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Product Name: Hydrocortisone Acetate
Synonyms: Cortisol 21-acetate, 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
Chemical Formula: C23H32O6
CAS Number: 50-03-3
Recommended Use: Pharmaceutical corticosteroid, anti-inflammatory agent
Supplier Details: Manufacturer or distributor contact information includes address, emergency phone, technical support
Classification: May irritate eyes, skin, respiratory tract; possible reproductive hazard
Hazard Statements: Causes mild skin and eye irritation, chronic exposure linked with endocrine disruption, immunosuppressant effects
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, prevent contact with eyes/skin, wear recommended PPE
Pictograms: Exclamation mark indicates irritation, health hazard glyph for chronic effects
Chemical Name: Hydrocortisone Acetate
Concentration: >98% pure active pharmaceutical ingredient
Impurities: Typically less than 1% residual solvents or related corticosteroids
Molecular Weight: 404.5 g/mol
EINECS Number: 200-002-5
Inhalation: Get to fresh air, keep airways open, medical attention for symptoms like cough or respiratory distress
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing and wash before reuse, seek medical help for rash or irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, seek medical evaluation for persistent redness or discomfort
Ingestion: Rinse mouth, never induce vomiting, assess for systemic effects such as nausea or vomiting, immediate medical attention recommended
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical or foam
Unsuitable Media: High-pressure water direct streams may spread powder
Special Hazards: May produce toxic fumes such as carbon oxides on combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Fire-Fighting Methods: Control run-off water, cool containers if exposed to heat, evacuate personnel to a safe area
Personal Precautions: Limit exposure, use appropriate PPE including gloves and goggles, avoid dust formation
Environmental Precautions: Prevent entry to sewers or water systems, notify authorities in the event of large spills
Cleanup Procedures: Sweep up and collect powder using non-sparking tools, ventilate affected area, avoid generating airborne dust
Handling: Minimize dust, operate in well-ventilated environments, avoid eating or drinking in storage/handling areas, frequent handwashing after use
Storage: Keep containers tightly closed, store in cool, dry, well-ventilated locations, away from direct sunlight, heat sources, in original packaging
Incompatibilities: Strong oxidizers, acidic or basic conditions may degrade compound
Special Requirements: Secure storage for pharmaceuticals, restrict unauthorized access
Exposure Limits: No established occupational exposure limit; follow general pharmaceutical handling guidelines
Engineering Controls: Use enclosures, local exhaust or room ventilation, eyewash stations and safety showers recommended
Personal Protective Equipment: Eye protection with safety goggles, gloves made of nitrile or other chemical-resistant material, lab coat or protective clothing, fitted respiratory protection for airborne dust exposure
Hygiene Measures: No smoking, eating, or drinking in work areas, wash hands after handling, immediate disposal of contaminated materials
Appearance: White or off-white crystalline powder
Odor: Odorless or slight characteristic odor
pH: Practically neutral (aqueous suspension)
Melting Point: 225–230°C
Solubility: Practically insoluble in water, soluble in alcohol, acetone, chloroform
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not highly flammable
Partition Coefficient (logPow): 1.54
Vapor Pressure: Negligible at ambient temperatures
Chemical Stability: Stable under recommended conditions
Reactivity: Low reactivity with most substances at room temperature
Incompatible Materials: Strong oxidants, acids, alkalis
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, corrosive fumes on combustion or decomposition
Polymerization: Will not occur
Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg; not acutely toxic at ordinary exposures
Routes of Exposure: Inhalation, skin, eyes, ingestion
Effects of Exposure: Local irritation, possible systemic absorption with immunosuppression, hormone disruption at high or prolonged exposures
Chronic Effects: Adrenal suppression, gastrointestinal disturbance, skin thinning, increased infection risk with repeated/prolonged exposure
Carcinogenicity/Mutagenicity: No classified carcinogenic, mutagenic or teratogenic risks based on available studies
Reproductive Toxicity: High dose or chronic use can impair fertility, may affect fetus through maternal exposure
Ecotoxicity: Toxic to aquatic organisms at elevated concentrations; may disrupt endocrine function in wildlife
Persistence and Degradability: Degrades slowly in environment, persistent in soil and sediment
Bioaccumulation Potential: Low to moderate
Mobility in Soil: Low solubility reduces mobility, tends to remain in particulate phase
Other Adverse Effects: Pharmaceuticals in water bodies may impact aquatic species, important to limit release into environment
Waste Handling: Treat as hazardous pharmaceutical waste; segregate from regular waste
Methods of Disposal: Incinerate at certified facility, do not dump into drains, surface water, or soil
Contaminated Packaging: Dispose using same controls as for substance, minimize exposure to handlers
Local Regulations: Follow all local, regional, national regulations for pharmaceutical waste
UN Number: Not regulated for transport under UN recommendations
Proper Shipping Name: Hydrocortisone Acetate, not subject to stringent dangerous goods requirements
Packing Group: Not classified
Labels Required: None for most modes, but include pharmaceutical handling marks
Special Provisions: Prevent release of powder, use secure packaging to avoid spills, report significant transport incidents to authorities
Global Listings: Listed in pharmaceutical and chemical regulatory inventories
Occupational Safety: OSHA Hazard Communication Standard applies in workplace settings; use controls as recommended for reproductive hazards
Environmental Restrictions: Specific limits may apply under regional regulations for pharmaceuticals in water
Other Requirements: Check FDA, EMA, or local equivalents for purity, use, storage, disposal requirements
