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Product Name: Furazolidone
Chemical Family: Nitrofuran derivative
Synonyms: FZD; Nitrofurazolidone; 3-[(5-nitro-2-furanyl)methyleneamino]-2-oxazolidinone
CAS Number: 67-45-8
Recommended Use: Veterinary antimicrobial, research chemical
Manufacturer: [Manufacturer details to be filled based on purchase point]
Emergency Contact: Refer to local Poison Control Center or medical emergency hotline
GHS Classification: Acute toxicity (oral, dermal, inhalation) – Category 3, Eye irritation – Category 2A, Skin irritation – Category 2, Carcinogenicity – Category 2
Signal Word: Danger
Hazard Statements: Toxic if swallowed; causes skin and eye irritation; suspected of causing cancer; may cause respiratory irritation; may cause allergic skin reaction
Precautionary Statements: Avoid breathing dust or fumes; wash skin thoroughly after handling; wear protective gloves, clothing, eye, and face protection; do not eat, drink, or smoke during use; avoid release to environment
Potential Health Effects: Short-term exposure can lead to nausea, headache, dizziness, and allergic reactions; long-term or repeated exposure may cause liver toxicity, anemia, or potential carcinogenic effects
Chemical Name: Furazolidone
CAS Number: 67-45-8
Percentage: 98-100% (pure), synthesized for industrial or pharmaceutical supply
Impurities: Trace solvents or byproducts from synthesis can include organic solvents below 1% by weight
Inhalation: Remove person to fresh air, keep at rest in a position comfortable for breathing, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with soap and water for at least 15 minutes, consult a physician for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical attention
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, seek immediate medical care
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam
Unsuitable Extinguishing Media: Direct jet of water can spread powder and cause contamination
Specific Hazards: Fire may produce hazardous fumes such as nitrogen oxides, carbon oxides, and other toxic gases
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, protective clothing, and gloves
Special Procedures: Move undamaged containers from fire area if safe; use water spray to cool exposed surfaces
Personal Precautions: Keep unnecessary personnel away, wear appropriate personal protective equipment, ventilate area
Spill Cleanup Methods: Scoop up spilled solid and place in labeled waste container; avoid creating dust; clean area with damp cloth or mop
Environmental Precautions: Avoid entering drains, sewers, or waterways
Disposal: Follow local environmental regulations for chemical disposal, send waste to approved hazardous waste facility
Handling: Handle only in well-ventilated areas, avoid breathing dust or vapor, use protective equipment
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing, keep food and drink away from work area
Storage Conditions: Store in tightly closed container in a cool, dry, well-ventilated place away from light and incompatible substances
Incompatibilities: Strong oxidizing agents, acids, bases
Special Sensitivities: Sensitive to heat, light, and moisture
Occupational Exposure Limits: No established OSHA or ACGIH limits for Furazolidone
Engineering Controls: Local exhaust recommended, eye wash and safety shower should be available
Personal Protective Equipment: Respirator for dust/fume, chemical splash goggles, protective gloves (preferably nitrile), laboratory coat or apron
Workplace Practices: Prevent formation of vapor or dust, keep away from foodstuff and beverages
Appearance: Yellow to brown crystalline powder
Odor: Weak characteristic odor
Odor Threshold: Not determined
pH: Not applicable (solid form)
Melting Point: 254–256°C (decomposes)
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in dimethyl sulfoxide, ethanol, and acetone
Partition Coefficient (log Pow): 0.4–0.8 (estimated)
Vapor Pressure: Negligible at ambient temperature
Relative Density: 1.6–1.7 g/cm³
Flash Point: Not available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Above 254 °C
Explosive Properties: Not explosive
Oxidizing Properties: Not oxidizing
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not considered reactive under normal laboratory handling
Hazardous Reactions: Contact with strong oxidizers can cause violent reaction
Conditions to Avoid: Exposure to heat, light, and moisture
Incompatible Materials: Strong acids, bases, and oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, and toxic fume compounds under fire conditions
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Oral LD50 (rat): 150–400 mg/kg
Skin Corrosion/Irritation: May cause moderate-to-severe skin irritation
Serious Eye Damage/Irritation: Causes irritation
Respiratory Sensitization: Possible respiratory tract irritation
Skin Sensitization: May trigger allergic skin reactions
Germ Cell Mutagenicity: Evidence of mutagenic effects in laboratory studies
Carcinogenicity: Classified as potential carcinogen based on animal studies; not listed by NTP, IARC, or OSHA
Reproductive Toxicity: Adverse effects shown in animal fertility studies
STOT (Single and Repeated Exposure): Possible effects on liver, blood, and nervous system
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Limited biodegradability in soil/water
Bioaccumulative Potential: Low to moderate potential for bioaccumulation in aquatic organisms
Mobility: Expected to have low mobility in soil due to low water solubility
Other Adverse Effects: Strong environmental monitoring advised if released; antibiotic action can disrupt microbial ecosystems
Waste Disposal Methods: Dispose of as hazardous waste according to local, state, and federal regulations
Container Handling: Triple rinse containers prior to disposal, incinerate or send to authorized hazardous waste facility
Special Precautions: Do not discharge to surface water, sewer, or ground
UN Number: Not classified as dangerous good under most ADR, IMDG, IATA regulations for transport
Proper Shipping Name: Furazolidone
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not marine pollutant under IMDG but should minimize environmental release
Special Transport Precautions: Keep container tightly closed, limited exposure to moisture, temperature extremes and strong sunlight
OSHA Status: Not specifically regulated under OSHA hazardous substances
SARA Title III: Not listed as reportable quantity or extremely hazardous substance
TSCA Status: Listed in the Toxic Substances Control Act Inventory
REACH Status: Subject to regulatory restrictions under EU REACH
California Proposition 65: Not listed
Other Local/International Regulations: Use or sale for food-producing animals restricted or banned in several countries; EPA and FDA monitor use closely because of potential human health risks
