© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Glycerol Formal
Chemical Family: Organic solvent, polyol ether
Synonyms: 1,3-dioxolan-4-methanol; Formal glycerol; Glycerin Formal
CAS Number: 4740-78-7
Recommended Use: Medicinal carrier, solvent in pharmaceutical preparations
Manufacturer/Supplier: Information provided on product packaging or manufacturer’s documentation
Emergency Contact: Refer to corporate safety or local poison control authorities for emergency numbers and procedures plus the location’s emergency protocol cards.
GHS Classification: Causes mild irritation to skin and eyes, can create respiratory discomfort if inhaled in large volumes, typically low acute toxicity
Label Elements: Signal word “Warning”; precautionary pictograms (exclamation mark)
Hazard Statements: May cause slight skin and eye irritation; may cause mild respiratory irritation; not considered highly hazardous
Precautionary Statements: Avoid contact with eyes, prolonged skin contact or excessive inhalation; utilize sensible protective equipment
Pictograms and Codes: Exclamation mark symbol, hazard statement code: H316, H320, H335
Physical Hazards: Not flammable under standard circumstances; no significant reactive hazard
Environmental Hazards: Low environmental impact under normal use, though large releases can contribute to aquatic toxicity
Chemical Name: Glycerol Formal
Chemical Formula: C4H8O3
Concentration: 98-100% (may contain trace water and byproducts)
Impurities or Stabilizing Additives: None typically expected in pharmaceutical grades
Molecular Weight: 104.1 g/mol
Inhalation: Remove exposed person to fresh air; monitor for lingering symptoms such as headache or coughing.
Skin Contact: Rinse gently with soap and water, remove contaminated clothing; seek further care if irritation develops.
Eye Contact: Rinse immediately with clean water for at least 15 minutes; do not rub eyes; get prompt medical attention if discomfort continues.
Ingestion: Rinse mouth with water, seek medical assessment if large quantity ingested; avoid forced vomiting.
Notes to Physician: Treat symptomatically; monitor for secondary complications such as respiratory or allergic reaction.
Suitable Extinguishing Media: Water spray, foam, CO2, dry chemical powder; choose according to surrounding fire materials.
Specific Hazards: Burning can yield carbon monoxide, carbon dioxide and minor formaldehyde vapors; containers exposed to fire may rupture.
Special Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus are required.
Firefighting Instructions: Cool fire-exposed containers with water to minimize risk of rupturing.
Flash Point: Greater than 140°C (closed cup); not classified as highly flammable.
Personal Precautions: Use gloves, eye protection, face shield or goggles as necessary; avoid direct contact with product.
Environmental Precautions: Prevent run-off into storm drains, surface waters, or soil; alert authorities if large spill poses local environmental risk.
Methods for Clean Up: Absorb spillage with non-combustible materials like sand, vermiculite or specialized absorbents; place residue in suitable chemical waste container; wash affected area thoroughly after removal, ventilate space.
Handling: Ensure adequate ventilation, avoid skin and eye contact; implement workplace hygiene and use proper PPE.
Storage Conditions: Keep in cool, dry, well-ventilated area; protect from excessive heat and direct sunlight; store in tightly sealed containers made from compatible materials.
Incompatible Products: Strong acids, oxidizing agents or strong bases can react undesirably.
Special Storage Guidance: Label containers accurately, keep away from foodstuffs and incompatible substances; ensure secondary containment to prevent accidental spillage.
Occupational Exposure Limits: No established workplace limits, but observe good practice with general chemical handling.
Engineering Controls: Use general and local exhaust ventilation; avoid accumulation of vapor or mist.
Personal Protection Equipment: Gloves (nitrile or latex), safety goggles, lab coats or apron; use face shield for high splash risk; do not eat, drink or smoke during handling.
Respiratory Protection: Use NIOSH/MSHA approved respirator if ventilation insufficient or exposure may exceed recommendations.
Environmental Protection: Apply measures to contain potential drips and runoff.
Appearance: Clear, colourless to pale yellow liquid
Odor: Mild, slightly sweet
pH: Neutral, typically between 6-7 (in aqueous solution)
Melting Point / Freezing Point: Near −30°C
Boiling Point / Boiling Range: Approaches 195°C
Flash Point: Above 140°C (closed cup)
Evaporation Rate: Very slow
Flammability: Low; supports combustion at high temperatures
Vapor Pressure: Negligible at room temperature
Solubility: Miscible with water and many organic solvents
Viscosity: Moderate, less viscous than glycerol
Partition Coefficient: Not significantly bioaccumulative
Chemical Stability: Stable under recommended conditions, no pronounced hazards under temperature or pressure extremes seen in laboratory settings.
Hazardous Reactions: May react with strong acids, strong oxidizers or strong bases to yield irritating vapors or byproducts.
Decomposition Products: Major breakdown can release formaldehyde, carbon monoxide, carbon dioxide.
Conditions to Avoid: Keep away from open flame, excessive heat, and incompatible chemicals.
Likely Routes of Exposure: Inhalation, skin and eye contact, incidental ingestion
Acute Toxicity Data: Very low oral and inhalational toxicity in animal studies – LD50 (oral, rat): >2000 mg/kg
Chronic Effects: Prolonged skin or eye contact may cause mild irritation; not expected to be carcinogenic, teratogenic, or mutagenic
Potential Symptoms: Redness, dryness or irritation at contact points, mild headache or dizziness from vapor in closed space
Sensitization: Not commonly reported
Other Health Effects: No known impact on reproductive systems or major organs at proper handling levels
Ecotoxicity: Not classified as hazardous for aquatic life; acute aquatic toxicity low but avoid deliberate release to watercourses
Persistence and Degradability: Biodegradable under typical environmental conditions
Bioaccumulative Potential: Expected to have low bioaccumulation
Mobility in Soil: High mobility; miscible with water, can move through soil layers if spilled in large volume
Other Adverse Effects: Persistent overuse may alter water chemistry and oxygen demand in localized environments
Waste Disposal Methods: Dispose via licensed contractor according to local, regional, and federal guidelines; avoid pouring into drains or waterways
Container Disposal: Triple rinse containers, remove labels, puncture unusable containers before recycling or disposal as chemical waste
Additional Disposal Info: Solutions and residues must not enter surface or ground water; consider the material’s complete lifecycle impact
UN Number: Not classified as hazardous for transport under UN Recommendations
Proper Shipping Name: Glycerol Formal
Transport Hazard Class: Not regulated as dangerous goods
Packaging Group: None required under typical guidelines
Special Precautions: Use secure, leak-proof containers; prevent loading with incompatible substances such as strong oxidizers
Environmental Hazards: None under routine handling and shipment
Safety, Health and Environmental Regulations: Listed under relevant international and regional inventories (e.g., US TSCA, EU REACH, Canada DSL)
OSHA & EU Regulation: No specific workplace exposure limits, follows general industrial safety hygiene protocols
Other Federal and Local Laws: Product labeling and shipping adhere to product-specific pharmaceutical or chemical regulations
Additional Classification: Not subject to stringent special risk phrases or precautionary labeling beyond basic chemical safety requirements
