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Product Name: Hydroxychloroquine Sulfate
Synonyms: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Chemical Formula: C18H26ClN3O·H2SO4
CAS Number: 747-36-4
Manufacturer: Pharmaceutiсal producers or distributors
Use: Treatment of malaria, certain autoimmune disorders such as lupus and rheumatoid arthritis
Classification: Acute toxicity (oral, inhalation, dermal), Eye irritation, Skin sensitization
Label Elements: Signal word: Danger; Hazard statements: Toxic if swallowed, causes serious eye irritation, may damage organs through prolonged or repeated exposure
Symptoms: Headache, dizziness, nausea, vomiting, visual disturbances, cardiac arrhythmia, respiratory distress
Health Hazards: Kidney and liver injury, heart rhythm problems, potential for irreversible vision damage
Environmental Hazards: Toxic to aquatic organisms, persistence in certain water sources
Main Ingredient: Hydroxychloroquine Sulfate
Concentration: Typically 100% (pharmaceutical grade); non-pharmaceutical forms may contain minor impurities
Impurities: Related alkaloids, trace elements from synthesis, sulfate counterion
Inactive Ingredients: Tablet forms may include lactose, starch, magnesium stearate, povidone, talc
Structure: Synthetic organic compound with a quinoline core and substituted side chains
Ingestion: Seek immediate medical attention; do not induce vomiting unless directed by medical personnel; monitor for respiratory distress or loss of consciousness
Inhalation: Move affected person to fresh air; seek medical advice in case of prolonged symptoms
Skin Contact: Remove contaminated clothing; wash skin thoroughly with mild soap and water; seek assistance if irritation persists
Eye Contact: Rinse cautiously with clean water for at least fifteen minutes; remove contact lenses if present and easy to do; seek medical attention
Notes for Physicians: Symptomatic and supportive treatment is vital; monitor cardiac and renal function, consider administration of activated charcoal in recent ingestion
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam; avoid water jet
Special Hazards: Decomposition can release irritating or toxic fumes of nitrogen oxides, sulfur oxides, hydrogen chloride
Protective Equipment: Fire fighters should wear self-contained breathing apparatus and full protective gear
Precautions: Stay upwind to avoid smoke; move containers from fire area if possible without risk; avoid breathing combustion products
Personal Precautions: Wear suitable protective clothing, gloves, and eye/face protection; make sure to avoid ingestion, inhalation, or skin contact during clean-up
Environmental Precautions: Prevent uncontrolled discharge into waterways, drains, or soil
Methods for Containment: Sweep up without generating dust, place in suitable waste container; ventilate affected area
Cleanup Procedure: Wash spill site after material pickup is complete; avoid creating airborne dust; dispose following local regulations
Handling: Avoid contact with skin, eyes, and clothing; ensure proper ventilation in storage and use areas; practice good hygiene by washing hands thoroughly after handling
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated location; keep away from sources of heat, direct sunlight, incompatible substances (strong oxidizers, acids)
Special Instructions: Secure storage area to prevent unauthorized access; keep away from food and beverages
Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels below recommended limits
Personal Protective Equipment: Use chemical-resistant gloves (nitrile preferred), goggles or face shield, lab coat or suitable coveralls; in the event of significant exposure risk, use respiratory protection
Hygiene Measures: Wash thoroughly after handling, before eating, drinking, or smoking; remove contaminated clothing and launder before reuse
Exposure Limits: No established OSHA or ACGIH exposure limits for hydroxychloroquine sulfate; minimize exposure as a general precaution
Form: White to off-white crystalline powder or granules
Odor: Virtually odorless
Solubility: Freely soluble in water, slightly soluble in alcohol
pH (1% solution): Around 3.5 to 4.5
Melting Point: Decomposes above 190°C
Boiling Point: Not available
Vapor Pressure: Not volatile at room temperature
Molecular Weight: 433.95 g/mol
Other Data: Stable under standard storage conditions, sensitive to light and moisture
Chemical Stability: Stable under recommended storage conditions; degrades in direct sunlight or upon prolonged exposure to heat
Reactivity: Non-reactive under normal and anticipated conditions of use and storage
Incompatible Materials: Strong acids, strong oxidizing agents, strong bases
Hazardous Decomposition Products: May emit hazardous fumes of nitrogen oxides, sulfur oxides, hydrogen chloride, and carbon oxides if heated to decomposition
Polymerization: No hazardous polymerization expected under normal conditions
Acute Toxicity: LD50 (oral, rat): 1240 mg/kg; higher sensitivity reported in children and some adults
Routes of Exposure: Oral most common, but risks include dermal and inhalation with powder forms
Symptoms of Exposure: Nausea, vomiting, abdominal pain, confusion, visual disturbances, convulsions, cardiac arrhythmias, severe hypotension
Chronic Effects: Possible irreversible eye damage (retinal toxicity), rare heart failure with long-term use, nervous system and neuromuscular effects
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Mutagenicity: No significant genotoxicity reported in mammalian systems
Reproductive Toxicity: Use during pregnancy only if benefit justifies risk; potential for adverse effects on fetus in animal studies
Target Organs: Eyes, heart, liver, blood
Ecotoxicity: Toxic to aquatic life, especially organisms sensitive to quinoline derivatives; risk for bioaccumulation in sediments or waterways
Persistence and Degradability: Low rate of biodegradation; stable in the environment for extended periods
Mobility in Soil: Limited mobility in soils due to affinity for organic matter
Other Adverse Effects: Limited data point to acute risk for fish and invertebrates; long-term effects unknown for some species
Safe Disposal: Place unused product, contaminated materials, and waste in properly labeled hazardous waste containers; incinerate or landfill as allowed by local, state, or federal environmental regulations
Waste Codes: Follow pharmaceutical hazardous waste designation codes per local authorities
Precautions: Do not discharge into natural waterways, storm sewer systems, or open ground
Recycling/Recovery: Not suitable for recycling or recovery; avoid attempts to neutralize except by licensed facilities
UN Number: Not regulated for ground transport in many jurisdictions; check air or maritime regulations due to toxicity
Proper Shipping Name: Hydroxychloroquine Sulfate, pharmaceutical preparation
Transport Hazards: Avoid packaging that might crack or rupture; prevent exposure to moisture or heat during transit
Packing Group: Not assigned by most authorities; consult responsible transport body
Special Provisions: Ensure containers remain upright and undamaged; mark with relevant safety identifiers
US Regulation: Listed as a prescription pharmaceutical; subject to FDA controls; not regulated as a controlled substance
EU Classification: Hazard statements for toxicity, eye irritation, environmental risk; labeled according to Regulation (EC) No 1272/2008
Workplace Limits: No specific ACGIH TLV or OSHA PEL; voluntary adherence to best practice limits
Other Guidelines: Waste disposal and spill response governed by EPA RCRA criteria or local equivalents; product registration and sale limited to regulated healthcare and pharmaceutical distribution channels
SDS Requirement: Must provide hazard communication and access to workers under OSHA Hazard Communication Standard
