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Product Name: Gcle; 7-Phenylacetamido-3-Chloromethyl-4-Cephalosporanic Acid P-Methoxybenzyl Ester
Chemical Family: Cephalosporin derivative
Synonyms: Not widely established
Recommended Uses: Pharmaceutical intermediate
Supplier: Refer to label or manufacturer for updated details
Emergency Contact: Consult relevant company safety officer or national poison control
Classification: Skin and eye irritant; possible respiratory sensitizer; no major flammability risk
Signal Word: Warning
Hazard Statements: May cause allergic skin or respiratory reaction; causes irritation to eyes, skin, and mucous membranes
Pictogram: Exclamation mark
Precautionary Statements: Avoid inhalation or contact with skin and eyes; use proper protective equipment
Chronic Exposure Risks: No full studies available on long-term effects in non-lab animals or humans
Other Risks: May aggravate existing respiratory conditions; accidental ingestion could provoke gastrointestinal upset and related reactions
Main Ingredient: Gcle; 7-Phenylacetamido-3-Chloromethyl-4-Cephalosporanic Acid P-Methoxybenzyl Ester
Purity: Above 98% in pharmaceutical grade lots
Impurities: May contain trace organic solvents, residual reagents (typically less than 2%)
CAS Number: Refer to product specification sheet or regulatory documentation
Other Components: No significant non-active ingredients; not formulated with excipients
Hazardous Components: Primary ingredient considered hazardous based on cephalosporin core and chloroalkyl side group
Exposure Limits: Not established, use as per laboratory chemical policies
Inhalation: Remove to fresh air immediately; monitor for respiratory distress; seek medical attention if symptoms persist
Skin Contact: Wash area thoroughly with soap and water; remove contaminated clothing; consult physician for persistent reaction
Eye Contact: Rinse with gentle, running water for at least 15 minutes, holding eyelids apart; seek medical attention for irritation or visual changes
Ingestion: Seek medical help right away; rinse mouth with water but do not induce vomiting unless directed by medical personnel
Note for Physician: Treat symptomatically, watch for allergic or anaphylactic responses
Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray; avoid direct water jet
Fire Hazards: No strongly flammable solvents; thermal breakdown can release toxic fumes – carbon monoxide, nitrogen oxides, hydrochloric acid, sulfur oxides
Protective Equipment: Use self-contained breathing apparatus and full protective gear in fire area
Special Procedures: Avoid inhalation of combustion gases; move undamaged containers away from immediate fire zone if safe
Combustion Products: Decompose to yield phenylacetamide derivatives, acid gases, and halogen-bearing smoke
Personal Precautions: Use respiratory protection, gloves, safety goggles; keep unprotected personnel away
Environmental Precautions: Contain spill to prevent entry into drains or watercourses
Clean-Up Methods: Pick up solid product with an appropriate tool; sweep up carefully; avoid dust generation; ventilate area
Decontamination: Wash area with detergent and excess water; dispose materials as chemical waste
Notification: Inform supervisor and follow facility spill procedures
Handling Practices: Use in well-ventilated area; minimize dust; do not breathe dust or let contact with skin, eyes, or clothing
Conditions to Avoid: High humidity, temperature extremes, ignition sources
Storage Requirements: Tight container in cool, dry, dark place; moisture-absorbing desiccant recommended
Special Equipment: Use scoop or spatula made of non-reactive material; avoid metal tools when possible
Incompatible Materials: Strong oxidizers, acids, bases, reducing agents
Engineering Controls: Chemical fume hood, local exhaust ventilation to minimize airborne particles
Personal Protection – Eye: Chemical splash goggles or face shield
Personal Protection – Skin: Nitrile or neoprene gloves, lab coat, closed-toe shoes
Personal Protection – Respiratory: NIOSH-approved dust mask or respirator, especially for bulk handling
Work Hygiene: Wash hands after handling; do not eat, drink, or smoke near product
Exposure Limits: No established occupational limits; treat as sensitizer and irritant
Monitoring: Environmental and personal monitoring recommended in large-scale production or compounding settings
Appearance: Fine crystalline powder; color ranges from off-white to pale yellow
Odor: Mild, medicinal or chemical aroma
pH (of solution): Not established, likely acidic to neutral
Melting Point: Approximately 170–180 °C (decomposition may occur at this temperature)
Boiling Point: Not applicable, may decompose before boiling
Solubility: Slightly soluble in water; soluble in organic solvents such as acetone, methanol, dichloromethane
Vapor Pressure: Negligible at room temperature
Density: Not thoroughly characterized
Stability in Solution: Stable in dry form; hydrolyzes in moisture or alkaline conditions
Chemical Stability: Stable under recommended storage; moisture and heat accelerate decomposition
Polymerization: Will not occur under normal laboratory or industrial conditions
Hazardous Decomposition Products: Chloroacetyl gases, phenylacetamide fragments, CO2, sulfur dioxide, HCl
Incompatible Materials: Strong oxidizing or reducing agents, acids, bases (may hydrolyze or degrade compound)
Conditions to Avoid: High temperature, light, excessive moisture
Routes of Exposure: Inhalation, dermal, ocular, ingestion possible in laboratory or production settings
Acute Toxicity: Low oral and dermal toxicity indicated in animal studies; specific LD50 data sparse
Chronic Toxicity: Prolonged exposure to cephalosporins linked to sensitization, rarely severe allergic response
Symptoms: Coughing, sneezing, red or itchy skin, possible anaphylaxis in sensitized individuals
Medical Conditions Aggravated: Asthma, eczema, history of penicillin or cephalosporin allergy
Carcinogenicity: No conclusive human data; not listed as human carcinogen by NTP, IARC, or OSHA
Other Effects: Repeated exposure may cause local skin or respiratory irritation
Aquatic Toxicity: Not fully assessed; similar compounds can be toxic to aquatic microorganisms and invertebrates
Persistence and Degradability: Cephalosporin derivatives degrade slowly in environment; potential for bioaccumulation low
Mobility: Limited mobility in soil due to low water solubility
Other Ecological Risks: Avoid release to waterways or soil to prevent microbial culture disruption
Bioaccumulation Potential: Expected to be low
Disposal Impact: Improper disposal could impact wastewater treatment plant microflora
Waste Handling: Treat as hazardous chemical waste; collect in clearly labeled container
Disposal Method: Incinerate in approved facility or dispose by licensed chemical waste contractor
Container Handling: Triple-rinse and destroy before landfill disposal; follow site-specific chemical hygiene plan
Notification Requirements: Adhere to local, national, and international guidelines for pharmaceutical waste
Precautions: Do not dump into sewers or natural waterways; avoid contact with municipal waste streams
UN Number: Not classified under a specific shipping UN number (consult shipping agent for updates)
Class: Not regulated under most jurisdictions for small quantities, but classified as hazardous for bulk
Packing Group: None assigned for laboratory-scale amounts
Proper Shipping Name: Chemical, n.o.s. (not otherwise specified) or as required by carrier
Special Precautions: Seal container; avoid breakage or spillage during transport
Transport Labels: Hazardous chemical, possible irritant
Environmental Risk: Avoid spillage and runoff to environment in transit
TSCA: Not listed for general public use, likely restricted to research, development, or manufacturing under specific controls
REACH: Status subject to annual review, listed for pharmaceutical research only
OSHA Hazard: Hazardous substance; treat under laboratory standard or equivalent industry code
SARA/Title III: Not specifically listed as reportable, but may be included in broad pharmaceutical reporting
WHMIS: Controlled product; D2B (Toxic Material Causing Other Toxic Effects)
Other National Regulations: Restrictions or workplace controls in some jurisdictions; consult local chemical handling laws
Inventory Listings: Chemical falling under prescription pharmaceutical or intermediate registries; not open to consumer uses
