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Product Name: Granisetron Hydrochloride
Chemical Formula: C18H24N4O•HCl
Trade Name: Granisetron HCl
Common Uses: Antiemetic for chemotherapy and radiotherapy patients
CAS Number: 107007-99-8
Manufacturer Address: Supplier’s contact details required on packaging
Emergency Phone: National Poison Control or local regulatory body
Hazard Classification: Classified as irritant, not considered a carcinogen or mutagen under the US OSHA Hazard Communication Standard
Signal Word: Warning
Pictogram: Exclamation mark
Potential Health Effects: May cause mild respiratory or skin irritation, contact with eyes can lead to redness or itching, harmful if swallowed in large quantities
Environment Risk: Not classified as environmentally hazardous under typical usage; keep out of waterways
Chemical Name: Granisetron Hydrochloride
Purity: >98%
Inactive Components: None known
Impurities: Pharmaceutical grades typically limit related substances to less than 0.5%
Inhalation: Move to fresh air, seek medical advice if coughing or discomfort persists
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, consult physician for irritation
Eye Contact: Rinse carefully with running water for several minutes keeping eyelids open, consult doctor if symptoms continue
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical attention
General Advice: Always have access to medical care, show the safety data sheet to the provider
Suitable Extinguishing Media: Dry powder, carbon dioxide, foam or water spray
Unsuitable Media: Direct water jet, as it may spread the material
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides during combustion
Protective Equipment: Self-contained breathing apparatus and full protective gear in a fire
Special Procedures: Avoid inhaling smoke or vapors, use water spray to cool storage containers
Personal Precautions: Wear gloves, protective goggles, respirator for dust
Environmental Precautions: Prevent product from entering drains or surface water
Methods for Clean Up: Use inert absorbent, sweep up, place in a secure labeled container for disposal, ventilate area
Decontamination: Wash spill area with water and detergent
Handling: Wear proper PPE, avoid contact with skin, eyes, and clothing, avoid inhalation
Hygiene: Wash hands after handling, keep work area clean, do not eat, drink, or smoke in processing area
Storage Conditions: Store in well-ventilated, dry, cool area
Storage Incompatibility: Keep away from strong oxidizing agents, acids, and moisture
Packing Materials: Airtight, light-resistant containers recommended
Occupational Exposure Limits: No established OSHA or ACGIH limits; practice good industrial hygiene
Engineering Controls: Work under local exhaust or general ventilation
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat or disposable suit
Respiratory Protection: Use P2 dust mask in case of dust formation
Environmental Controls: Use procedures to minimize environmental release
Appearance: White or almost white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
Melting Point: 290°C (dec.)
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water and methanol, practically insoluble in dichloromethane
pH (1% aqueous): 4.0–6.0
Vapor Pressure: Not applicable
Density: 1.22 g/cm³
Chemical Stability: Stable under normal handling and storage conditions
Possible Hazardous Reactions: No hazardous polymerization anticipated
Incompatibilities: Oxidizing agents, strong acids, strong bases
Conditions to Avoid: Excess moisture, prolonged exposure to heat or light
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen chloride
Acute Toxicity: LD50 (oral, rat) >5000 mg/kg (low ingestion toxicity)
Skin Irritation: May cause mild irritation upon direct exposure
Eye Irritation: Redness or discomfort can occur with direct contact
Respiratory Sensitization: Chronic inhalation of dust may cause respiratory tract irritation
Mutagenicity: Negative for mutagenicity in several in vitro tests
Carcinogenicity: No evidence in animal studies, not classified by IARC or NTP
Reproductive Toxicity: No significant risk at therapeutic doses, animal reproductive effects at very high doses
Aquatic Toxicity: Limited data; not expected to bioaccumulate or persist in the environment
Soil Mobility: Likely low mobility due to solubility and pharmaceutical use pattern
Biodegradability: Expected to degrade over time under environmental conditions
Environmental Concerns: Avoid release to waterways, encourage treatment at pharmaceutical facilities
Waste Disposal Methods: Dispose in accordance with local, regional, and national regulations; avoid direct release to environment
Incineration: Recommended for significant quantities in an approved facility
Container Disposal: Decontaminate empty containers before disposal or recycling, follow hazardous waste protocols
Special Precautions: Do not mix with general waste or pour into drains
UN Number: Not classified as hazardous for transport
Transport Hazard Class: Not regulated
Packing Group: No packing group assigned
Proper Shipping Name: Granisetron Hydrochloride, pharmaceutical product
Special Precautions: Avoid damage to packaging, transport in accordance with local and national regulations
Safety, Health and Environmental Regulations: Subject to pharmaceutical regulations by FDA, EMA, and comparable agencies
Inventory Listing: Listed under US TSCA or pharmaceutical exemptions, check local regulatory status
Label Requirements: Must display hazard identification and supplier contact information
REACH Status (EU): Pharmaceutical product exemptions apply; consult manufacturer for details
Worker Protection: Ensure adherence to occupational health and safety regulations at all stages of handling
