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Product Name: Hirudin
Synonyms: Leech anticoagulant, recombinant hirudin
Chemical Family: Protein, peptide
Molecular Formula: C287H440N80O110S6
Chemical Structure: Polypeptide, 65 amino acids
Intended Use: Anticoagulant, biochemical research, pharmaceutical ingredient
Manufacturer Information: Contact details supplied by the production facility or test laboratory
Emergency Phone Number: Supplied by the responsible chemical provider
GHS Classification: Not classified as hazardous according to GHS criteria for pure proteins
Physical Hazards: Not flammable, negligible explosion risk
Health Hazards: Risk of allergic reactions, risk of prolonged bleeding on contact with bloodstream, potential inhalation of dust and powder causing respiratory irritation
Environmental Hazards: Not expected to create significant risk under usual handling, avoid large-scale releases
Signal Word: None required
Hazard Statements: May cause allergy and bleeding complications in susceptible individuals
Precautionary Statements: Wear respiratory protection, prevent contact with open wounds, avoid environmental release
Substance: Hirudin
CAS Number: 113274-56-9
Concentration: Typically supplied as >95% pure
Impurities: Trace levels of fermentation byproducts or host cell proteins (if recombinant production), amounts vary by batch and supplier
Other Ingredients: May contain stabilizers, buffer salts if provided as a formulated product
Physical Form: Lyophilized powder, aqueous solution, or injectable vial form
Eye Contact: Rinse cautiously with water for 15 minutes, seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, monitor for symptoms of bleeding or allergic reaction
Inhalation: Move person to fresh air, monitor for breathing difficulty, seek medical advice if irritation or allergic symptoms occur
Ingestion: Rinse mouth with water, get medical help if symptoms develop, do not induce vomiting
Notes for Physicians: Monitor coagulation parameters, symptomatic and supportive care only as antidote not available
Immediate Medical Attention: Indicated for significant exposure and any signs of bleeding, respiratory distress, or allergic response
Suitable Extinguishing Media: Water spray, foam, carbon dioxide (CO₂), dry chemical
Unsuitable Extinguishing Media: None identified
Specific Hazards: Does not sustain combustion, thermal decomposition may release carbon oxides and nitrogen oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus (SCBA) and full protective clothing
Special Procedures: Prevent water runoff from entering drains or waterways, collect contaminated water separately
Personal Precautions: Use appropriate personal protective equipment (PPE), including gloves, lab coat, respiratory protection if dusting possible
Environmental Precautions: Keep away from drains, surface water, and groundwater, contain spills
Cleanup Methods: Sweep up without creating dust, wipe with damp cloth, dispose in accordance with regulations
Disposal of Contaminated Material: Place waste in labeled containers for safe disposal, minimize environmental release
Emergency Procedures: Evacuate unprotected personnel, ventilate area thoroughly, alert response personnel as appropriate
Safe Handling: Work in well-ventilated environments, avoid direct contact with the substance, do not eat or drink while handling the material
Technical Precautions: Use only with suitable containment, handle under local exhaust or fume hood
Storage Conditions: Store at recommended temperature (usually -20°C or lower for lyophilized form), protect from light and moisture
Incompatibilities: Keep away from acids, oxidizers, and any contaminating biological materials
Packaging Materials: Store in sealed, labeled containers made from materials compatible with biochemicals
Special Requirements: Restrict access to authorized staff, keep log of inventories and movements for regulatory compliance
Exposure Limits: No established Occupational Exposure Limits for proteins like hirudin
Engineering Controls: Employ local exhaust ventilation, cabin enclosures or biosafety cabinets in case of large quantities
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile or latex), safety goggles, lab coat or gown, N95 or equivalent respirator if airborne powder possible
Hygiene Measures: Wash hands after handling, do not touch face or exposed skin
Control of Environmental Exposure: Avoid release to sewage system, monitor effluent for any active compound
Appearance: White to off-white lyophilized powder or clear colorless solution
Odor: Odorless
pH: Neutral to slightly acidic (5–7 for aqueous solutions)
Melting Point: Not applicable for proteins
Boiling Point: Not applicable
Solubility in Water: Fully soluble
Vapor Pressure: Not volatile
Density: Not determined due to solid nature
Partition Coefficient: Not relevant for macromolecules
Decomposition Temperature: Above 60°C
Flash Point: Not applicable
Evaporation Rate: Not applicable
Viscosity: Not significant at normal concentrations
Chemical Stability: Stable under recommended storage conditions, loses activity if repeatedly freeze-thawed
Conditions to Avoid: Prolonged exposure to air, light, high temperatures
Incompatible Materials: Strong acids, oxidizers, biological contaminants
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides on burning
Polymerization: Does not occur
Acute Toxicity: Low oral and dermal toxicity based on available research, proteinaceous compounds are unlikely to be absorbed in harmful amounts unless injected
Chronic Toxicity: Prolonged contact might cause sensitization and allergy
Potential Routes of Exposure: Skin, eyes, inhalation, accidental injection
Symptoms of Exposure: Bleeding, bruising, allergic symptoms such as rash or difficulty breathing in sensitive individuals
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: No evidence from existing literature
Reproductive Toxicity: No data indicating reproductive risk
Target Organs: Blood clotting system, immune system in those predisposed
Eco-toxicity: Not expected to be toxic to aquatic or terrestrial organisms in environmental concentrations used in research or medicine
Persistence and Degradability: Expected to degrade through natural biological processes, peptide bonds cleaved by proteases
Bioaccumulation Potential: Unlikely due to size and rapid degradation by natural organisms
Mobility in Soil: Relatively immobile, binding to soil and rapidly broken down
Other Adverse Effects: Large scale releases should be avoided due to unknown risk of affecting local blood-feeding wildlife or aquatic systems
Waste Disposal Methods: Collect residuals and contaminated materials in suitable containers, hand over to licensed chemical waste disposal companies
Incineration: Permitted with high-temperature facilities, ensure complete destruction
Avoided Disposal Methods: Release into sewage or waterways
Contaminated Packaging: Decontaminate by autoclave or incinerate as biomedical waste
Special Considerations: Dispose according to local, regional, and national regulations for protein and research chemical waste
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Special Precautions: Store and ship at recommended temperatures, avoid temperature fluctuations, avoid rough handling
Notes: Label containers clearly, accompany with safety data information in shipment documentation
Occupational Safety and Health: Not specifically regulated by OSHA for exposure to proteins, general laboratory safety standards apply
TSCA Listing: Not listed
IATA / DOT Classification: Not regulated as a hazardous substance during air, road, or sea transport
Other Regulations: Comply with local biohazard and chemical safety laws, research institutions may have stricter protocols
Labeling Requirements: Clearly display product name, batch number, manufacturer, hazard warnings on all primary and secondary containers
Training Requirements: Staff handling the substance should receive training on safe use, emergency procedures, and PPE
