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Product Name: Hydrocortisone Ester
CAS Number: 5404-29-7 (Hydrocortisone acetate, as an example)
Synonyms: Hydrocortisone 21-acetate, Cortisol acetate, Acetoxyhydrocortisone
Recommended Use: Pharmaceutical ingredient, anti-inflammatory steroid
Manufacturer: Information available on request
Emergency Contact: Local poison control center, or national emergency hotlines
Molecular Formula: C23H32O6
Molecular Weight: 404.5 g/mol
Supplier Contact: Information supplied with materials or purchase documentation
GHS Classification: Not classified as hazardous under GHS regulations for lab handling
Health Hazards: Prolonged skin contact may cause irritation or sensitization; eye contact may cause mild to moderate irritation; inhalation of dust can irritate respiratory tract; swallowing large amounts might impact hormone levels
Environmental Hazards: Potential risk to aquatic life through chronic exposure
Signal Word: No signal word required for lab-scale handling
Hazard Statements: May cause reproductive or developmental effects in high doses; possible endocrine disruption with chronic exposure
Precautionary Statements: Avoid unnecessary contact; prevent contamination of environment; use appropriate personal protective equipment
Chemical Identity: Hydrocortisone acetate or other hydrocortisone ester
Concentration: 98-100% (varies by lot and supplier)
Impurities: Trace organic solvents, moisture (<1%), and process-related byproducts reported in lab analysis
Additional Components: Typically none, unless formulated for medical dispensing
Structural Formula: Provided in technical documentation for regulated entities
Eye Contact: Rinse thoroughly with water for at least 15 minutes, keeping eyelids open; seek medical attention if irritation persists
Skin Contact: Wash with soap and water; remove contaminated clothing; seek medical advice if redness or rash develops
Inhalation: Move person to fresh air; seek medical attention if symptoms like coughing, shortness of breath, or chest discomfort persist
Ingestion: Rinse mouth with water; do not induce vomiting unless directed by medical professionals; seek immediate medical attention for large exposures
Medical Attention: Treat symptomatically; healthcare providers may monitor for adrenal suppression or endocrine effects in severe cases
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Strong water jet (risk of spreading powder)
Fire Hazards: Decomposes under high heat to release carbon oxides and unidentified organic compounds
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Special Procedures: Prevent run-off from entering drains or waterways
Combustion Products: Carbon monoxide, carbon dioxide, and possibly toxic fumes
Personal Precautions: Wear gloves, safety goggles, laboratory coat, and dust mask to avoid direct exposure
Spill Cleanup: Avoid raising dust; collect material with damp cloth or HEPA-filtered vacuum; place in sealed container for safe disposal
Environmental Precautions: Prevent spilled material from reaching watercourses or sewers
Decontamination: Clean contaminated surfaces with appropriate detergent, then rinse with water
Disposal: Dispose of collected material following local regulations for pharmaceutical waste
Handling: Keep containers tightly closed; use only in well-ventilated area; avoid breathing dust; avoid skin and eye contact; wash thoroughly after handling
Storage: Store below 30°C in a dry, well-ventilated location; protect from light and incompatible substances; keep away from strong oxidizing agents and moisture
Packaging Materials: Use original container or approved alternatives with secondary containment
Incompatibilities: Strong acids, bases, and oxidizers can degrade product
Occupational Exposure Limits: No specific threshold limit values; handle as a pharmaceutical active ingredient
Engineering Controls: Chemical fume hood or local exhaust ventilation recommended
Eye Protection: Safety goggles
Skin Protection: Nitrile gloves, laboratory coat or full-body protective clothing
Respiratory Protection: Dust mask or respirator rated for nuisance dusts (P2 or N95 recommended for routine weighing or handling)
Hygiene Measures: Wash hands, arms, and face after handling; prevent eating, drinking, or smoking in handling area
Physical State: White to off-white crystalline powder
Odor: Odorless or faint medicine-like odor
pH: Not applicable (insoluble in water)
Melting Point: 220-225°C (varies by specific ester)
Boiling Point: Decomposes before boiling
Solubility: Practically insoluble in water; soluble in ethanol, acetone, some oils
Vapor Pressure: Not significant at room temperature
Density: Approx. 1.3 g/cm³
Partition Coefficient (logP): 1.0–1.5 (depends on ester side chain)
Flash Point: Non-flammable as solid; no measurable flash point under normal conditions
Decomposition Temperature: >220°C
Chemical Stability: Stable under standard temperature and storage conditions
Reactivity: Non-reactive with most common laboratory materials
Hazardous Reactions: Strong oxidizers or acids can decompose product; forms adducts with reactive functional groups
Conditions to Avoid: Moisture, heat, light, and oxidizing environments
Hazardous Decomposition Products: Carbon oxides, acetic acid (for acetate esters), unknown organics
Acute Toxicity: Low estimated oral and dermal toxicity; LD50 (rat, oral) >2000 mg/kg for hydrocortisone analogues
Routes of Exposure: Inhalation, ingestion, skin or eye contact
Symptoms: Overexposure may lead to skin irritation, changes in mood or hormone levels, gastrointestinal upset, or eye discomfort
Chronic Effects: Repeated overexposure impacts endocrine system, can suppress adrenal function, may alter metabolic balance
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Sensitization: Not expected to sensitize in low-volume handling, but allergic reaction possible with repeated occupational exposure
Other Effects: Large exposures risk immune suppression or endocrine disruption
Ecotoxicity: Possible risk to aquatic organisms with long-term exposure to large quantities
Persistence and Degradability: Degrades slowly in environment; photodegradation and biodegradation possible but may accumulate
Bioaccumulation Potential: Low to moderate depending on environmental conditions
Mobility in Soil: Binds to organic matter; low likelihood of groundwater contamination under controlled disposal
Other Effects: Minimize release to environment, especially in bulk pharmaceutical manufacturing
Waste Disposal: Dispose as pharmaceutical waste following national, state, and local regulations
Container Disposal: Observe safe disposal of contaminated packaging; puncture-resistant containers preferred
Recycling: Not suitable for standard recycling streams; do not reuse empty containers
Precautions: Do not discharge to surface water, sewers, or landfill without proper treatment
Incineration: High-temperature incineration in an approved facility
UN Number: Not regulated as a dangerous good for air, sea, or ground transport under standard international codes
Proper Shipping Name: Hydrocortisone ester, non-hazardous chemical
Hazard Class: Not assigned
Packaging Group: Not assigned
Special Precautions: Prevent damage to containers; ship in secondary containment if large quantity
Transport Labeling: None required under current transport rules
International Regulations: Registered as an active pharmaceutical ingredient in many countries; subject to jurisdiction-specific drug regulations
OSHA Status: Not classified as hazardous substance for normal laboratory use; consult workplace health and safety protocols
TSCA Inventory: Hydrocortisone acetate and related esters generally listed
REACH Status: Exempt as active pharmaceutical ingredient; registration may apply to manufacturing intermediates
Other Regulations: Subject to good manufacturing practices (GMP) for finished pharmaceuticals; waste management requirements under local environmental law
Labeling Requirements: Product labeling follows national pharmaceutical and laboratory safety standards including hazard, precautionary, and first aid statements
