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Product Name: Griseofulvin
Synonyms: 7-Chloro-2,4,6-trimethoxy-6'-methylgrisan; Fulcin
CAS Number: 126-07-8
Recommended Use: Antifungal agent
Manufacturer: Standard pharmaceutical companies and chemical suppliers
Emergency Contacts: Local poison control, local fire department, chemical emergency response teams
GHS Classification: Acute toxicity (oral, category 4), Eye irritation (category 2), Carcinogenicity (category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause eye irritation, suspected of causing cancer
Precautionary Statements: Avoid breathing dust, avoid contact with eyes or skin, use personal protective equipment as required, wash thoroughly after handling, eat or drink away from work area
Potential Health Effects: Inhalation or skin exposure can cause respiratory irritation, repeated exposure may carry risk of carcinogenicity, ingestion may trigger gastrointestinal distress, headache, fatigue, or rash, may worsen symptoms for those with known hypersensitivity
Chemical Name: Griseofulvin
Common Name: Griseofulvin
Concentration: 98-100% pure (pharmaceutical grade)
Impurities and Stabilizing Additives: May include trace processing residuals, minimal stabilizer content
Molecular Formula: C17H17ClO6
Molecular Weight: 352.77 g/mol
CAS Number: 126-07-8
Inhalation: Move to fresh air, seek medical attention for ongoing symptoms such as coughing or difficulty breathing
Skin Contact: Rinse affected area with plenty of soap and water, remove contaminated clothing, medical care for persistent irritation
Eye Contact: Rinse thoroughly with running water for at least 15 minutes, seek professional care for burning, redness, or vision problems
Ingestion: Rinse mouth, do not induce vomiting, call a physician or poison control for further advice, give water if victim is alert
General: Treat based on symptoms, show this sheet to healthcare professionals
Suitable Extinguishing Media: Water spray, foam, dry chemical powder, carbon dioxide
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, chlorine-containing compounds
Special Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus
Fire/Explosion Hazards: Fine dust may form explosive mixtures with air, thermal decomposition can create hazardous fumes
Precautions: Evacuate area, use spray to cool surfaces, control runoff, avoid inhaling smoke or fumes
Personal Precautions: Wear chemical-resistant gloves, protective goggles, dust mask or respirator, prevent dust generation, ventilate area
Environmental Precautions: Prevent entry to drains, waterways, and soil, report significant spillage to local authorities
Methods For Clean Up: Sweep or scoop material into labeled waste containers, minimize dust, wipe down contaminated surfaces with damp paper towels, dispose of clean-up materials as hazardous waste, wash hands thoroughly after exposure
Spill Response: Escalate to emergency personnel for large volumes, restrict unprotected access, ensure appropriate decontamination of area and tools
Safe Handling: Work in well-ventilated areas, avoid dust generation, do not eat, drink, or smoke while handling, use proper PPE at all times, do not mix with incompatible chemicals
Storage Requirements: Secure container in a cool, dry, well-ventilated place, keep container tightly closed, protect from light and moisture, segregate from strong oxidizing agents or acids
Storage Materials: Use original packaging or chemically compatible containers, avoid metal and reactive surfaces
Occupational Exposure Limits: No OSHA, ACGIH, NIOSH exposure limits established for griseofulvin, minimize dust to lowest feasible level
Engineering Controls: Utilize local exhaust or good general ventilation, sealed processes preferred for bulk work
Personal Protective Equipment (PPE): Safety glasses or goggles, chemical-resistant gloves, lab coat or protective clothing, NIOSH-approved dust respirator in dusty settings
Hygiene Practices: Remove clothing that may have become contaminated, wash hands and face after handling, keep contaminated garments away from clean areas
Appearance: White to pale cream-colored crystalline powder
Odor: Slight, characteristic
Odor Threshold: Not available
pH: Not applicable (insoluble in water)
Melting Point/Range: 219–223°C
Boiling Point: Not available
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Combustible as a fine dust
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: 1.4–1.5 (water = 1)
Solubility: Insoluble in water, freely soluble in acetone, chloroform, and slightly soluble in alcohols
Partition Coefficient (log Kow): 2.18
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 250°C
Viscosity: Not applicable
Stability: Stable at room temperature in closed containers
Reactivity: Not reactive under recommended conditions, does not polymerize
Chemical Incompatibilities: Strong oxidizing agents, acids, alkalis
Hazardous Decomposition Products: Emits carbon oxides, chlorine gas under fire conditions
Hazardous Polymerization: Will not occur under normal use
Acute Toxicity: Oral median lethal dose (LD50) in rats: approximately 6,000 mg/kg
Skin and Eye Irritation: May cause mild irritation on contact
Sensitization: May trigger allergic reaction in sensitized individuals
Chronic Effects: Prolonged exposure linked to liver enzyme induction in animals
Carcinogenicity: IARC: Group 2B (“possibly carcinogenic to humans”)
Mutagenicity: Test results mixed; some evidence from animal assays
Reproductive Toxicity: Mixed animal study evidence, not considered a major risk at therapeutic doses
Target Organs: Liver, possible impacts on blood formation
Summary of Clinical Symptoms: Headache, nausea, rash, photosensitivity, rarely severe allergic response
Pre-existing Conditions: Risk increases with known hypersensitivity, history of liver disease
Ecotoxicity: Low acute aquatic toxicity, chronic effects in aquatic life not fully determined
Persistence: Environmental degradation progresses slowly, resistant to rapid breakdown
Bioaccumulation Potential: Moderate potential due to chemical stability
Mobility in Soil: Binds to soils due to poor solubility, little leaching expected
Other Adverse Effects: Further research required on longer-term environmental persistence and bioaccumulation
Waste Handling: Treat as hazardous chemical waste, do not allow to contaminate soil or surface water, avoid release to environment
Disposal Methods: Transfer waste to licensed chemical disposal facility, follow all local, regional, and national regulations
Packaging Disposal: Decontaminate containers where possible, puncture and render unusable to prevent misuse, follow labeling requirements for all residues
Unused Product: Return to supplier or reputable hazardous waste service for incineration or secure landfill
UN Number: Not classified as dangerous under UN transport regulations
Transport Hazard Class: Not regulated as a hazardous material
Packing Group: Not assigned
Proper Shipping Name: Griseofulvin or pharmaceutical product, not hazardous
Environmental Hazards: Avoid release during major spills
Special Precautions for User: Maintain containers sealed and protected from rough handling, minimize dust during transportation, keep away from food and feedstuffs
OSHA: Not listed as hazardous under OSHA HCS
TSCA: Listed in the United States Toxic Substances Control Act (TSCA) Inventory
WHMIS (Canada): Uncontrolled product according to WHMIS classification
REACH Status (EU): Registered or exempt substance, not classified as hazardous
California Proposition 65: Not listed
SARA Title III: Not subject to reporting under SARA Title III Sections 302, 304, 313
Inventory Status: Australia (AICS), Korea (KECI), Japan (ENCS), China (IECSC) all report substance present in inventories
