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Product Name: Hydroxypropyl Methylcellulose
Chemical Family: Cellulose ether
Synonyms: HPMC, Hypromellose
CAS Number: 9004-65-3
Recommended Use: Thickener, binder, film former in industries such as construction, pharmaceuticals, food, personal care, paint, and adhesives
Supplier: Refer to packaging or invoice documentation for manufacturer and distributor contact details, including address and emergency phone number
Classification: Not classified as hazardous according to GHS or OSHA Hazard Communication Standard
Physical Hazards: Dust can form explosive mixtures in air
Skin Contact: Prolonged exposure may cause mild dryness or irritation
Eye Contact: Dust may cause mechanical irritation
Inhalation: Inhalation of dust may cause coughing, sneezing, or mild respiratory irritation
Chronic Effects: No evidence of carcinogenic, mutagenic, or reproductive toxicity with normal use
Environmental Hazards: Not classified as hazardous to the environment, but release of large quantities should be avoided
Chemical Name: Hydroxypropyl Methylcellulose
Content: 98–100% by weight
Impurities: Trace levels of sodium chloride, methanol residues (typically below regulatory limits), and other process-based residuals
Molecular Formula: C12H20O10
Molecular Weight: Varies by product grade, typically 86,000 – 120,000 g/mol
General Advice: Move individual away from source of exposure and into fresh air
Eye Contact: Rinse cautiously with plenty of water for several minutes; seek medical attention for persistent irritation
Skin Contact: Wash affected area with soap and water; seek advice if irritation continues
Inhalation: Remove to fresh air; provide oxygen if breathing becomes difficult; seek care if symptoms persist
Ingestion: Rinse mouth with water; drink water to dilute; seek medical attention if discomfort develops
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide can be used
Specific Hazards: Fine dust dispersed in air and exposed to an ignition source may ignite or explode
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and possibly irritating hydrocarbons
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing
Special Precautions: Avoid dust formation during firefighting; control run-off, as contaminated water may cause environmental effects
Personal Precautions: Avoid dust formation; use protective mask, goggles, and gloves
Spill Cleanup: Prevent further leakage or spillage if safe; sweep or vacuum up material; collect in suitable, labeled containers for disposal
Environmental Precautions: Prevent entry into drains, groundwater, or surface water
Methods for Cleaning: Use non-sparking tools; ventilate area as necessary; wash area with water after cleanup
Handling: Avoid breathing dust; ensure adequate ventilation; wash hands thoroughly after handling; handle in a way to minimize dust generation; avoid creating airborne dust clouds
Technical Measures: Ground and bond containers and equipment to reduce static discharge risk
Storage Conditions: Store in dry, cool, well-ventilated location away from sources of ignition and incompatible materials; keep containers tightly closed
Incompatible Materials: Strong oxidizers, acids, and alkalis
Hygiene Suggestions: Do not eat, drink, or smoke while using this material
Occupational Exposure Limits: No established permissible exposure limits; ACGIH recommends observing nuisance dust limits: 10 mg/m3 (total dust), 3 mg/m3 (respirable fraction)
Engineering Controls: Use local exhaust ventilation or process enclosure to minimize dust exposure
Respiratory Protection: Use NIOSH-certified dust masks in poorly ventilated areas or if dust generation is likely
Eye Protection: Wear safety glasses with side shields
Hand Protection: Use disposable gloves or chemical-resistant gloves when prolonged contact is expected
Skin Protection: Wear protective clothing to avoid prolonged skin contact
General Controls: Provide eyewash facilities and emergency showers
Appearance: White or off-white fibrous or granular powder
Odor: Odorless or mild cellulose odor
pH (1% solution): 5.5–8.0
Melting Point/Freezing Point: No melting point; decomposes above 200°C
Boiling Point: Not applicable
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not flammable in bulk; dust may be combustible
Vapor Pressure: Not applicable
Bulk Density: 300–500 kg/m3 (varies by grade)
Solubility: Soluble in cold water, forms colloidal solution; insoluble in hot water, ethanol, or acetone
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not reactive under recommended conditions
Possible Hazardous Reactions: May form explosive dust–air mixtures
Conditions to Avoid: Excess moisture, sources of ignition, open flames, incompatible substances
Incompatible Materials: Strong oxidizing agents, acids, and bases
Hazardous Decomposition Products: Carbon oxides, aldehydes, and other hydrocarbon fragments upon combustion or thermal decomposition
Acute Toxicity: Oral LD50 (rat) > 5,000 mg/kg; not considered toxic by ingestion
Skin Corrosion/Irritation: Non-irritating to skin with normal use
Serious Eye Damage/Irritation: Mechanical irritation possible if dust gets in eyes
Sensitization: Not sensitizing to skin or respiratory tract
Germ Cell Mutagenicity: No evidence of mutagenic effects
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No reproductive toxicity found in animal studies
Specific Organ Toxicity: No effects reported on target organs
Aspiration Hazard: Not considered an aspiration risk
Ecotoxicity: Not expected to cause environmental harm at concentrations likely to be encountered
Aquatic Toxicity: No acute toxicity to aquatic organisms (fish, daphnia, algae) at relevant concentrations
Persistence and Degradability: Biodegradable; undergoes slow decomposition by natural processes
Bioaccumulative Potential: Low potential for bioaccumulation; large, water-soluble molecule
Mobility in Soil: Moderately mobile in soil when dissolved; does not penetrate deep groundwater
Other Adverse Effects: May cause physical effects such as reduced oxygen levels in water if present in massive amounts
Disposal Methods: Dispose of in accordance with local, regional, and national regulations; landfill or incineration may be suitable
Waste from Residues: Collect and place in suitable containers; avoid generating dust during disposal
Contaminated Packaging: Empty containers may be recycled or disposed of; ensure they are thoroughly cleaned before reuse
Do Not: Discharge into drains, surface, or groundwater unless in accordance with regulatory permits
UN Number: Not regulated for transport by land, sea, or air
UN Proper Shipping Name: Not classified as a hazardous material
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions for User: Protect shipments from moisture and strong oxidizing agents
Transport Labels: No hazard label required
United States (OSHA): Not a hazardous substance or mixture under OSHA 29 CFR 1910.1200
TSCA Inventory: Listed
SARA Title III: Not subject to reporting under Sections 302, 304, or 313
EU Regulations: Not classified as a dangerous substance under ECHA/REACH, CLP, or DSD/DPD
Canada: DSL/NDSL – Listed
Australia: AICS – Listed
Labeling: Not required, substance is not classified as hazardous
Other Requirements: Comply with food, pharmaceutical, or environmental regulations as applicable according to end use
