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Product Name: High-Substituted Hydroxypropyl Cellulose
Chemical Family: Cellulose Ether
Synonyms: Hydroxypropyl Cellulose, HPC
Recommended Use: Thickener, binder, film former, stabilizer in pharmaceuticals, cosmetics, food, industrial applications
Manufacturer: Contact details and emergency telephone of supplier listed on packaging
CAS Number: 9004-64-2
Product Form: Powder, white to off-white
Contact for MSDS: Safety Department, manufacturer provided
GHS Classification: Not classified as hazardous under GHS regulations
Physical State: Solid powder
Route of Entry: Inhalation, skin, eye contact, ingestion
Hazard Statements: Dust may cause mechanical irritation to respiratory tract, eyes, and skin
Signal Word: None required
Precautionary Statements: Avoid creating dust. Use local exhaust ventilation. Wear eye protection if airborne dusts form.
Potential Health Effects: Long-term exposure may dry or irritate skin
Environmental Hazards: May contribute to local turbidity in water streams
Chemical Name: High-Substituted Hydroxypropyl Cellulose
CAS Number: 9004-64-2
Content Range: 95–100% by weight
Impurities: Trace sodium chloride, sodium glycolate
Additives: None intentionally added or required for formulation
Inhalation: Move person to fresh air. Give water if throat irritation persists. Seek medical attention if symptoms do not resolve.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if easy to do. Keep rinsing until feeling of scratchiness fades.
Skin Contact: Wash skin thoroughly with soap and water. Remove contaminated clothing and launder before reuse.
Ingestion: Rinse mouth. Not expected to be toxic; give water to drink. If discomfort or unusual symptoms develop, get medical help.
Acute Symptoms: Dust may irritate eyes, nose, and respiratory tract.
Notes for Doctors: No specific antidote. Treat symptomatically. Product is not absorbed systemically.
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: High-pressure water jets may scatter dust
Special Hazards: Powder may form combustible dust clouds in air. Combustion releases carbon oxides.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective suit.
Advice for Firefighters: Cool containers near to fire with water. Remove product from fire area if safe.
Unusual Hazards: Avoid inhaling smoke from burning material.
Personal Precautions: Avoid breathing dust. Use appropriate PPE—gloves, safety glasses, suitable mask.
Environmental Precautions: Prevent large spills in waterways. Material is non-toxic but can contribute to turbidity.
Containment: Sweep or vacuum up spilled powder. Avoid generating dust clouds.
Methods for Clean-up: Use wet methods or industrial vacuum cleaners equipped with HEPA filtration. Collect in sealed containers.
Disposal: Place waste into suitable, labeled container for recovery or disposal.
Handling: Keep the work area clean. Minimize dust formation. Avoid sources of ignition. Wash hands after handling.
Storage Conditions: Store in original containers tightly closed in dry, cool, well-ventilated space. Keep away from strong oxidizers.
Packaging: Multilayer paper bags, fiber drums, or polyethylene-lined containers
Incompatibilities: Oxidizing agents
Special Requirements: Store away from food and drink. Routine housekeeping limits slip hazards.
Occupational Exposure Limits: Nuisance dust, OSHA PEL (8-hour TWA): 15 mg/m³ total dust, 5 mg/m³ respirable fraction
Engineering Controls: Use process enclosures or local exhaust extraction to reduce airborne dust levels.
Personal Protection: Wear dust-proof goggles, lightweight gloves, and a NIOSH-approved particulate respirator if dust exceeds occupational limits.
Hygiene Practices: Remove soiled clothing and wash before reuse. Wash hands and face before breaks and after work.
Environmental Exposure: Keep dust away from drains and water sources.
Appearance: White or off-white odorless powder
Molecular Weight: Varies depending on substitution degree, typically 80,000–1,000,000
pH (1% solution): 5.0–8.5
Odor: None
Melting Point: Not applicable—decomposes before melting
Solubility: Readily soluble in cold water; insoluble in most organic solvents
Density: 1.12–1.20 g/cm³
Bulk Density: 0.35–0.60 g/cm³
Flash Point: Not applicable
Autoignition Temp: >200°C
Decomposition Temperature: >200°C
Explosive Properties: Dust can form combustible mixtures with air
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not reactive under normal conditions
Hazardous Reactions: Not known to react dangerously with other chemicals in routine environments
Incompatible Materials: Strong oxidizers may degrade or ignite product
Hazardous Decomposition Products: Thermal breakdown produces carbon monoxide, carbon dioxide
Conditions to Avoid: High heat, sparks, flame, formation of airborne dust clouds
Acute Toxicity: Data shows no acute toxicity via oral, dermal, or inhalation routes
Skin Corrosion/Irritation: Not an irritant (tested in rabbits)
Eye Damage/Irritation: Mild mechanical irritation possible
Respiratory or Skin Sensitization: No sensitization reported in studies or industrial use
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, ACGIH, or OSHA
Mutagenicity & Reproductive Toxicity: Negative in available studies
Chronic Effects: No chronic health effects identified from repeated exposure
Target Organs: None identified
Aquatic Toxicity: Low solubility product does not bioaccumulate or exhibit toxicity to fish and aquatic organisms
Persistence and Degradability: Biodegradable through common environmental processes
Bioaccumulation Potential: Not expected to bioaccumulate in food chains
Mobility in Soil: Moderate mobility in water, slow leaching through soil
Other Hazardous Effects: No evidence of harm to wildlife or insects, breaks down to harmless products in environment
Waste Disposal Methods: Dispose by landfill in accordance with local regulations for non-hazardous solid waste. Material is fully biodegradable and does not require special treatment.
Container Disposal: Thoroughly empty bags or drums before recycling or disposal. Rinse containers if required by local regulation.
Incineration: Suitable for incineration with energy recovery; combustion products are not classified as hazardous.
Special Precautions: Prevent dust emissions during waste handling. Avoid release of large quantities to sewers.
UN Number: Not regulated as dangerous goods
UN Proper Shipping Name: Not applicable
Transport Hazard Class: No hazard classification
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions: Avoid container damage during transit to prevent leaks of dust
Label: No special labeling required under transport regulations
OSHA: Not considered a hazardous substance
TSCA Inventory: Listed
REACH Status: Exempt from registration as a polysaccharide
FDA: Approved for specific uses in food, pharma, and cosmetics
Canada DSL: Listed
Other Global Inventories: Compliant in Japan, China, Australia, EU
Hazard Symbols: None
Risk/Safety Phrases: None assigned
Worker Protection: General ventilation and workplace hygiene satisfactory for handling under normal conditions
