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Product Name: Hydroxyethyl Urea
Chemical Formula: C3H8N2O2
CAS Number: 2078-71-9
SYNONYMS: 2-Hydroxyethylurea, Ethanolurea
Recommended Use: Cosmetic ingredient, humectant in personal care products
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GHS Classification: Not classified as hazardous under GHS criteria
Signal Word: None
Pictograms: None required
Hazard Statements: Not expected to be harmful in normal use, dust or mist may cause mild irritation to eyes and respiratory tract
Precautionary Statements: Avoid excessive inhalation, avoid prolonged skin contact, keep out of reach of children
Other Hazards: Not a combustible dust, not bioaccumulative, not known to produce acute or chronic health hazards in intended applications
Chemical Name: Hydroxyethyl Urea
Concentration: ≥98%
Other Components: Water (<2%), possible trace stabilizers not considered hazardous
Impurities: None expected to contribute to classification
Excipients: Not applicable
Eye Contact: Rinse cautiously with plenty of water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation persists.
Skin Contact: Wash with plenty of soap and water. Seek medical attention for persistent redness or other symptoms.
Inhalation: Move person to fresh air. Seek medical attention if symptoms such as cough or shortness of breath continue.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Seek medical attention if feeling unwell.
Most Important Symptoms / Effects: Mild eye or respiratory irritation possible. Not expected to cause sensitization.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, or foam
Unsuitable Extinguishing Media: Strong water jet
Specific Hazards from Combustion: Carbon oxides, nitrogen oxides, and possibly ammonia fumes could form in fire
Protective Equipment for Firefighters: Firefighters should wear full protective gear and self-contained breathing apparatus
Advice for Firefighters: Cool containers with water spray if exposed to fire. Use water fog to control vapors.
Personal Precautions: Avoid breathing dust. Wear suitable protective clothing, gloves, and eye protection.
Environmental Precautions: Prevent product from entering drains, watercourses, and soil.
Methods for Containment and Clean-Up: Sweep up spilled material and place in labeled containers for disposal. Wash spill area with water. Use non-sparking tools.
Additional Advice: Dispose of material in accordance with local regulations. Avoid creating dust.
Precautions for Safe Handling: Avoid contact with eyes, skin, and clothing. Use personal protective equipment. Keep containers tightly closed. Avoid breathing dust.
Conditions for Safe Storage: Store in a cool, dry place away from sunlight and incompatible materials. Keep container sealed. Avoid temperature extremes.
Incompatible Materials: Strong oxidizing agents, acids
Other Advice: Practice good industrial hygiene. Do not reuse containers unless properly cleaned.
Occupational Exposure Limits: Not established for this material
Engineering Controls: Use local exhaust ventilation or process enclosure to reduce dust generation and airborne levels.
Personal Protective Equipment:
Eye: Safety glasses or goggles
Skin: Impervious gloves
Respiratory: NIOSH-approved dust mask if dust anticipated
Body: Protective work clothing
Hygiene Measures: Wash hands thoroughly after use. Do not eat, drink, or smoke when using this product.
Appearance: White to off-white crystalline powder
Odor: Characteristic, faint
Melting Point: 129–133°C
Boiling Point: Decomposes before boiling
pH: 6.5–7.5 (10% aqueous solution)
Solubility: Completely soluble in water
Partition Coefficient (Log Kow): -2.11 (estimated)
Vapor Density: Not available
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable
Auto-ignition Temperature: Not determined
Decomposition Temperature: >150°C
Evaporation Rate: Not applicable
Viscosity: Not applicable (solid)
Chemical Stability: Stable under normal use and storage conditions
Hazardous Reactions: Will not occur with proper handling
Materials to Avoid: Strong oxidizers, strong acids
Decomposition Products: Carbon oxides, nitrogen oxides, ammonia when heated to decomposition
Conditions to Avoid: Exposure to excessive heat, moisture, incompatible substances
Acute Toxicity: Low oral and dermal toxicity. Oral LD50 (rat) > 2000 mg/kg
Skin Corrosion/Irritation: Non-irritating in standard tests
Eye Damage/Irritation: Mild irritation possible
Respiratory Sensitization: Not sensitizing
Skin Sensitization: Not sensitizing
Mutagenicity: Not mutagenic in available studies
Carcinogenicity: No evidence based on animal studies
Reproductive Toxicity: Not expected based on structure and data
Other Effects: Not anticipated to accumulate in organs; no chronic health effects known at typical exposure levels
Ecotoxicity: Not expected to be hazardous to aquatic life. EC50 (Daphnia magna, 48hr) >100 mg/L
Persistence and Degradability: Readily biodegradable in water and soil based on structure and analogous compounds
Bioaccumulative Potential: Bioaccumulation unlikely, log Kow -2.11
Mobility in Soil: High mobility due to excellent water solubility
Other Adverse Effects: No known significant environmental hazards reported
Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations.
Container Disposal: Containers and residues should be managed as chemical waste. Do not reuse empty containers before proper cleaning.
Avoid Release: Prevent runoff into surface waters, sewer systems
Special Instructions: Incineration or landfill in permitted facility may be required, confirm with local authorities for preferred option.
UN Number: Not regulated for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: No
Special Precautions: Protect containers from breakage and handle with standard care for chemical powders. Comply with local rules.
TSCA Status: Listed
EU REACH Status: Registered or exempt
California Prop 65: Not listed
OSHA Hazard Communication: Not classified as hazardous
Canada DSL/NDSL: Listed
WHMIS Classification: Not controlled
Other Regulations: No specific U.S. FDA restrictions for use in cosmetics at typical concentrations
Restrictions: None known in current markets, verify local regulations before large-scale use or disposal
