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Product Name: Hydroxocobalamin Acetate
Synonyms: Vitamin B12a Acetate, Cyanocobalamin derivative
Chemical Formula: C62H89CoN13O15·CH3COOH
CAS Number: 22465-48-1
Recommended Use: Pharmaceutical manufacturing, laboratory chemical, research reagent
Manufacturer: [Manufacturer information]
Contact Details: [Address, emergency telephone number, email for safety information]
Classification: Not classified as hazardous according to GHS criteria
Possible Health Hazards: Inhalation may cause mild respiratory discomfort. Skin and eye contact could cause irritation in sensitive individuals. Ingestion in small quantities is unlikely to cause harm, but large doses can impact health.
Signal Word: None required
Hazard Statements: May cause irritation to skin, eyes, and respiratory tract. Not considered flammable or explosive.
Precautionary Statements: Use personal protective gear, avoid creating dust, wash thoroughly after handling, seek fresh air if inhaled by mistake.
Pictograms: None required under current regulations.
Chemical Name: Hydroxocobalamin Acetate
Synonyms: Hydroxyvitamin B12 Acetate
CAS Registry Number: 22465-48-1
PURITY: >98%
Component: Hydroxocobalamin cation, acetate anion, trace moisture
Impurities: Potential trace metals (Co++) at levels below 0.1%, negligible organics from synthesis
General: If exposure occurs, move away from contamination source.
Inhalation: Move the affected person to fresh air, rest in a semi-upright posture. Seek medical attention if breathing becomes difficult.
Skin Contact: Flush skin thoroughly with plenty of water and mild soap, remove any contaminated clothing.
Eye Contact: Rinse eyes with low-pressure clean water for several minutes, holding eyelids open.
Ingestion: Rinse mouth with water, avoid inducing vomiting. Get immediate medical attention if symptoms occur.
Special Notes to Physician: Treat symptomatically, no known antidote for overdosing.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or appropriate foam.
Hazardous Combustion Products: Cobalt oxides, nitrogen oxides, carbon oxides may form under fire conditions.
Protective Equipment: Firefighters should use full protective clothing and certified breathing apparatus.
Other Instructions: Cool exposed containers with water spray, prevent water runoff entering drains where possible.
Personal Precautions: Avoid dust formation, use mask, gloves, eye protection.
Environmental Precautions: Prevent entry into drains and surface water systems.
Clean-up Methods: Collect spilled powder using a HEPA vacuum or wet methods. Place material in sealable containers for disposal. Wash area thoroughly.
Decontamination: Rinse trace residues with copious water, ventilate area if needed.
Handling: Use in well-ventilated areas. Avoid breathing dust or vapor. Wear appropriate personal protection.
Storage: Store in tightly closed container in a cool, dry, ventilated place. Protect from light.
Incompatibilities: Strong oxidizing agents, extreme heat, sunlight exposure
Special Rules: No smoking, eating, or drinking in storage or use areas.
Engineering Controls: Use fume hood, laboratory exhaust ventilation.
Personal Protective Equipment: Chemical splash goggles, laboratory coat, nitrile gloves, dust mask or respirator (if needed).
Hygiene Measures: Wash hands and face after handling, remove contaminated clothes immediately.
Occupational Exposure Limit: No exposure limit established by OSHA, NIOSH or ACGIH for this compound.
Appearance: Dark red crystalline or powder solid
Odor: Odorless
Odor Threshold: Not determined
pH: Neutral to weakly acidic in water
Melting Point: Decomposes before melting (approx. 225°C)
Boiling Point: Not applicable (decomposes)
Flash Point: Not flammable
Evaporation Rate: Not volatile
Solubility: Soluble in water, slightly soluble in alcohol
Partition Coefficient (n-octanol/water): Not available
Vapor Pressure: Negligible
Relative Density: Approx. 1.5 g/cm³
Auto-ignition Temperature: Not determined
Decomposition Temperature: >200°C, forms toxic fumes
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions.
Reactivity: Inert to most common substances at room temperature.
Conditions to Avoid: Exposure to light, elevated temperatures, moisture, and incompatible materials.
Incompatible Materials: Strong oxidizers, acids, alkalis, reducing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, cobalt oxides.
Acute Toxicity: Very low toxicity by oral, dermal, or inhalation routes based on animal data for cobalamin compounds.
Irritation: Mild irritant to eyes and skin.
Chronic Exposure: No long-term health data specific to this salt, but cobalamin analogues show low risk.
Sensitization: Not reported for this substance.
Carcinogenicity: Hydroxocobalamin Acetate is not classified as carcinogenic by IARC, NTP, or OSHA.
Mutagenicity: No data indicating mutagenic effects under recommended use.
Reproductive Toxicity: No animal or human data showing reproductive risks.
Symptoms of Overexposure: Rare allergic reactions, headache, dizziness, skin redness in sensitive individuals.
Environmental Fate: Expected to degrade in environment, but no detailed data available.
Aquatic Toxicity: No known toxic effects on aquatic organisms at expected concentrations.
Bioaccumulation Potential: Not likely to accumulate, water-soluble.
Soil Mobility: Mobile and soluble in water.
Degradability: Breaks down under natural conditions.
Other Adverse Effects: No evidence for significant environmental hazard.
Waste Disposal Methods: Dispose in accordance with local, state, and federal regulations. Avoid release to environment.
Recommended Disposal: Incinerate or send to licensed chemical waste treatment facility.
Empty Containers: Triple rinse, then offer for recycling or disposal as hazardous waste.
Precautions: Do not mix with general or food waste. Prevent contamination of water sources.
UN Number: Not regulated for ground, air, or sea transportation
UN Proper Shipping Name: Non-hazardous chemical
Transport Hazard Class: Not classified
Packing Group: None
Special Precautions for User: Keep container tightly closed and protected from physical damage. Store in original packaging when transporting.
OSHA: Not listed as hazardous
TSCA: Listed
REACH: Not specifically registered, but falls under exemption as research chemical
SARA Title III: Not subject to reporting
California Proposition 65: Not listed as carcinogen/reproductive toxicant
Other: All ingredients appear on international inventories (EINECS, DSL, ENCS, AICS etc.)
Label Requirements: No mandatory signal words or pictograms required.
