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Product Name: Hydroxyzine Hydrochloride
Chemical Formula: C21H27ClN2O2·HCl
Synonyms: Atarax, Hydroxyzinum Chloratum
CAS Number: 2192-20-3
Recommended Use: Pharmaceutical intermediate, Prescription Antihistamine
Supplier: Pharmaceutical manufacturers, chemical distributors
Emergency Contact: Poison control center, hospital emergency department
GHS Classification: Acute Toxicity (Oral) Category 4; Eye Irritation Category 2A
Label Elements: Exclamation mark, Health hazard pictogram
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Causes serious eye irritation
Precautionary Statements: Avoid breathing dust, Wash thoroughly after handling, Wear eye protection, Do not eat or drink near product
Other Hazards: May cause drowsiness or dizziness, Possible allergic reactions
Chemical Name: Hydroxyzine Hydrochloride
Concentration: >98% by weight
Impurities: Trace residual solvents and related substances from synthesis
Common Additives: None present in pure API form
Inhalation: Move person to fresh air immediately, keep comfortable for breathing; get medical advice if symptoms persist
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; seek medical attention for irritation
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if easy to do; seek medical advice
Ingestion: Rinse mouth; drink water if alert; do not induce vomiting; get prompt medical attention
Most important symptoms and effects: Drowsiness, impaired coordination, nausea, possible respiratory depression in severe cases
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: High-pressure water jet can spread powder
Special Hazards: Toxic fumes of hydrochloric acid, nitrogen oxides, and carbon oxides
Advice for Firefighters: Wear self-contained breathing apparatus, chemical protective clothing; avoid inhaling combustion products; fight fire from upwind location
Personal Precautions: Use personal protective equipment, avoid contact with skin, eyes, and clothing; prevent dust formation
Environmental Precautions: Prevent entry into drains, sewers, or natural water bodies
Containment and Cleanup Methods: Sweep up spilled material without generating dust; place in a suitable, sealed container for disposal; ventilate area; wash spill site after material pickup is complete
Safe Handling Guidelines: Handle in well-ventilated area; avoid dust formation; practice good hygiene; use appropriate PPE
Storage Requirements: Store tightly closed in cool, dry, well-ventilated area; keep away from incompatible substances such as strong oxidizers and acids; avoid exposure to excessive moisture and light
Special Storage Considerations: Use containers resistant to chemical corrosion; segregate from food, feed, and incompatible chemicals
Occupational Exposure Limits: No established OSHA PEL or ACGIH TLV for Hydroxyzine Hydrochloride
Engineering Controls: Use local exhaust ventilation, fume hoods, or process enclosures
Eye/Face Protection: Safety goggles or face shield
Skin Protection: Nitrile gloves, lab coat, protective sleeves
Respiratory Protection: Dust mask or NIOSH-approved respirator when airborne particulate is present
Hygiene Measures: Wash hands and exposed skin after handling; do not eat, drink, or smoke in work area
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
pH (aqueous solution): 4.0–4.5 (1% solution)
Melting Point: 190°C–194°C (dec.)
Solubility: Freely soluble in water; slightly soluble in ethanol
Partition Coefficient (log Pow): Not available
Vapor Pressure: Negligible at room temperature
Density: 1.3–1.5 g/cm³ (bulk)
Boiling Point: Decomposes before boiling
Evaporation Rate: Not applicable
Chemical Stability: Stable under normal conditions; sensitive to moisture and light
Possible Hazardous Reactions: No dangerous reactions expected under normal use
Conditions to Avoid: High humidity, elevated temperatures, direct sunlight
Incompatible Materials: Strong oxidizing agents, strong acids, alkalis
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide
Acute Toxicity: LD50 (oral-rat): approx. 123 mg/kg
Skin Corrosion/Irritation: May cause mild irritant effects
Serious Eye Damage/Irritation: Causes moderate to severe irritation
Respiratory or Skin Sensitization: Risk of allergic reactions on repeated exposure
Mutagenicity/Genotoxicity: No evidence reported in standard test systems
Reproductive toxicity: Not observed at therapeutic exposures, but limited data available
Other Information: Drowsiness, impaired alertness, possible ataxia, headache, dry mouth, occasional tachycardia
Ecotoxicity: May be harmful to aquatic organisms at high concentrations
Persistence and Degradability: Low biodegradation rate, potential for persistence in environment
Bioaccumulative Potential: Expected to have low bioaccumulation
Mobility in Soil: Expected to be moderately mobile, depending on soil type and pH
Other Adverse Effects: No known significant effects or critical hazards in intended pharmaceutical use; avoid uncontrolled release
Waste Treatment Methods: Collect and contain for landfill or incineration in accordance with local/regional/national/international regulations; do not discharge to environment
Special Precautions: Use gloves and respiratory protection during waste handling interventions; label and store waste in closed containers
Disposal of Contaminated Packaging: Wash with water and neutral detergent; dispose of as chemical waste
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Not classified as marine pollutant
Special Precautions for Transport: Avoid direct sunlight, moisture, and crushing during transit; store in original containers
Safety, Health, and Environmental Regulations: Complies with requirements under US OSHA Hazard Communication Standard, EU REACH Regulation; not listed as a controlled substance
TSCA Inventory: Not listed
EINECS/ELINCS Number: Listed
Other National Inventories: Included in appropriate pharmaceuticals lists; not regulated under most chemical safety conventions
Labeling Requirements: Pharmaceutical packages must bear proper caution, warning and safe-use instructions under applicable health regulations
