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Product Name: Hydrochlorothiazide
CAS Number: 58-93-5
Synonyms: HCTZ, Esidrix, HydroDiuril, Oretic
Recommended Use: Pharmaceutical ingredient, primarily used as a diuretic and antihypertensive
Manufacturer: Refer to packaging or supplier documentation for specifics
Emergency Phone: Contact your local poison control center or health authorities for immediate help
Address: Details depend on the manufacturer; always check the packaging
Classification: Not classified as hazardous according to OSHA Hazard Communication Standard (29 CFR 1910.1200)
Signal Word: None required
Hazard Statements: May cause eye, skin, and respiratory irritation. Ingestion of large quantities may result in nausea or vomiting. Not combustible, but may decompose under fire conditions producing toxic gases.
Pictograms: None applicable
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Do not breathe dust. Practice good industrial hygiene. Wash hands after handling.
Chemical Name: Hydrochlorothiazide
Concentration: 100% (Active ingredient)
Molecular Formula: C7H8ClN3O4S2
Molecular Weight: 297.74 g/mol
Impurities: Trace manufacturing impurities may exist; refer to supplier’s certificate of analysis for specifics
Ingredient Transparency: No hazardous excipients or carriers often present in the bulk form
General: Move person away from exposure, seek medical attention as indicated
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if present and easy to do; seek medical advice
Skin Contact: Wash immediately with soap and water, remove contaminated clothing, consult medical support if irritation develops
Inhalation: Move victim to fresh air, provide artificial respiration if necessary, call for medical help if symptoms persist
Ingestion: Rinse mouth with water, never give anything to drink to an unconscious person, seek immediate medical attention
Symptoms: May include irritation, headache, nausea, and dizziness
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam; select agent appropriate for surrounding fire
Unsuitable Media: Avoid high pressure water jets as they could spread contamination
Specific Hazards: Decomposition may produce carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, hydrochloric acid fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Firefighting Instructions: Stay upwind, prevent run-off from entering drains or water sources, contain fire water if contaminated
Personal Precautions: Wear personal protective equipment including gloves, protective clothing, goggles, and a dust mask or respirator
Environmental Precautions: Prevent further leakage or spillage if it can be done without risk; do not allow into drains, water courses, or soil
Methods for Containment and Cleanup: Collect spillage using an inert absorbing material, place in a container for disposal, clean area with plenty of water, ventilate area and wash after complete cleanup
Decontamination: Use appropriate disinfectants if necessary
Reference to Other Sections: See Exposure Controls and Disposal Considerations for more information
Handling: Minimize dust generation and accumulation; avoid inhalation or direct contact; handle in well-ventilated areas or under local exhaust
Hygiene Practices: Wash thoroughly after handling, do not eat, drink, or smoke while working with open product
Storage Conditions: Store in tightly closed original container, in a cool, dry, well-ventilated area, away from incompatible materials like oxidizing agents
Storage Temperature: Room temperature (20-25°C/68-77°F) unless otherwise specified by the supplier
Shelf Life and Stability: Keep away from moisture; follow expiration dates provided by the manufacturer
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits for Hydrochlorothiazide
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels as low as possible
Personal Protective Equipment (PPE): Safety goggles or face shield, chemical-resistant gloves such as nitrile, lab coats or coveralls
Respiratory Protection: Use NIOSH-approved dust mask or respirator if exposure risk exists
Environmental Protection: Prevent release into the environment by using appropriate containment during transfer and clean-up
Appearance: White or almost white, crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Slightly acidic in solution
Melting Point: 273°C
Boiling Point: Not applicable (decomposes)
Solubility in Water: Practically insoluble, slightly soluble in acetone; soluble in dilute ammonia
Partition Coefficient (log Pow): -0.07
Vapor Pressure: Not available
Density: Approx. 1.6 g/cm³
Flammability: Not considered flammable
Evaporation Rate: Not applicable
Decomposition Temperature: Above melting point, releases toxic gases
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal conditions of use
Conditions to Avoid: Excessive heat, exposure to strong oxidizers or acids, moisture
Hazardous Decomposition Products: Oxides of carbon, nitrogen, sulfur, and hydrogen chloride gas under fire or extreme heat
Polymerization: Not known to occur
Material Incompatibilities: Strong oxidizing agents, strong acids
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 in rats estimated around 2750 mg/kg
Skin Irritation: May cause mild irritation
Eye Irritation: Can cause irritation on contact
Sensitization: Not expected based on available data
Chronic Effects: High or prolonged doses may impair kidney function or electrolyte balance
Carcinogenicity: Not classified as a carcinogen by IARC, ACGIH, NTP, or OSHA
Reproductive Toxicity: Data suggest possible risk at very high doses generally not encountered outside pharmaceutical overdose
Symptoms: Nausea, vomiting, dizziness, headache, skin rash, electrolyte disturbances on overdose
Ecotoxicity: Not expected to cause significant adverse effects to aquatic or terrestrial organisms at low concentrations
Aquatic Toxicity: Data limited, but should not be discharged into environment without treatment
Persistence and Degradability: Likely persistent based on chemical structure; not readily biodegradable
Bioaccumulation Potential: Low (log Pow -0.07 suggests low bioaccumulation)
Mobility in Soil: Limited due to low solubility in water, but precautions advised
Other Adverse Effects: Avoid large releases into the environment as good practice
Disposal Methods: Dispose of as special pharmaceutical or chemical waste in accordance with local, state, and federal regulations
Contaminated Packaging: Rinse container before disposal if permitted, otherwise treat as hazardous waste
Sewage Disposal: Do not discharge into sewers, waterways, or soil
Reuse/Recycling: Not recommended due to pharmaceutical activity
Incineration: Consider controlled incineration by licensed chemical waste disposal contractor
UN Number: Not classified as hazardous for transport under UN, IATA, or IMDG regulations
Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None assigned
Special Precautions: Minimize dust and avoid environmental release during transport. Use leak-proof sealed containers, keep away from food and animal feed during shipment.
OSHA Status: Not regulated as hazardous
TSCA: Listed
SARA Title III: Not subject to reporting under Sections 302, 304, 311, or 312
California Prop 65: Not listed
REACH Status (EU): Exempt as a pharmaceutical active ingredient
Inventory Status: Registered or pre-registered under chemical inventories in most major jurisdictions; check local requirements
Workplace Labelling: Use standard workplace labels indicating substance name, hazard details, and handling precautions
