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Product Name: Hydroxyprogesterone Acetate
Synonyms: 17α-Hydroxy-6α-methylprogesterone acetate
Chemical Formula: C24H34O4
Molecular Weight: 386.52 g/mol
CAS Number: 302-23-8
Recommended Use: Active pharmaceutical ingredient, hormone therapy
Supplier Information: Manufacturer or distributor details listed on packaging, with emergency contact phone numbers accessible at all times.
Hazard Class: Reproductive toxicity, possible endocrine disruption
Signal Word: Warning
Hazard Statements: May harm unborn children; suspected of damaging fertility; may cause skin and eye irritation; inhalation may cause respiratory tract irritation and headache
Pictograms: Health hazard symbol, exclamation mark
Precautionary Statements: Wash hands after handling; avoid inhaling dust or vapors; use personal protective equipment; avoid breathing dust; avoid release to the environment.
Chemical Name: Hydroxyprogesterone Acetate
Percentage: Up to 100% (pure material for laboratory or industrial use)
Impurities: Trace amounts of related steroids, batch-dependent process residues (full analytical specs available upon request).
Inhalation: Remove exposed person to fresh air, seek immediate medical care if symptoms persist — dizziness, difficulty breathing, headache
Skin Contact: Remove contaminated clothing, rinse skin with copious amounts of soap and water, consult medical advice for allergic reactions or irritation
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, and obtain medical attention for persistent discomfort
Ingestion: Rinse mouth, avoid inducing vomiting, seek medical attention without delay — hormonal effects may arise after accidental swallowing
Most Important Symptoms: Irritation, reproductive effects, nausea; medical observation recommended longer term after high exposure.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, incompletely oxidized steroid fragments
Protective Equipment: Self-contained breathing apparatus, full protective suit
Specific Hazards: Dust may form explosive mixture with air in enclosed spaces — regular review of risk in production and storage
Fire Fighting Instructions: Cool exposed containers with water spray, avoid inhaling fumes or direct contact with runoff.
Personal Precautions: Ventilate the area, wear gloves, goggles, lab coat, and a particulate respirator as needed
Environmental Precautions: Avoid allowing product to enter drains, open water, or soil
Clean-Up: Sweep up spill gently to minimize dusting, place in suitable, leak-proof, labeled containers for disposal — clean area with damp cloth, avoid dry sweeping for powder, use only tools rated for hazardous pharmaceutical clean-up.
Handling: Work with the substance in a chemical fume hood or controlled area; wear PPE, wash hands and forearms thoroughly after handling, prevent generation of dust, keep containers tightly sealed between uses
Storage: Store in cool, dry, well-ventilated location, away from incompatible materials; temperature controls required for bulk lots to maintain material integrity; segregate from oxidizers and acids.
Engineering Controls: Laboratory fume hood or local exhaust ventilation at use points prevents airborne exposure
Personal Protective Equipment: Chemical-resistant gloves (nitrile), impervious lab coat, safety eyewear or face shield, approved dust respirator with P100 filter
Hygiene Measures: Strict no food, drink, or smoking near handling areas; change out of work clothing after shift; eye wash stations and safety showers located in immediate area.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint steroid-like odor
Melting Point: Approximately 205–215 °C
Solubility: Insoluble in water, soluble in ethanol, chloroform, most organic solvents
pH: Not applicable (non-aqueous solid)
Partition Coefficient (log Kow): Estimated at 3.5–4.5 (highly lipophilic)
Vapor Pressure: Negligible at room temperature
Density: Around 1.15–1.25 g/cm³
Other Properties: Decomposes on strong heating, forms fines when ground.
Chemical Stability: Stable under normal laboratory conditions, sensitive to strong light and heat
Incompatible Materials: Strong oxidizers, concentrated acids, alkalis
Hazardous Decomposition: Produces carbon monoxide, carbon dioxide, toxic steroid fragments under fire conditions
Polymerization: Does not polymerize, but dust explosions possible with fine powders in confined environments.
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: May cause mild skin or mucous membrane irritation, headache, nausea
Chronic Effects: Reproductive hormone disruption, menstrual changes, teratogenicity, endocrine disturbances
Carcinogenicity: No adequate data for classification; avoid unnecessary exposure due to hormone activity
Sensitization: Uncommon, but repeated skin exposure may cause contact dermatitis
Other Effects: Symptoms can appear delayed and persist after exposure.
Ecotoxicity: Synthetic hormone — potential to disrupt aquatic organisms’ endocrine systems
Persistence and Degradability: Degrades slowly in the environment, risk for persistence in soil and water
Bioaccumulative Potential: Moderate to high, given steroid structure
Mobility in Soil: Low to moderate, adheres to organic matter
Water Pollution: Releases into waste streams may require monitoring and secondary treatment to prevent harm.
Waste Treatment Methods: Incinerate in approved chemical waste facility, following local, regional, and national regulations for pharmaceutical disposal
Contaminated Packaging: Dispose of as hazardous waste, decontaminate if possible
Precautions: Avoid discharges to environment; do not flush to drain or sewer; keep waste segregated and secure until proper disposal.
UN Number: Not regulated under most international transport conventions — confirm with latest ADR, IATA, IMDG listings
Transport Hazard Class: Not classified as hazardous for transport by IMO, ICAO, or US DOT; check local exceptions
Packaging Requirements: Leak-proof, tamper-evident containers, labeled according to lab and pharmacy requirements
Special Precautions: Secure containers during transit; transport documentation to include emergency contact and handling instructions.
Safety, Health, Environmental Regulations: Subject to workplace health rules for potent pharmaceuticals and synthetic hormones
OSHA: No PEL established; handle as a hazardous drug under NIOSH guidelines
TSCA: Not listed as a general-use chemical
EU Regulations: Classified under REACH and CLP; requirements for risk assessment and exposure controls
Other: Specific licensing or compounding regulations apply to workplace handling and environmental management; all website and label information must align with national disclosure standards and safe use policy for pharmaceuticals.
