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Product Name: Hydroxocobalamin Hydrochloride
Chemical Formula: C62H90CoN13O15P•HCl
CAS Number: 13422-51-0
Molecular Weight: 1384.38 g/mol
Intended Use: Pharmaceutical raw material, vitamin B12 supplementation, research applications
Manufacturer: Refer to label or supplier for specific contact information
Emergency Contact Number: Refer to local guidelines for poison control and chemical emergency services
GHS Classification: Not classified as hazardous according to GHS criteria
Hazard Statements: May cause mild eye, skin, or respiratory irritation in sensitive individuals
Signal Word: None required
Pictograms: None required under normal use conditions
Health Hazards: Inhalation can cause irritation to respiratory tract, large ingestion quantities may cause nausea
Environmental Hazards: Low potential for aquatic toxicity under normal handling
Physical Hazards: Non-flammable, not reactive under typical storage or use environments
Chemical: Hydroxocobalamin Hydrochloride
Concentration: ≥ 98% pure
Impurities: Trace related analogues within compendial limits
Synonyms: Hydroxycobalamin HCl, Vitamin B12a hydrochloride
Ingredient Category: Single active compound
Inhalation: Move person to fresh air, seek medical attention if symptoms persist or respiratory discomfort occurs
Skin Contact: Remove contaminated clothing, wash affected skin with water and soap
Eye Contact: Rinse eyes cautiously with plenty of water for at least fifteen minutes, remove contact lenses if present, continue rinsing, seek attention if irritation develops
Ingestion: Rinse mouth, offer small amounts of water, seek medical advice if large quantities are swallowed or discomfort appears
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, or foam
Specific Hazards: Product does not burn easily, may produce hazardous decomposition fumes including carbon monoxide, nitrogen oxides, hydrogen chloride
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Precautions: Avoid inhalation of smoke, evacuate personnel from area if fire extends to storage
Personal Precautions: Use appropriate personal protective equipment including gloves, goggles, and dust mask; ventilate area
Environmental Precautions: Prevent release into waterways, drains, or soil; report sizable spills to local authorities
Cleanup Methods: Absorb spill with inert material such as paper towel or cloth, collect into a suitable, labeled waste container for disposal, clean surfaces with soap and water
Handling: Work in well-ventilated area, avoid inhaling dust, avoid contact with eyes, skin, and clothing, do not eat, drink, or smoke when handling product
Storage Conditions: Store at room temperature (15-25°C), tightly closed container, protect from moisture and light, keep away from incompatible substances (strong oxidizers)
Safe Transfer: Use tools or equipment to transfer chemical, wear appropriate PPE during handling
Exposure Limits: No occupational exposure limits established by OSHA or ACGIH
Engineering Controls: Use local exhaust ventilation or process enclosure if dust generation is expected
Personal Protective Equipment: Nitrile or latex gloves, safety goggles, laboratory coat, approved dust mask
Hygiene Measures: Wash hands thoroughly after handling, do not touch face, remove contaminated clothing and wash before reuse
Appearance: Dark red to crimson crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (1% solution): 4.5 - 7.0
Melting Point/Range: Decomposes before melting above 200°C
Boiling Point: Not established
Solubility: Freely soluble in water, practically insoluble in ethanol and most organic solvents
Vapor Pressure: Not applicable (solid at RT)
Relative Density: Approximately 1.5 g/cm³
Partition Coefficient (n-octanol/water): No data
Other Data: Stable color under dry conditions, sensitive to prolonged light exposure
Chemical Stability: Stable under normal documented conditions of handling and storage
Conditions to Avoid: Avoid direct sunlight, excessive heat, high humidity
Incompatible Materials: Strong oxidizing agents, reducing agents, acids, bases
Hazardous Decomposition Products: May include CO, CO2, nitrogen oxides, phosphorus oxides, hydrogen chloride upon combustion or significant decomposition
Reactivity: No known hazardous reactions under regular use
Routes of Exposure: Inhalation, ingestion, eye and skin contact
Acute Toxicity: Unlikely to cause acute effects at low doses, oral LD50 (rat): not precisely determined, estimated low toxicity
Chronic Effects: No long-term studies indicating specific chronic toxicity
Potential Health Effects: High doses may cause mild gastrointestinal distress,
Irritation: Minor irritation possible on contact with eyes or mucous membranes
Sensitization: No data indicating potential for skin or respiratory sensitization
Carcinogenicity/Mutagenicity/Reproductive Toxicity: No indications in current studies
Aquatic Toxicity: No evidence of significant toxicity to aquatic organisms at environmental concentrations
Persistence and Degradability: Likely biodegradable based on chemical structure and known metabolic fate
Bioaccumulation: Not expected to bioaccumulate
Mobility in Soil: Water soluble, possible migration in groundwater if released
Environmental Fate: Expected to degrade under typical environmental conditions
Other Adverse Effects: None known from available data
Waste Disposal: Dispose of content and container in accordance with local, regional, national, and international regulations
Treatment: Incineration or landfill in compliance with regulatory requirements, avoid release to environment
Contaminated Packaging: Dispose as hazardous waste, ensure containers are empty before recycling or disposal
UN Number: Not classified as dangerous good for transport
Transport Hazard Class: Non-hazardous as per IATA, ADR, IMDG, US DOT
Packing Group: No special requirements
Special Precautions: Handle packages carefully to prevent breaking, avoid release of dust during transport
Labeling: No specific hazard symbols required on packaging
U.S. Regulations: Not regulated as hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200), not listed by SARA, CERCLA, or TSCA
EU Regulations: Not classified as hazardous under Regulation (EC) No 1272/2008 (CLP), no REACH restrictions
International Inventories: Present on inventories in major markets (e.g., EINECS, DSL)
Special Provisions: Avoid unnecessary exposure, maintain documentation for workplace safety practices
Labeling Requirements: Ensure complete and accurate hazard communication, safety instructions, and first aid information appear on containers
