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Product Name: Gastrodin.
Chemical Name: 4-Hydroxybenzyl β-D-glucopyranoside.
Synonyms: Gastrodia elata glucoside.
CAS Number: 62499-27-8.
Molecular Formula: C13H18O7.
Molecular Weight: 286.28 g/mol.
Common Uses: Found in herbal supplements, research labs, traditional medicine formulations targeting cognitive health and neuroprotection.
Main hazards: Gastrodin is considered to have low acute toxicity. Inhalation of powder or dust can irritate respiratory passages. Eye or skin contact may cause mild irritation, especially for sensitive individuals. No significant evidence links Gastrodin to carcinogenic, mutagenic or reproductive harm under common lab use, but dust formation and inhalation should still be avoided.
Pictogram or Signal Word: Not classified under major hazard categories by the GHS or OSHA, but handling precautions are warranted.
Chronic effects: Data on long-term exposure remains limited. Sensitization through repeated exposure has not been reported in literature to date.
Active Ingredient: Gastrodin, typically greater than 98% purity for research-grade samples.
Impurities: Possible trace levels of related glucosides if extracted from plant material; synthetic sources tend to yield high-purity product.
Form: Usually a fine, off-white crystalline powder.
Inhalation: Move affected person to fresh air. Support breathing if symptoms like coughing or sneezing develop.
Eye Contact: Rinse eyes with water for several minutes. Remove contact lenses if present. Seek medical attention for prolonged redness or discomfort.
Skin Contact: Wash with plenty of soap and water. Remove contaminated clothing.
Ingestion: Rinse mouth with water. Drink water to dilute. Medical advice may be prudent if significant quantities ingested or symptoms develop.
Suitable extinguishing media: Water spray, dry chemical, foam, or CO2 can knock down fires involving Gastrodin, since it is an organic solid.
Hazardous combustion products: Thermal decomposition could yield carbon oxides such as carbon monoxide and carbon dioxide.
Fire-fighting instructions: Use self-contained breathing apparatus for enclosed spaces. Cool nearby containers with water if exposed to flames.
Special risks: Gastrodin itself is not known to present unusual fire or explosion risks, though dust clouds have the potential for combustion in certain conditions. Avoid accumulation of airborne dust and ignition sources.
Personal precautions: Wear gloves, eye protection and dust mask to avoid direct contact and inhalation. Evacuate area if large amounts spilled.
Cleanup methods: Sweep up carefully and transfer to a sealed container. Minimize dust and ventilate area well.
Environmental precautions: Prevent spillage from entering drains, sewers or natural waterways. Absorb any liquid residues with inert material such as vermiculite.
Handling: Handle with clean gloves and eye protection; minimize airborne dust. Work in a fume hood or well-ventilated area if possible.
Storage: Store in cool, dry place, ideally in a tightly sealed container away from humidity, sunlight, and heat sources. Avoid storing near oxidative chemicals or strong acids, which may degrade the compound. Keep out of reach of children and unauthorized personnel.
Engineering controls: Use local exhaust or laboratory fume hood to keep airborne concentrations low.
Personal protective equipment: Wear lab coat, protective gloves, and standard safety goggles to prevent skin and eye contamination. For occupational handling of quantities, a dust mask or respirator is sensible to block inhalation.
Hygiene measures: Wash hands thoroughly after handling. Remove and wash contaminated clothing before reuse. Do not eat or drink in work areas where Gastrodin is present.
Appearance: Off-white to pale yellow crystalline powder.
Odor: Odorless.
Melting Point: Ranges around 132–134 °C.
Solubility: Readily soluble in water, moderately soluble in ethanol.
pH: Slightly acidic in aqueous solution.
Boiling Point: Not applicable – decomposition expected before boiling.
Partition Coefficient (Log P): Data limited, but due to glucoside nature, low lipid solubility expected.
Chemical stability: Stable under recommended storage conditions. Gastrodin can slowly degrade under exposure to strong oxidizing agents or direct sunlight over extended periods.
Reactive hazards: Incompatible with strong oxidizers and strong acids which may trigger decomposition or hydrolysis.
Polymerization: No dangerous polymerization reported.
Decomposition: Heating to decomposition releases hazardous vapors, mainly carbon oxides.
Acute Toxicity: Animal studies on Gastrodin suggest low toxicity with LD50 values for oral administration far above typical exposure levels in humans. No deaths or severe toxicity in animal models in moderate doses.
Irritation: Mild skin and eye irritant by direct contact in sensitive individuals.
Chronic toxicity: No reported evidence of carcinogenic effects, reproductive toxicity or hereditary genetic effects even with repeated exposures in animal studies.
Other health effects: Rare hypersensitivity allergic responses have not been documented. Gastrodin is used as an active ingredient in traditional herbal medicine, typically in microgram to milligram dosages.
Ecotoxicity: No significant aquatic or terrestrial toxicity data reported in scientific literature. As a natural plant extract and carbohydrate derivative, Gastrodin is unlikely to bioaccumulate or persist in the environment.
Mobility in soil: Water solubility suggests moderate mobility, but environmental levels after typical use expected to be negligible.
Persistence and degradability: Readily biodegradable, especially in the presence of microorganisms.
Other adverse effects: No data linking Gastrodin to environmental hazards or ecosystem disruption.
Waste disposal: Dispose of unused Gastrodin in accordance with local and national regulations as non-hazardous laboratory waste. Small quantities should be diluted and rinsed with copious water, followed by disposal in designated chemical waste bins.
Packaging disposal: Empty containers and packaging should be triple-rinsed before recycling or discarding, in line with the facility's chemical waste disposal protocols. Avoid release to surface water or municipal sewers.
UN Number: Not assigned since Gastrodin is not classified as hazardous for transportation under IATA, IMDG or ADR.
Transport risk: No significant hazards in normal commercial package and transit conditions. Avoid exposure to moisture during storage and shipment to maintain product quality.
Shipping Labels: Not required for non-hazardous chemical; label packaging with identity and quantity.
Classification: Not listed as a hazardous substance under major international or national chemical regulatory frameworks.
SARA Title III Status: Not regulated.
California Proposition 65: Not listed.
Other international inventory status: Not listed as a controlled or restricted substance.
Workplace requirements: Basic personal and workplace safety standards apply as with most non-hazardous research chemicals.
