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Product Name: Hydralazine Hydrochloride
Chemical Formula: C8H8N4•HCl
Synonyms: Apresoline hydrochloride, 1-hydrazinophthalazine hydrochloride
CAS Number: 304-20-1
Intended Use: Antihypertensive pharmaceutical, research chemical
Manufacturer Information: Listed on product packaging; ensure clear contact for emergencies
Emergency Telephone: Refer to local poison control or manufacturer emergency line
Recommended Restrictions: For laboratory, research, or prescription medical applications only
GHS Classification: Acute Toxicity Oral (Category 3), Skin Sensitization (Category 1), Eye Irritation (Category 2A), Specific Target Organ Toxicity - single exposure (Category 3)
Label Elements: Skull and crossbones for acute toxicity, exclamation mark for irritant and sensitization
Health Hazards: Harmful if swallowed, inhaled, or absorbed through skin; possible skin or eye irritation; may cause allergic reactions in susceptible individuals
Environmental Hazards: Toxic to aquatic life, especially in concentrated form
Risk Phrases: R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
Precautionary Statements: Avoid breathing dust; wash hands after handling; avoid release to the environment
Substance: Hydralazine Hydrochloride
Purity: ≥98% (dependent on source)
Chemical Identity: C8H8N4•HCl
Impurities: Trace related substances permitted by pharmacopeial specifications
Other Components: None required for intended use; excipients in pharmaceutical formulations not included here
Inhalation: Move person to fresh air and keep at rest; seek medical attention if symptoms like difficulty breathing or persistent cough develop
Skin Contact: Remove contaminated clothing, rinse exposed area thoroughly with soap and water; seek attention for persistent irritation
Eye Contact: Rinse cautiously with clean water for 15+ minutes, lifting eyelids periodically; remove contact lenses if possible
Ingestion: Rinse mouth thoroughly; seek immediate medical attention—do not induce vomiting unless directed by physician
Important Symptoms: Signs and symptoms may include headache, nausea, vomiting, low blood pressure, palpitations, allergic rash
Advice to Physician: Provide symptomatic and supportive treatment; monitor vital signs and cardiovascular status
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam to contain fire
Specific Hazards: May emit toxic fumes such as nitrogen oxides or hydrogen chloride on combustion
Advice for Firefighters: Wear full protective gear, including self-contained breathing apparatus; avoid inhaling combustion byproducts
Firefighting Procedures: Isolate hazard area; prevent run-off from entering drains or watercourses; cool exposed containers with water spray
Thermal Decomposition: Decomposes at elevated temperature producing hazardous gasses
Personal Precautions: Avoid dust generation; ventilate area; keep unprotected people away; wear gloves, mask, goggles, lab coat
Environmental Precautions: Contain spill; prevent material from entering soil, ditches, sewers, waterways
Spill Cleanup: Use an approved HEPA vacuum or dampen and scoop into sealable, labeled containers; wash spill site thoroughly post-cleanup
Disposal: Manage as hazardous waste; follow local regulations
Reporting: Notify safety officer and environmental authorities as applicable
Safe Handling: Work in well-ventilated space; avoid inhalation, ingestion, skin and eye contact; minimize dust generation
Storage Conditions: Store tightly sealed in original labeled container; keep away from incompatible substances (strong oxidizers, acids)
Temperature Recommendation: Maintain in a cool, dry environment, preferably between 15-30°C
Protection Against Static: Prevent electrostatic build-up where dust may be present
Segregation: Separate from food, drink, and incompatible substances
Additional Measures: Use only by qualified personnel
Occupational Exposure Limits: No specific limits set by OSHA; minimize exposure as low as reasonably achievable
Engineering Controls: Fume hood or local exhaust ventilation recommended for open handling
Respiratory Protection: Approved HEPA respirator required if dust formation is possible
Eye Protection: Chemical safety goggles or face shield
Skin Protection: Nitrile gloves, lab coat, and suitable protective clothing
Hygiene Measures: Wash hands before eating, drinking, or leaving the laboratory; do not pipette by mouth
Appearance: White to off-white crystalline powder
Odor: No characteristic odor
pH (solution): 3-5 (for aqueous solution)
Melting Point: 273–277°C (with decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Freely soluble in water; sparingly soluble in alcohol
Vapor Pressure: Not significant at room temperature
Density: ~1.6 g/cm³
Partition Coefficient: Not available
Flammability: Not flammable, but combustible
Other Data: Stable under recommended storage conditions
Chemical Stability: Stable in solid form under standard conditions of handling and storage
Reactivity: No dangerous reactions in normal use; keep away from strong oxidizers and acids
Decomposition Products: Hazardous gases (nitrogen oxides, hydrogen chloride) possible upon decomposition
Hazardous Polymerization: Will not occur
Conditions to Avoid: Excessive heat, incompatibles, prolonged exposure to light or air
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Acute Toxicity: LD50 (oral, rat): 50–100 mg/kg; can be toxic in large doses to mammals
Chronic Effects: Prolonged or repeated exposure may cause immune system effects, skin sensitization
Symptoms: Headache, nausea, vomiting, hypotension, allergic dermatitis, fever, muscle pain
Carcinogenicity: Not classified as carcinogen by IARC, ACGIH, NTP, OSHA
Mutagenicity: Reports suggest positive results in some assays
Teratogenicity: Data insufficient for robust conclusion; animal studies limited
Toxicity to Aquatic Life: Harmful in concentrated form, especially before degradation
Persistence and Degradability: Partial degradation in environment; not considered persistently bioaccumulative
Mobility in Soil: Moderate\n
Bioaccumulation: Low potential
Other Adverse Effects: May cause adverse effects on microbial activity in aquatic or soil environments
Waste Disposal Methods: Dispose of as hazardous pharmaceutical waste in accordance with local, regional, national, and international laws
Container Disposal: Triple rinse containers, puncture, and send to chemical waste facility
Precautions: Use qualified incineration facility where available; avoid discharge to natural waters
Residue Handling: Avoid contact with residue; handle with PPE
UN Number: Regulated under chemical product classification; refer to shipping documents
Proper Shipping Name: Hydralazine Hydrochloride
Transport Hazard Class: Toxic substances, based on concentration and form
Packing Group: III (for toxic solids, specify with carrier)
Environmental Hazards: Not a marine pollutant by regulation, but avoid bulk spillage
Transport Precautions: Package securely, separate from food and compatible groups
TSCA Status: Listed
EC Regulation: Included on EINECS (European Inventory of Existing Commercial Chemical Substances)
OSHA Regulation: Classified as hazardous by OSHA Hazard Communication Standard
WHMIS Classification: D2B - Toxic material
Hazard Label: OSHA-compliant labels required
REACH Status: Exempted for pharmaceutical-use intermediates and finished products
Other Provisions: Follow national and local chemical safety, environment, and workplace regulations
