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Product Name: Guaifenesin
Chemical Name: 3-(2-methoxyphenoxy)-1,2-propanediol
Synonyms: Glyceryl guaiacolate
CAS Number: 93-14-1
Molecular Formula: C10H14O4
Recommended Use: Expectorant in pharmaceutical preparations
Manufacturer/Distributor: Provided on label or procurement documentation
Emergency Contact: Refer to local poison control center or appropriate health authority
GHS Classification: Not classified as hazardous under GHS guidelines
Potential Health Effects: Overexposure by ingestion could trigger nausea, vomiting, dizziness, gastrointestinal upset, or drowsiness. Prolonged skin contact could cause mild irritation in sensitive individuals. Dust or powder may cause eye irritation.
Signal Word: None
Pictogram: None required
Precautionary Statements: Avoid contact with eyes, prolonged skin exposure, and ingestion above therapeutic doses. Wash hands after handling.
Guaifenesin: 100% by weight
Chemical Abstracts Number (CAS): 93-14-1
Impurities/Additives: Does not contain significant impurities or additives relevant to classification
Inhalation: Move affected person to fresh air. Seek medical attention if symptoms such as coughing, difficulty breathing, or irritation persist.
Skin Contact: Wash affected area thoroughly with soap and water. Remove contaminated clothing. Seek medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Get medical attention if irritation continues.
Ingestion: Rinse mouth. Do not induce vomiting unless directed by medical professional. Seek medical attention if feeling unwell or experiencing adverse effects.
Flammability: Not considered highly flammable, but organic powder could present dust explosion hazard if dispersed in air.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam. Avoid strong water jets.
Hazards from Combustion: Combustion may produce carbon dioxide, carbon monoxide, and other potentially toxic vapors.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear to minimize inhalation and skin exposure to combustion products.
Personal Precautions: Use appropriate PPE including gloves, mask, and goggles to avoid eye and respiratory exposure.
Environmental Precautions: Prevent release into sewers or waterways. Avoid creating dust.
Methods for Cleanup: Sweep up material without generating dust and place into suitable containers for disposal. Wash spill area thoroughly to remove residue.
Handling: Avoid breathing dust or vapors. Use only with adequate ventilation. Do not eat, drink, or smoke while handling.
Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area. Keep away from strong oxidizing agents and moisture. Store at room temperature. Protect from direct sunlight.
Occupational Exposure Limits: No established exposure limits for guaifenesin. Engineering controls such as local exhaust ventilation recommended where dust is generated.
Respiratory Protection: Use approved mask or respirator if exposure to powders or aerosols is possible.
Skin Protection: Wear protective gloves and lab coat or apron as needed.
Eye Protection: Safety goggles or face shield should be worn when handling powders or solutions.
Hygiene Measures: Wash hands and face thoroughly after handling, before eating, drinking, or smoking.
Appearance: White or slightly off-white crystalline powder
Odor: Odorless or faint aromatic
pH: Not applicable
Melting Point/Range: 78–82°C
Boiling Point: 215.2°C at 760 mm Hg (decomposition may occur)
Solubility: Soluble in water, alcohol, glycerol
Vapor Pressure: Data not available
Density: Approximately 1.2 g/cm3
Partition Coefficient (log Pow): 0.3
Flash Point: Not determined
Auto-Ignition Temperature: Not determined
Chemical Stability: Stable at ambient temperatures under recommended conditions
Conditions to Avoid: Avoid excessive heat, sources of ignition, and incompatible materials such as strong oxidizing agents.
Hazardous Reactions: No dangerous reactions known under normal use or storage.
Decomposition Products: Thermal decomposition can yield carbon monoxide, carbon dioxide, and other toxic vapors.
Acute Toxicity: Oral LD50 (rat): approximately 4950 mg/kg. At therapeutic doses, well-tolerated in humans, but large overdoses can trigger nausea, vomiting, diarrhea, and central nervous system depression.
Irritation: Mild irritation possible through contact with large amounts on skin or in eyes.
Sensitization: No data suggesting significant potential for skin sensitization.
Chronic Effects: No evidence for carcinogenicity, mutagenicity, or reproductive toxicity in available animal data.
Target Organs: High doses may affect the gastrointestinal and central nervous systems.
Ecotoxicity: Data limited. Guaifenesin is not classified as environmentally hazardous, but large releases could contribute to localized toxicity in aquatic environments.
Persistence and Biodegradability: Expected to be biodegradable based on structure and limited available data.
Bioaccumulation: Not expected to bioaccumulate due to low log Pow.
Mobility in Soil: Moderate mobility expected due to water solubility.
Other Adverse Effects: No other significant adverse effects known.
Waste Disposal Methods: Dispose of material in accordance with local, state, and federal laws and regulations. Incineration in a licensed facility preferred for bulk quantities.
Contaminated Packaging: Wash and recycle or dispose of packaging in compliance with official regulations.
Do Not: Release large amounts into soil or waterways.
UN Number: Not regulated as a hazardous material for transport
Proper Shipping Name: Guaifenesin
Transport Hazard Class: None
Packing Group: Not applicable
Environmental Hazards: No
Special Precautions for Users: Minimize dust generation during handling and transport.
OSHA Status: Not regulated as a hazardous chemical
TSCA: Listed
DSL/NDSL: Listed/Not listed
SARA Title III: Not subject to reporting under Sections 302, 304, or 313
California Proposition 65: Not listed
EU Regulations: Not classified as dangerous under Regulation (EC) No 1272/2008
Other Regulations: Pharmaceutical grade material subject to regulatory oversight; workplace safety and environmental release may be subject to additional local, national, or international requirements
