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Product Name: Guggulsterone
Chemical Formula: C21H28O2
Synonyms: Guggulsterone E, Guggulsterone Z, Commiphoric acid ketosteroids
Recommended Use: Research, analytical reference, nutraceutical raw material
Supplier: Information available upon request from commercial distributor
CAS Number: 95975-55-6 (for mixture, individual isomers may hold separate numbers)
Contact Information: Emergency and technical support contact numbers provided via distributor or manufacturer
UN Number: Not assigned for this substance
Identifying Features: Off-white to pale yellow crystalline powder, mild aromatic scent
GHS Classification: Not classified as hazardous under current global harmonized system, but local handling protocols may mark as an irritant
Primary Hazards: May cause mild skin or eye irritation, ingestion in large amounts may disrupt gut function, dust may irritate respiratory tract
Pictograms: Exclamation mark (for irritant), none for acute toxicity
Acute Effects: Redness or itching after direct contact due to powder nature
Chronic Effects: Data limited, not shown to raise cancer risk, mutation, or reproductive toxicity from available literature
Sensitivity Risks: Persons with herbal allergies can experience rash or sneezing upon contact
Environmental Concerns: Not classified as dangerous to the environment under GHS assessment
Component: Guggulsterone E isomer
Concentration: 40–60% (v/v) by blend proportion, typical commercial mixture
Component: Guggulsterone Z isomer
Concentration: 40–60% (v/v) by blend proportion, typical commercial mixture
CAS Registry: 95975-55-6 for combined isomers
Impurities: Less than 2% of other ketosteroids, residues of Commiphora mukul resin trace compounds
EC Number (EINECS): 423-360-6
Molecular Weight: 312.44 g/mol
Nature of Mixture: Non-volatile blend of E and Z geometric isomers, free of solvents if properly prepared
Inhalation: Move person outside or to an area with fresh air, encourage slow breathing, monitor and seek medical advice if persistent coughing
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, rinse for at least 15 minutes if irritation develops
Eye Contact: Rinse gently with water for several minutes, try to keep eyelids open, medical attention for redness or pain lasting longer than 30 minutes
Ingestion: Rinse mouth, do not induce vomiting, drink water to dilute, seek care if large amounts consumed or gut upset severe
Note for Responders: Have product label or MSDS available for professionals in case of further medical intervention
Symptoms to Watch: Burning, sneezing, rash, vomiting, strong persistent cough
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray can suppress flames; avoid heavy water jets to prevent powder spread
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, possibly irritating organic vapors
Protective Gear for Firefighters: Full turnout gear, self-contained breathing apparatus, avoid inhalation of decomposition fumes
Explosion Risk: Powder dispersed in air might form combustible dust clouds in confined spaces
Special Precautions: Work to minimize dust, fight from upwind, prevent runoff into water drains
Further Instructions: Remove containers from exposure zone if safe
Personal Protective Gear: Gloves, safety glasses, dust mask or respirator to prevent inhalation, long sleeves
Spill Handling: Do not sweep dry, use wet towel or vacuum with HEPA filter to minimize dust cloud
Containment: Close off area to prevent further spread of powder, keep away from drains and open water
Environmental Measures: Avoid direct discharge into soil or waterways, collect spilled material for proper disposal
Decontamination: Wash contact area with soap and water after cleanup, ventilate space if needed
Waste Handling: Store residues in labeled, sealed containers for disposal according to legal requirements
Safe Handling Notes: Use with adequate ventilation, avoid generating airborne dust, never eat, drink, or smoke during handling sessions
Storage Requirements: Keep in tightly closed containers, store in a cool, dry place away from direct sunlight, heat, and incompatible substances
Incompatibilities: Strong oxidizers, acids, sources of ignition
Storage Temperature: Recommended 15–25°C (room temperature), avoid freezing
Special Instructions: Label all containers clearly, keep away from food and animal feeds
Work Practices: Use appropriate equipment to minimize spills and exposure
Stock Rotation: Follow first-in, first-out policy to reduce risk of aged, unstable product at back of shelf
Engineering Controls: Local exhaust ventilation, use dust extraction arms at weighing or mixing stations
Exposure Limits: Not established by OSHA, NIOSH, or ACGIH; treat as nuisance dust (total inhalable dust: 10 mg/m³, respirable dust: 3 mg/m³)
Personal Protection: Gloves (nitrile or latex), goggles or protective glasses, N95 or P100 dust respirator for bulk handling
Hygiene: Wash hands after use, avoid touching face, remove and wash contaminated clothing before reuse
Environmental Controls: Do not allow significant dust to accumulate near ventilation intakes or open doors
Other Protection Measures: Eye wash stations and emergency showers available in work zone
Routine Monitoring: Inspect PPE for tears or wear, fit test masks before each use
Appearance: Pale yellow to off-white crystalline or powder
Odor: Faint, resinous, lightly aromatic scent
pH: Not applicable (insoluble in water)
Melting Point: 188–194°C
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water, soluble in ethanol, DMSO, acetone
Vapor Pressure: Negligible at room temperature
Evaporation Rate: Not volatile
Density: 1.1 – 1.25 g/cm³ approximate
Flash Point: Data not available, presumed high
Partition Coefficient: LogP estimated between 3.5–5.1 (hydrophobic, bioaccumulative tendency)
Autoignition Temperature: Data not available
Decomposition Temperature: Decomposes on strong heating, above 220°C
Viscosity: Solid, not applicable
Formulation Stability: Remains solid, free-flowing in dry sealed containers under ideal storage
Chemical Stability: Stable under recommended handling and storage, does not rapidly degrade at room temperature
Hazardous Reactions: No hazardous polymerization, but reacts with strong oxidizers to release heat
Conditions to Avoid: High temperature, moisture, open flame, strong acids
Materials to Avoid: Perchlorates, permanganates, strong acids or bases, oxidizing agents
Decomposition Products: Thermal breakdown can yield carbon monoxide, carbon dioxide, possible aromatic decomposition products
Long-term Stability: Slight yellowing on prolonged exposure to air and moisture due to resin oxidation, minimal mass loss if kept tightly sealed
Acute Toxicity (Oral): LD50 is not precisely known, studies in rodents suggest low acute hazard, oral doses above 2,000 mg/kg do not show lethal effect
Skin Corrosiveness: Not corrosive but can prompt mild irritation with repeated or prolonged contact
Eye Irritation: Transient eye discomfort or redness, not classified as serious eye damage
Respiratory Sensitization: Dusty handling increases sneezing, throat irritation, no reports of asthma or fatal airway effect
Chronic Exposure Risks: Limited information, no evidence for genotoxicity, teratogenicity, or carcinogenicity in existing research
Human Experience: Used for centuries in Ayurveda and traditional medicine, rare symptoms include gut upset or headache, no severe cases of poisoning described in literature
Potential Allergic Effects: Allergic skin rashes infrequent but possible in sensitive individuals exposed to natural or blended resin powder
Medical Monitoring: No routine surveillance required if used with PPE and good hygiene, but report recurring rashes or breathing difficulty
Eco-toxicity: No data showing acute risk to aquatic life at typical release levels
Persistence and Degradability: Natural steroid framework resists rapid breakdown, slowly broken down by soil microbes
Bioaccumulation: Potential moderate for aquatic species; studies limited on actual environmental accumulation
Mobility in Soil: Strong sorption to organic matter, little migration to groundwater
Other Harmful Effects: No evidence for damage at standard waste levels
Regulatory Testing: No requirements for hazard labeling under EU or US EPA rules, though local water authorities may require monitoring for bulk active substance
Best Practice: Prevent direct release into surface water or sewer systems, collect spills for permitted disposal
Product Waste: Place excess or powder residue in sealable bags or bins, avoid flushing to wastewater
Recommended Disposal: Managed incineration in permitted facility, landfill if allowed by local rules
Container Rinsate: Triple-rinse containers and destroy or send for recycling in compliance with regional and national waste management laws
Precautions: Do not mix with municipal waste, avoid spreading on land or compost piles
Environmental Officer Notification: Alert authorities if accidental release threatens sensitive environments
Recycling: Containers can be recycled after thorough cleaning if made from suitable materials (HDPE, glass)
UN Number: Not classified as regulated for road, rail, air, or sea freight
Transport Hazard Class: Not regarded as hazardous under international transport codes
Packing Group: Not required
Special Precautions: Keep inside original or robust secondary packaging, avoid stacking heavy loads
Emergency Response: Not expected to pose immediate hazard in transport incidents, but dust control and personal protection essential in case of major spillage
Label Requirements: List as research chemical or herbal extract; indicate not for direct human consumption where required by law
Labelling: Not labeled as dangerous under OSHA, EU CLP, or UN GHS systems
Chemical Inventory List: Registered in US TSCA, EU REACH, and other local inventories as a natural extract or research chemical
Occupational Safety: Handle as non-food chemical, apply local chemical hygiene standards
Food and Drug Law: Regulated as a supplement ingredient or research substance, not an approved pharmaceutical active in most regulatory systems
Environmental Compliance: No classification as marine pollutant or hazardous air pollutant
Worker Rights: Information on safe use and PPE should be plainly available as part of workplace right-to-know obligations
Other Standards: Conform to regional safe storage and transportation laws for bulk chemical powders
