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Product Name: Halometasone
Chemical Name: 21-Chloro-9α-fluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
Synonyms: Halomethasone, Halometasona, CP 217
CAS Number: 50629-82-8
Recommended Use: Active pharmaceutical ingredient, corticosteroid
Supplier: Pharmachemical manufacturer or distributor contact details per shipment
Emergency Contact: Refer to local country emergency numbers listed on packaging or product documentation
Classification: Not classified as hazardous under GHS guidelines for finished dosage forms, but raw powder carries potential for respiratory and skin sensitization
Physical Hazards: Possible dust explosion hazard if suspended in air at high concentrations
Health Hazards: Inhalation, ingestion, or skin contact risks include corticosteroid-related effects such as skin thinning, immunosuppression, potential endocrine disruption
Environmental Hazards: Potential persistence in soil and water, risk to aquatic organisms
Signal Word: Warning
Hazard Statements: Causes skin irritation, may cause respiratory irritation, may be harmful to aquatic life
Pictograms: Exclamation mark, environment (where required)
Chemical Identity: Halometasone
Concentration: >99% pure active ingredient in primary packaging
Impurities: Trace pharmaceutical production residues less than 1%
Other Ingredients: None in raw form; excipients in finished pharmaceutical products vary by manufacturer
Inhalation: Move to fresh air immediately. Seek medical attention if symptoms like coughing, sore throat, or irritation occur.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Get medical attention if persistent irritation or signs of allergic reaction develop.
Eye Contact: Rinse eyes carefully with plenty of water for several minutes, hold eyelids open. Remove contact lenses if present and easy to do; continue rinsing.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Consult a doctor immediately and provide product label or safety data.
Most Important Symptoms/Effects: Steroid exposure concerns—localized or systemic steroid reactions, irritation, allergic response.
Extinguishing Media: Suitable for powder fires: water spray, dry chemical, carbon dioxide, or foam
Unsuitable Media: Avoid high-pressure water jets
Fire Hazards: Produces toxic fumes under fire conditions including hydrogen chloride, hydrogen fluoride, carbon oxides
Protective Equipment: Self-contained breathing apparatus, full protective suit
Special Procedures: Cool containers with water, contain runoff, avoid inhaling combustion gases
Personal Precautions: Wear respiratory protection (P3 filter), glove, protective clothing, and eye protection
Environmental Precautions: Prevent product from entering drains, water courses, or soil; alert authorities if spillage contaminates environment
Cleanup Methods: Ventilate area, clean up using HEPA-filter vacuum or damp cloths to minimize dust; collect in appropriate containers for disposal; wash spill site with water after removal
Safe Handling: Work in well-ventilated space or suitable containment. Minimize dust generation, avoid all unnecessary contact. Do not eat, drink, or smoke while handling.
Storage Conditions: Store below 25°C (77°F), protect from moisture and light, keep in tightly closed original container
Incompatibilities: Store separately from oxidizing agents, acids, alkali substances
Special Precautions: Post warning signage in storage and handling areas; restrict access to trained personnel
Engineering Controls: Local exhaust ventilation, process enclosures, fume hoods where possible
Exposure Limits: No official occupational exposure limits; handle as very potent corticosteroid APIs
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat or coveralls, NIOSH-approved respirator for powders
Hygiene: Wash hands before breaks and at end of work. Remove contaminated clothing and wash before reuse
Appearance: White or almost white crystalline powder
Odor: Odorless
pH: Not applicable (no significant aqueous solubility)
Melting Point: 220 – 230°C
Boiling Point: Not established; decomposes
Flash Point: Not flammable under GHS but avoid dust clouds
Solubility: Practically insoluble in water, freely soluble in methanol, acetone, chloroform
Vapor Pressure: Negligible at room temperature
Partition coefficient (log Kow): Estimated above 2 (lipophilic)
Molecular Weight: 392.87 g/mol
Stability: Stable under recommended storage conditions
Conditions to Avoid: High temperatures, humidity, exposure to light
Incompatible Materials: Strong oxidizers, acids, alkalies
Hazardous Decomposition Products: May release hazardous gases such as hydrogen chloride, hydrogen fluoride, carbon monoxide, carbon dioxide
Hazardous Polymerization: Will not occur
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Not fully established for humans; based on corticosteroid class, harmful by ingestion and inhalation in significant quantities
Skin Corrosion/Irritation: Can cause irritation and, with chronic or repeated exposure, dermal sensitization or skin thinning
Eye Damage/Irritation: May cause irritation, redness, discomfort
Respiratory Effects: Inhalation of dust may trigger respiratory tract irritation, rare risk of systemic corticosteroid side effects with heavy exposure
Chronic Toxicity: Potential systemic toxicity including immunosuppression, adrenal suppression, endocrine disruption, prolonged exposure increases risks
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogen by IARC/NTP/OSHA. Animal studies show corticosteroids interfere with reproductive function at high doses
Medical Conditions Aggravated: Pre-existing skin, respiratory, adrenal, or immune disorders
Ecotoxicity: Very toxic to aquatic life, potential for bioaccumulation
Persistence and Degradability: May persist in soil and water; breakdown in the environment is slow
Mobility in Soil: Low mobility due to low water solubility, adsorbs to soil particles
Bioaccumulation Potential: Possible due to lipophilic nature
Other Adverse Effects: Corticosteroids known to disrupt hormone cycles in some aquatic species, even at low concentrations
Waste Disposal: Incinerate at high temperature in accordance with local, state, and federal environmental regulations
Unused Products: Return to manufacturer/authorized collection agent, never dispose in household waste or wastewater
Contaminated Packaging: Treat as hazardous waste, triple rinse and puncture before incineration or disposal as regulated waste
UN Number: Not allocated for Halometasone in most transport agencies
Proper Shipping Name: Pharmaceutical chemical, not otherwise specified
Transport Hazard Class: Not regulated under ADR, IMDG, IATA for finished goods; raw powder may have restrictions based on packaging, consult supplier
Packing Group: Not assigned
Environmental Hazards: Not marine pollutant as per IMDG unless shipped in bulk
Special Precautions: Ship according to carrier guidelines for potent APIs, keep packaging intact and temperatures controlled
Labels: Pharmaceutical and chemical labeling standards per local regulations
Inventory Listings: Listed under drug substance regulations in most countries (e.g., FDA, EMA, WHO essential medicines list)
Chemical Inventory Status: May not appear on general chemical inventories due to prescription drug status
SARA/OSHA Classification: Not specifically listed; controlled substance for pharmaceutical use only
REACH/TSCA: Exempt from REACH registration and TSCA listing under “pharmaceutical products” category
Additional Requirements: Storage, handling, and waste management must follow Good Manufacturing Practice (GMP) and country-specific pharmaceutical and occupational safety laws
