© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Histamine Diphosphate
Synonyms: Histamine Phosphate, 2-(1H-imidazol-4-yl)ethylamine diphosphate
CAS Number: 51-74-1
EC Number: 200-132-2
Molecular Formula: C5H9N3 • 2H3PO4
Molecular Weight: 268.13 g/mol
Recommended Use: Laboratory chemical, research, pharmaceutical applications
Supplier: Major chemical providers, research supply companies
Emergency Contacts: National Poison Center, local emergency number
Classification: Acute toxicity (Oral, Dermal), Skin and eye irritant, Sensitization possible on prolonged exposure
GHS Label: Warning
Hazard Statements: Harmful if swallowed or inhaled, causes skin and serious eye irritation, may cause allergic skin reaction
Precautionary Statements: Avoid breathing dust or fumes, wear eye protection, use gloves, wash thoroughly after handling
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: Irritation to eyes, skin, respiratory tract; allergic reactions, headache, dizziness
Symptoms: Redness, tearing, pain on contact; nausea, vomiting if ingested; coughing, shortness of breath on inhalation
Chemical Name: Histamine Diphosphate
Common Name: Histamine Phosphate
CAS Number: 51-74-1
Concentration: 98-100%
Impurities: Trace amounts of related phosphates may be present
Additives: No known preservatives, stabilizers present
Physical Form: White to off-white crystalline powder
Inhalation: Move person to fresh air, monitor breathing, use artificial respiration if not breathing, seek medical help
Skin Contact: Remove contaminated clothing, rinse affected skin with water and soap for at least 15 minutes, get medical attention if irritation persists
Eye Contact: Rinse cautiously with water for 15-20 minutes, remove contact lenses, consult an eye doctor
Ingestion: Rinse mouth, do not induce vomiting unless advised by a medical professional, call poison control immediately
Notes for Physicians: Symptomatic treatment, monitor for signs of allergic reaction or systemic effects
Suitable Extinguishing Media: Use carbon dioxide, dry powder, water spray, or foam for surrounding fires
Hazards from Combustion: Produces toxic fumes including carbon oxides, nitrogen oxides, and phosphorus oxides
Protective Equipment: Firefighters use NIOSH-approved self-contained breathing apparatus, full protective clothing
Precautions: Prevent runoff from entering drains or waterways, keep containers cool with water spray
Unusual Fire Hazards: Dust buildup can increase fire risk in confined spaces
Personal Precautions: Evacuate area, avoid dust formation, ventilate area, wear protective gloves and eye protection
Environmental Precautions: Prevent release into soil, waterways, and drains
Spill Clean-up Methods: Sweep up material without creating dust, collect for safe disposal, wash spill site after material pickup
Waste Disposal: Dispose of in accordance with local, regional, and national regulations for hazardous chemicals
Precautions for Safe Handling: Use only in well-ventilated areas, avoid contact with eyes, skin, and clothing, do not eat or smoke during use
Conditions for Safe Storage: Store in tightly closed containers, keep in a dry, cool, well-ventilated space, keep away from incompatible materials such as strong oxidizing agents
Storage Temperature: Recommended to store between 2°C to 8°C
Incompatibles: Strong bases, oxidizers, and reactive metals
Special Handling Advice: Use non-sparking tools and ground containers when transferring large amounts
Occupational Exposure Limits: No specific OSHA, NIOSH, or ACGIH exposure limits established
Engineering Controls: Use local ventilation or fume hood, eye wash stations, safety showers
Personal Protective Equipment: Chemical-resistant gloves, laboratory coat, safety goggles
Respiratory Protection: Use dust mask or respirator for high concentrations, particularly in powder form
Hygiene Measures: Wash hands thoroughly after handling, launder contaminated clothing before reuse
Appearance: White to almost white crystalline powder
Odor: Slight distinctive odor
Odor Threshold: Not available
pH: Approximately 3.5 (for 1% solution)
Melting Point: 256°C (decomposes)
Boiling Point: Not applicable
Flash Point: Not combustible
Flammability: Not flammable in solid form
Vapor Pressure: Negligible
Solubility: Soluble in water, practically insoluble in organic solvents
Partition Coefficient: Not available
Evaporation Rate: Not applicable
Viscosity: Not applicable
Relative Density: Around 1.7 (water = 1)
Chemical Stability: Stable under recommended storage conditions
Reactivity: Avoid contact with strong alkalis or oxidizers, as it may react aggressively
Hazardous Reactions: May react with some metals, acids, and oxidizers
Decomposition Products: Produces nitrogen oxides, phosphorus oxides, carbon oxides under fire or strong heat
Polymerization: Will not occur under normal handling
Acute Toxicity: Low to moderate toxicity; estimated oral LD50 for rats: 1000-2000 mg/kg
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms of Exposure: Irritation, reddening, coughing, nausea, headache
Chronic Toxicity: Repeated exposure may produce sensitization reactions
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: No data indicating mutagenic effects in standard tests
Reproductive Toxicity: No evidence of reproductive or developmental toxicity in animal experiments
Ecotoxicity: Data limited, expected to be slightly toxic in aquatic environments
Persistence and Degradability: Expected to degrade quickly in soil and water
Bioaccumulative Potential: Log Kow < 1, considered low
Mobility in Soil: High mobility, soluble in water, may leach into groundwater
Other Adverse Effects: No ozone depletion or greenhouse gas hazard
Aquatic Toxicity: Low toxicity to fish and invertebrates but avoid significant environmental release
Safe Disposal Methods: Place in sealed containers for chemical waste, treat as hazardous material
Laws and Regulations: Follow national, regional, and local hazardous waste requirements
Recommendations: Do not flush into surface water or sanitary sewer, consult waste contractor for safe incineration
Reuse or Recycling: Not advised due to contamination risk
UN Number: Not listed under standard dangerous goods codes
DOT Classification: Not regulated for ground transport in small quantities
IMDG/IATA: Not classified as a dangerous good for sea or air transport
Packaging Requirements: Must use non-breakable, leak-proof containers, inner packaging secured
Special Precautions: Avoid physical damage, do not transport with incompatible substances
Handling During Transport: Shield from direct sunlight, protect from dampness and contamination
Labelling Requirements: Complies with GHS labeling, signal word: Warning
International Inventories: Listed in chemical substance inventories (e.g., TSCA, EINECS/ELINCS)
SARA Title III (Sections 311/312): Classified as acute health hazard
OSHA Hazardous Chemical: Covered under OSHA Hazard Communication Standard
REACH: Exempted for research purposes below certain annual tonnage limits
Canadian WHMIS: D2B - Toxic Material causing other toxic effects
California Proposition 65: Not listed as carcinogen or reproductive toxin
Other Regulations: Users handle and review local guidelines for chemical handling, storage, and disposal
