep away from ignition sources, evacuate non-essential personnel
Personal Precautions: Wear gloves, lab coat, safety goggles, and suitable mask
Environmental Precautions: Prevent runoff, avoid entry into water systems or soil
Cleanup Methods: For small spills, sweep up with disposable towel or vacuum using HEPA filter; for larger spills, contain powder, collect into sealed container for disposal
Procedures for Handling Dust: Use wet methods if possible to minimize dust generation
Decontamination: Wash affected area with soap and water following cleanup
Precautions for Safe Handling: Avoid breathing dust, use only with adequate ventilation or in chemical fume hood, do not get in eyes or on skin, handle with proper protective equipment
Conditions for Safe Storage: Store sealed in original container at -20°C or as specified by supplier, protect from moisture, light, and heat, label clearly
Incompatible Materials: Strong oxidizers, acids, bases, and reducing agents
Special Requirements: Keep away from food, animal feed, and incompatible chemicals, keep container tightly closed when not in use
Exposure Limits: No established Occupational Exposure Limits; treat as hazardous chemical
Engineering Controls: Use chemical fume hood, ensure local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves, long-sleeved lab coat, safety goggles, N95 or similar respirator
Hygiene Measures: Wash hands before eating or using restroom, remove contaminated clothing promptly, do not eat, drink, or smoke where handled
Environmental Controls: Prevent environmental release through careful containment and waste disposal practices
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH (1% solution): 4.5 – 7.5
Melting Point: Decomposes above 180°C
Boiling Point: Not available (degrades before boiling)
Flash Point: Not applicable (non-volatile solid)
Solubility: Freely soluble in water, slightly soluble in alcohol
Partition Coefficient (n-octanol/water): Not available
Vapor Pressure: Not relevant
Density: Approximately 1.5 g/cm³ (calculated)
Viscosity: Not applicable
Other Properties: Stable under recommended storage conditions, light sensitive
Chemical Stability: Stable at recommended conditions in original container
Reactivity: No dangerous reactions under normal conditions
Conditions to Avoid: Exposure to moisture, strong heating, light
Incompatible Materials: Strong acids, bases, oxidizers, and reducing agents
Hazardous Decomposition: May produce toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides at decomposition temperatures
Polymerization: No known hazardous polymerization
Acute Toxicity: Oral LD50 (mouse) 500 mg/kg, inhalation LC50 not available
Skin Irritation: May cause mild to moderate skin irritation following contact
Eye Irritation: Can lead to redness, tearing, and discomfort
Sensitization: Prolonged or repeated exposure may cause allergic skin response
Chronic Effects: Reproductive and genetic effects seen in laboratory studies
Carcinogenicity: Not listed as carcinogen by OSHA, IARC, or NTP
Target Organs: Liver, kidneys if ingested repeatedly
Symptoms of Overexposure: Nausea, vomiting, fatigue, dermatitis, rare respiratory effects
Aquatic Toxicity: Harmful to aquatic life at significant concentrations
Persistence and Degradability: Antibiotic may persist in environment, limited biodegradation
Bioaccumulation: Potential for bioaccumulation exists, but not well studied
Mobility in Soil: Water soluble, could migrate in moist environments
Other Adverse Effects: May impact microbial activity in soil and water ecosystems, use with care to avoid environmental release
Disposal Methods: Place waste in tightly sealed, labeled containers, dispose according to local, regional, and national regulations
Waste Classification: Considered hazardous chemical waste
Recommended Disposal: Incineration or application to licensed hazardous waste facility
Contaminated Packaging: Wash or incinerate packaging based on local guidelines
Precautions: Do not allow contamination of water, food supplies, or natural habitats
UN Number: Not regulated for ground, air, or sea transport as a hazardous substance
Proper Shipping Name: Hygromycin B, not restricted
Transport Hazard Class: Not classified
Packing Group: Not applicable
Special Precautions: Ship in secure, sealed packaging to prevent accidental release, ensure compliance with shipping requirements for laboratory chemicals
Environmental Hazards: May be harmful to aquatic environments in case of spills
OSHA: Not specifically regulated, general chemical safety applies
TSCA Status: Listed
REACH Status: Not fully registered for all uses in Europe
SARA Title III: No reportable components
California Proposition 65: Not listed
WHMIS (Canada): D2A (very toxic material)
Other Standards: Handle in accordance with good laboratory practices and local chemical hygiene plans
