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Product Name: Hydrocortisone Sodium Phosphate
Chemical Family: Glucocorticoid; Corticosteroid
Synonyms: Hydrocortisone 21-(disodium phosphate); Cortisol sodium salt
CAS Number: 6000-74-4
Recommended Use: Pharmaceutical manufacturing, laboratory reagent
Manufacturer Information: Supplied by pharmaceutical chemical producers with dedicated contact lines for medical emergencies and technical support
Emergency Phone Number: Found on manufacturer’s label, typically staffed 24 hours a day for hazardous exposure events
GHS Classification: Not classified as hazardous under GHS for most uses but prolonged or high exposure may cause moderate irritation or sensitization
Hazard Statements: May cause eye and respiratory irritation; possible effects on immune response and endocrine systems with overexposure
Signal Word: Warning
Pictograms: Not required for typical pharmaceutical uses
Precautionary Statements: Keep away from food and drink; Avoid dust formation; Use in well-ventilated areas; Prevent skin and eye contact
Potential Health Effects: Eye, skin, and respiratory tract irritation; hormonal changes with significant or prolonged exposure
Target Organs: Eyes, skin, lungs, adrenal glands
Environmental Hazards: Limited data, but caution against release to waterways due to pharmaceutical activity
Chemical Name: Hydrocortisone Sodium Phosphate
Common Name: Cortisol sodium salt
Concentration: Typically pure, or found in solutions at specified concentrations printed on label
CAS Number: 6000-74-4
Impurities / Stabilizers: May contain residual water or buffer agents, none intentionally hazardous
Eye Contact: Rinse thoroughly with water for at least 15 minutes, keeping eyelids open; seek medical attention if irritation persists
Skin Contact: Wash with soap and water; remove contaminated clothing; medical attention may be necessary if rash or irritation develops
Inhalation: Move person to fresh air; assist breathing if necessary; consult a healthcare provider with any continued symptoms
Ingestion: Rinse mouth thoroughly, drink water, seek immediate medical evaluation, do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Watery eyes, irritation, or rash; hormonal or adrenal effects only with chronic or high exposures
Notes to Physicians: Treat symptomatically; monitor for allergic or endocrine effects in significant exposure cases
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Special Hazards: Possible emission of toxic fumes under combustion, including carbon oxides, phosphorus oxides, sodium oxides, and hydrogen chloride
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear
Specific Methods: Move uncontaminated containers away from fire area if safe; avoid breathing smoke, stay upwind; cool exposed containers with water spray
Personal Precautions: Use proper personal protective equipment (PPE); minimize generation of dust; avoid breathing any vapors or powder
Emergency Procedures: Evacuate area if necessary; contain spill to prevent spread; ventilate affected area
Methods for Containment: Sweep or vacuum up avoiding dust, transfer to suitable closed container for disposal
Clean-Up Methods: Wash spill area with water and detergent or mild disinfectant while avoiding contamination of waterways
Environmental Precautions: Prevent entry to drains, waterways, or soil, in keeping with good laboratory practices
Handling: Use in well-ventilated places; avoid aerosolization or dust formation; wear PPE such as gloves, lab coat, and eye protection; wash hands and exposed skin after handling
Storage: Store tightly closed in original container, in a cool, dry place; shield from light; keep separate from incompatible substances such as strong oxidizers; store away from food and beverages
Special Considerations: Keep container labeled and secure; avoid storage near moisture to prevent caking or degradation
Engineering Controls: Use chemical fume hood or local exhaust to control airborne levels; keep working surfaces easy to decontaminate
Respiratory Protection: Use appropriate masks if dust or aerosols are present and ventilation is inadequate
Skin Protection: Gloves recommended, especially when handling bulk amounts; use disposable nitrile or latex for routine procedures
Eye Protection: Safety goggles or face shield as needed for splash hazards
Other Protective Equipment: Lab coats, closed footwear; have eyewash and safety showers available
Exposure Limits: No occupational exposure limits set by OSHA, NIOSH, or ACGIH as of last review; minimize potential for chronic exposure nonetheless
Appearance: White or almost white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH (1% aqueous solution): Typically around 7-8
Melting Point: Decomposes without melting above 220°C
Boiling Point: Not available (decomposes)
Flash Point: Not applicable
Flammability: Not classified as flammable; dust form can present risk if finely divided in air
Solubility: Highly soluble in water; practically insoluble in organic solvents
Partition coefficient (log Pow): Unreported; generally low due to ionization
Vapor Pressure: Not volatile at ambient temperatures
Chemical Stability: Stable under recommended storage conditions
Reactive Hazards: Avoid strong oxidizers or reducing agents; prolonged exposure to moisture may cause gradual decomposition
Decomposition Products: Produces carbon oxides, phosphorous oxides, sodium compounds on combustion or decomposition
Polymerization: Does not undergo hazardous polymerization
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Acute Toxicity: Low for single dose exposure, based on animal studies; not acutely toxic at small doses intended for pharmaceutical use
Chronic Effects: Repeat exposure can influence cortisol levels, impact adrenal glands, or provoke immune or allergic responses
Skin Irritation: Possible with repeated or prolonged contact
Eye Irritation: May be irritating on direct contact
Inhalation: May cause respiratory irritation, especially if aerosolized
Sensitization: May provoke allergic reactions in sensitized individuals
Mutagenicity: No evidence of mutagenicity in in vitro or in vivo test systems reviewed to date
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Effects: High doses can impact hormonal regulation; reproductive toxicity not expected at low exposure levels
Ecotoxicity: Data limited; as a steroid, persistence in aquatic systems can disrupt endocrine function in wildlife at high concentrations
Persistence and Degradability: Expected to undergo slow degradation in natural environments; not readily biodegradable
Bioaccumulative Potential: Low due to hydrophilicity and rapid metabolism in most organisms
Mobility in Soil: Highly mobile in aqueous systems, less bound to particulate matter
Other Adverse Effects: Caution in large-scale pharmaceutical releases; instill best practices for discharge management
Waste Disposal Methods: Dispose as hazardous pharmaceutical waste according to local, state, and federal regulations; do not flush into waterways or municipal sewers
Contaminated Packaging: Triple rinse and incinerate or dispose through licensed contractor; follow label instructions for specific container disposition
Precautions: Avoid direct handling of waste, use gloves and eye protection during clean-up and disposal; keep disposal records for regulatory compliance where applicable
UN Number: Not regulated as a hazardous material for ground, air, or water transport in most jurisdictions
Proper Shipping Name: Hydrocortisone Sodium Phosphate (for reference in documentation)
Transport Hazard Class: None assigned
Packing Group: Not applicable
Special Precautions: Keep in securely closed, labeled containers; avoid moisture ingress and impact during transit
Other Transport Requirements: Ship according to standard requirements for non-hazardous chemicals; documentation of pharmaceutical grade and origin maintained with shipping papers if destination requires
Inventory Status: Listed or notified on major chemical inventories such as TSCA, EINECS, and DSL as pharmaceutical or research chemical
SARA Title III (Sections 311/312): Does not meet criteria for hazard classification as defined by hazard categories
California Proposition 65: Not listed as a carcinogen or reproductive toxicant
OSHA: Not regulated as hazardous but handle in accordance with good laboratory practices
Other Regulations: Transport and pharmaceutical control regulations vary; follow national and regional requirements for strict documentation and safe use
