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Product Name: Hydrocortisone Sodium Succinate
Synonyms: Hydrocortisone-21-hemisuccinate sodium salt, Solu-Cortef, Cortisol Sodium Succinate
CAS Number: 125-04-2
Usage: Pharmaceutical corticosteroid, anti-inflammatory agent
Manufacturer Contact: Provided by supplier or package insert
Emergency Numbers: Relevant poison control centers, local emergency responders
Recommended Use: Prescribed in hospitals and clinics to treat inflammation, allergies, and adrenal insufficiency
Classification: Not classified as hazardous under GHS for supplied form; may cause adverse health effects on prolonged exposure
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Irritation to eyes, skin, and respiratory tract possible after direct contact
Chronic Effects: Overexposure may contribute to adrenal suppression, Cushing’s syndrome, skin thinning, or immune suppression if mishandled
Target Organs: Adrenal glands, skin, immune system
Hazard Symbols: No specific pictogram under GHS, handle as potentially hazardous pharmaceutical under local guidelines
Signal Word: Caution
Chemical Name: Hydrocortisone sodium succinate
CAS Number: 125-04-2
EC Number: 204-729-7
Formula: C25H32O8Na
Purity: Pharmaceutical grade, typically exceeding 98%
Impurities: Minor quantities of residual succinic acid and sodium hydroxide (trace), water for injection as diluent in some presentations
Physical Form: White to off-white powder or crystalline solid, may be supplied sterile in vials for reconstitution
Inhalation: Move individual to fresh air immediately; monitor breathing; seek medical advice if symptoms develop
Skin Contact: Remove contaminated clothing and wash affected area thoroughly with soap and water; seek medical support if irritation continues
Eye Contact: Rinse eyes gently with plenty of water, lifting upper and lower lids occasionally; medical attention if symptoms do not resolve
Ingestion: Rinse mouth with water; do not induce vomiting unless instructed by a medical professional; seek advice from a poison center or physician promptly
Note to Physicians: Treat symptomatically; in cases of high accidental exposure, monitor adrenal function
Suitable Extinguishing Media: Use water spray, foam, carbon dioxide, or dry powder
Unsuitable Extinguishing Media: Avoid direct water jet onto material to prevent contamination spread
Specific Hazards: Combustion may generate carbon oxides and sodium oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing to prevent exposure to decomposition products
Special Procedures: Prevent runoff from entering drains or waterways; contain fire water if possible
Personal Protection: Use disposable gloves, protective gown, eye protection, and a dust mask or respirator
Spill Cleanup: Avoid generating dust; sweep or scoop up and place in appropriate containers for disposal; wipe down area with damp cloth
Ventilation: Ensure adequate mechanical ventilation in area of spill to prevent inhalation
Environmental Precautions: Prevent material from reaching sewers, surface, or groundwater
Decontamination: Clean surfaces thoroughly using soap and water; dispose of contaminated materials according to local regulations
Handling: Minimize dust generation and use in well-ventilated areas; avoid prolonged or repeated contact; wear proper protective equipment at all times; avoid any unnecessary exposure
Storage Conditions: Store in tightly closed containers; maintain under cool, dry, well-ventilated conditions; keep away from incompatible materials such as strong oxidizers; maintain at temperatures recommended by manufacturer—often 15–30°C
Special Precautions: Protect from light, moisture, and excessive heat; restrict access to trained personnel
Engineering Controls: Use local exhaust ventilation or fume hoods to minimize airborne concentrations
Exposure Limits: No occupational exposure limits set for hydrocortisone sodium succinate; general pharmaceutical handling guidelines apply
Personal Protection: Chemical-resistant gloves, protective eyewear, lab coats or gowns; in dusty conditions, NIOSH-approved respirators
Hygiene Measures: Wash hands and exposed skin thoroughly before eating, drinking, or leaving work area
Environmental Controls: Implement procedures to prevent contamination of drains, watercourses, or soil during use and disposal
Appearance: White to off-white, crystalline powder
Odor: Odorless or faint medicinal smell
Molecular Weight: 484.51 g/mol
Solubility: Freely soluble in water
Melting Point: Around 217°C (decomposes)
pH: Reconstituted solution usually in the range 7.0–8.0
Boiling Point: Not applicable; decomposes before boiling
Vapor Pressure: Not volatile
Flash Point: Not flammable under normal conditions
Chemical Stability: Stable under recommended storage conditions in original, sealed packaging
Conditions to Avoid: Excessive heat, humidity, direct sunlight; avoid contact with strong acids or bases
Incompatibilities: Strong oxidizing agents may react with product
Decomposition Products: Fumes of carbon oxides, sodium oxides may evolve at high temperatures
Hazardous Reactions: No dangerous reactions expected under normal handling and storage conditions
Acute Toxicity: Low acute toxicity based on animal studies; direct exposure could cause local irritation
Chronic Toxicity: Prolonged or repeated contact or misuse may suppress immune and adrenal function, impact metabolism, or cause Cushingoid features
Potential Health Effects: Risk of allergic skin reactions, eye redness, shortness of breath after inhalation of large quantities of dust; immunosuppression with high exposure
Routes of Exposure: Dermal, inhalation, ingestion, ocular
Carcinogenicity: Not designated as carcinogenic by NTP, IARC, or OSHA at this time
Mutagenicity: No available data suggest mutagenic effects for finished pharmaceutical
Reproductive Toxicity: Large doses may cause fetal harm; use under medical supervision by pregnant women
Environmental Fate: Active pharmaceutical ingredients like hydrocortisone sodium succinate may persist in aquatic environments
Ecotoxicity: Potential to disrupt aquatic life at low concentrations; exact LC50/EC50 values not well established
Mobility: Highly soluble and mobile in water; may leach into watercourses if released
Persistence and Degradability: Pharmaceutical steroids may resist rapid biodegradation; potential for bioaccumulation in sediment not well studied
Precautions: Never release large quantities into environment without appropriate treatment; comply with pharmaceutical waste management laws
Waste Treatment Methods: Dispose of unused material, contaminated packaging, and cleanup residues as pharmaceutical waste through a licensed chemical disposal contractor
Precautions: Prevent release into sewers, surface, or groundwater
Contaminated Packaging: Rinse and manage as hazardous pharmaceutical waste
Regulations: Comply with national or local hazardous waste regulations and best practice guidelines for corticosteroid disposal; seek incineration for total decomposition where available
UN Number: Not regulated for transport by road (ADR/RID), air (IATA/ICAO), or sea (IMDG) in supplied form
Transport Hazard Class: Not assigned—non-hazardous as a finished pharmaceutical product
Packing Group: Not assigned
Special Precautions: Ship in original, sealed containers to prevent contamination; shield from direct sunlight and excessive heat during transit; restrict to qualified handlers
Labeling: Ensure clear product labeling for identification by professionals in case of incidents in transit
Global Inventory Status: Listed under regulatory agencies governing pharmaceuticals, not listed as hazardous chemical
European Union: Regulated as medicinal product by EMA, no REACH restriction for medicinal use
United States: Regulated by FDA as prescription medicine; OSHA hazard communication applies for workplace handling
Handling Restrictions: Controlled under prescription-only and professional use; follow safe pharmaceutical handling procedures
Workplace Regulations: Workers must be trained under OSHA or local safety programs before handling; safety data and first aid information must be available to staff
Environmental Regulations: Comply with Clean Water Act, EPA guidelines on pharmaceutical disposal, and supplemental local regulations to prevent active pharmaceutical residues in the environment
