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Product Name: Histamine Dihydrochloride
Synonyms: 2-(Imidazol-4-yl)ethylamine dihydrochloride
Recommended Use: Laboratory reagent, pharmaceutical intermediate
CAS Number: 56-92-8
Molecular Formula: C5H9N3·2HCl
Molecular Weight: 184.07 g/mol
Supplier Information: Manufacturer’s address and emergency contact number provided on outer packaging and invoice
Emergency Contact: Refer to local and national emergency numbers provided by supplier
Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2A, Skin Irritation Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Wear protective gloves, protective clothing, and eye protection. Avoid breathing dust or powder. Wash hands thoroughly after handling. Do not eat, drink, or smoke during use.
Symptoms of Exposure: Burning sensation, redness, cough, headache, nausea, vomiting, irritation of eyes/skin/respiratory tract.
Chemical Name: Histamine Dihydrochloride
Concentration: 99% or greater
CAS Number: 56-92-8
Hazardous Components: No additional hazardous substances present
Inhalation: Move person to fresh air. Monitor breathing and provide oxygen if available and symptoms are severe. Seek medical attention if irritation persists.
Skin Contact: Wash with plenty of soap and water for at least 15 minutes. Remove contaminated clothing. Seek medical attention for persistent redness or irritation.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek immediate medical attention.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting unless directed by medical personnel. Drink water if conscious. Seek medical attention.
Most Important Symptoms: Irritation, cough, redness, headache, gastrointestinal distress.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Strong jets of water may spread the product
Specific Hazards Arising from the Substance: Combustion may release toxic fumes of nitrogen oxides, hydrogen chloride, carbon oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear
Firefighting Instructions: Evacuate area, approach upwind, avoid contact with skin and eyes, cool containers exposed to flame with water spray.
Personal Precautions: Wear chemical-resistant gloves, protective eyewear, and lab coat. Avoid dust. Ventilate area.
Environmental Precautions: Prevent powder from entering drains and water sources.
Cleanup Methods: Sweep up and place in suitable closed container for disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup.
Decontamination: Wash affected surfaces with water and detergent.
Precautions for Safe Handling: Handle in well-ventilated area. Avoid breathing dust. Use suitable protective equipment. Do not eat, drink, or smoke near product. Wash hands after use.
Storage Conditions: Store in tightly closed container in cool, dry, well-ventilated place. Keep away from incompatible materials, moisture, acids, and oxidizers.
Specific End Use: Use strictly according to manufacturer’s recommendations and laboratory protocols.
Incompatibilities: Strong bases, oxidizing agents.
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits.
Engineering Controls: Use local exhaust ventilation or work in a chemical fume hood to minimize airborne exposure.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or PVC), safety goggles, long-sleeved lab coat, if splashing possible use face shield, use dust mask or P2 dust respirator if exposure is likely.
General Hygiene: Wash hands after handling. Avoid food and drink in work area.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic
Odor Threshold: Not determined
pH: Typically acidic when dissolved in water
Melting Point/Freezing Point: 248 – 250°C (decomposes)
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Evaporation Rate: Not measurable for solid
Flammability: Not classified as flammable
Vapor Pressure: Not applicable for solid
Relative Density: Approximately 1.7 g/cm³ (literature)
Solubility: Soluble in water
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Decomposes above melting point
Viscosity: Not applicable
Chemical Stability: Stable under recommended conditions of use and storage
Possibility of Hazardous Reactions: Strong acids, strong oxidizers may cause hazardous reactions
Conditions to Avoid: Heat, moisture, direct sunlight
Materials to Avoid: Oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride gas, carbon monoxide, carbon dioxide
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Moderate; LD50 (oral, rat or mouse) between 83 mg/kg and 500 mg/kg as per published data
Skin Corrosion/Irritation: Causes skin irritation
Eye Damage/Irritation: Causes serious eye irritation
Respiratory or Skin Sensitization: Not expected to be a sensitizer
Chronic Effects: Prolonged exposure may affect respiratory system and central nervous system
Symptoms: Nausea, headache, dizziness, shortness of breath, rash, conjunctivitis
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Other Effects: May intensify allergic or asthmatic symptoms in sensitive individuals
Ecotoxicity: Limited data available; not expected to bioaccumulate or persist in environment at low concentrations
Aquatic Toxicity: Expected low hazard to aquatic organisms based on solubility and dilution; release in large amounts can affect water pH and biological oxygen demand
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Does not bioaccumulate
Mobility in Soil: Expected to have high mobility in water due to solubility
Other Adverse Effects: Avoid uncontrolled release into soil or waterways to prevent local effects
Disposal Methods: Dispose of in accordance with local, regional, and national regulations. Place solid waste in sealed, properly labeled containers for disposal at a licensed chemical waste site. Avoid release into environment.
Contaminated Packaging: Rinse thoroughly and manage as hazardous waste. Consult licensed waste disposal contractor for proper handling and recycling of materials if possible.
Special Precautions: Do not flush down drains or mix with household waste. Keep waste segregated until proper disposal.
UN Number: Not classified as a dangerous good under UN transport regulations
Proper Shipping Name: Histamine Dihydrochloride
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Labels Required: No hazard label required for ground, air, or sea transport according to latest available regulatory databases
Environmental Hazards: Not environmental hazard in transport
Special Transport Precautions: Keep in tightly sealed containers, protect from moisture, segregate from incompatible substances during transportation
OSHA Status: Not specifically regulated
SARA Title III: Not listed as an extremely hazardous substance or Section 313 chemical
TSCA Listing: Listed on United States TSCA inventory
DSL/NDSL (Canada): Present
EINECS/ELINCS (EU): Listed (EC No.: 200-288-5)
REACH Status: Exempt or preregistered for pharmaceutical research use
Other National Regulations: Complies with local chemical safety regulation where imported or used
Inventory Status: Registered or notified in most jurisdictions including US, EU, Japan, South Korea, China, Australia
Other Regulatory Info: Refer to specific country requirements for workplace controls, environmental release, or monitoring
