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Product Name: Folic Acid
Chemical Name: Pteroylglutamic Acid
Synonyms: Vitamin B9, Folacin
CAS Number: 59-30-3
EC Number: 200-419-0
Recommended Use: Nutritional supplement, pharmaceutical manufacture
Supplier Information: Name, address, and telephone number of the supplier or manufacturer responsible for the chemical
Emergency Contact: Contact details for 24-hour emergency assistance
GHS Classification: Not classified as hazardous under current GHS criteria
Physical Hazards: Dust may form explosive mixtures with air in rare cases
Health Hazards: May cause mild irritation to eyes, skin, and respiratory tract on direct contact or inhalation of concentrated dust
Environmental Hazards: Not expected to present significant environmental hazards if handled properly
Signal Word: None required
Pictogram Elements: Not applicable
Chemical Substance: Folic Acid
Common Name: Vitamin B9
Chemical Formula: C19H19N7O6
Molecular Weight: 441.40 g/mol
Concentration (Purity): Typically above 95%, may contain trace levels of residual solvents or by-products
Impurities: Impurities present at non-hazardous trace levels
Inhalation: Move the exposed person to fresh air. If breathing becomes difficult, seek medical attention immediately.
Ingestion: Rinse mouth with water if person is conscious. Do not induce vomiting unless instructed by medical personnel.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with plenty of water. Wash with mild soap.
Eye Contact: Rinse eyes gently with running water for at least 15 minutes. Remove contact lenses if present and easy to do. Seek medical aid if irritation persists.
Symptoms and Effects: Temporary irritation or discomfort may occur with direct exposure. Immediate action helps lower adverse effects.
Advice for Medical Staff: Symptomatic treatment, as no specific antidote is available.
Suitable Extinguishing Media: Use water spray, dry chemical powder, foam, or carbon dioxide.
Unsuitable Extinguishing Media: Strong water jets may spread fire.
Specific Hazards: Dust can pose a minor explosion hazard in specific atmospheric conditions. Decomposition may produce carbon oxides, nitrogen oxides, and toxic fumes.
Firefighter Protection: Wear self-contained breathing apparatus and full protective gear. Avoid inhaling fumes.
Explosion Data: High dust concentrations can ignite under severe conditions, though the risk is low with normal handling.
Personal Precautions: Avoid dust inhalation and contact with skin, eyes, or clothing. Wear appropriate PPE. Remove ignition sources if large amounts are spilled.
Environmental Precautions: Prevent entry into waterways or drains. Contain runoff to avoid environmental exposure.
Methods for Cleanup: Scoop or vacuum spilled powder, taking care to minimize dust. Dispose of collected material in properly labeled containers.
Decontamination: Wash area thoroughly after removal, ensuring no residue remains that could create dust.
Safe Handling: Use in well-ventilated areas. Avoid creating airborne dust. Practice good industrial hygiene by washing hands after use and before eating. Do not breathe dust.
Storage Conditions: Keep container tightly closed in a cool, dry, well-ventilated place. Store away from strong oxidizers and direct sunlight.
Incompatibilities: Avoid storage with strong acids, strong bases, and oxidizing agents.
Packaging Materials: Use original containers or compatible materials that prevent absorption of moisture.
Exposure Limits: No specific occupational exposure limits established for folic acid, though dust exposure should be minimized by good ventilation.
Engineering Controls: Use local exhaust ventilation or process enclosure equipment to control airborne dust levels.
Eye Protection: Safety glasses with side shields or chemical goggles.
Skin Protection: Wear suitable resistant gloves and protective clothing.
Respiratory Protection: Use a NIOSH-approved dust mask or respirator if dust formation is likely.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Avoid eating or drinking when handling the material.
Appearance: Yellow or orange-yellow crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Slightly acidic to neutral in aqueous solution
Melting Point / Freezing Point: Decomposes above 250°C; does not have a well-defined melting point
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable
Flammability: Not easily ignited but may burn in strong fire
Vapor Pressure: Negligible at ambient temperature
Solubility: Sparingly soluble in water, soluble in alkaline solutions
Partition Coefficient: log Pow -2.8 (estimated)
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 250°C
Viscosity: Not applicable
Chemical Stability: Stable under normal storage and handling conditions.
Reactivity: Does not undergo hazardous reactions under correct storage and use.
Conditions To Avoid: Moisture, heat, light, sources of ignition.
Incompatible Materials: Strong acids, strong bases, oxidizers.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, and possible toxic fumes may result from thermal decomposition.
Acute Toxicity: Low toxicity if ingested or inhaled in small amounts. Large doses could cause gastrointestinal upset.
Skin Corrosion/Irritation: Not expected to cause significant irritation.
Serious Eye Damage/Irritation: Mild, temporary irritation possible.
Respiratory Sensitization: Rare and unlikely from normal handling.
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA or ACGIH.
Reproductive Toxicity: No evidence of reproductive toxicity at common exposure levels. Over-supplementation during pregnancy should be monitored.
Chronic Toxicity: Long-term exposure effects are limited but excessive intake may mask vitamin B12 deficiency.
Other Health Effects: Allergic reactions are extremely rare.
Ecotoxicity: Not expected to be harmful to aquatic organisms or wildlife based on available data.
Persistence and Degradability: Degradable in the environment. Rapid breakdown through microbial action is common.
Bioaccumulative Potential: Low potential for bioaccumulation in aquatic or terrestrial species.
Mobility in Soil: Slightly mobile, but unlikely to reach groundwater when handled properly.
Other Adverse Effects: No known significant hazards to the environment under normal usage or disposal practices.
Disposal Methods: Dispose of in accordance with local, regional, and national regulations. Do not release into drains or natural bodies of water.
Container Disposal: Clean containers may be recycled or disposed of as non-hazardous waste. Containers not clean should be treated as hazardous.
Special Considerations: Prevent emission of airborne dust during disposal by sealing in tightly closed bags or containers.
UN Number: Not regulated for transport
UN Proper Shipping Name: Folic Acid
Transport Hazard Class(es): Not classified as a hazardous material
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Transport Precautions: Protect from direct sunlight and damp during transport. Avoid rough handling and prevent container breakage.
Special Transport Information: Follow shipping regulations for pharmaceuticals or chemicals as applicable to the intended route and mode of transport.
OSHA Status: Not hazardous as defined by OSHA Hazard Communication Standard.
TSCA Status: Listed on the Toxic Substances Control Act (TSCA) inventory.
REACH (EU): Registered as a substance of low concern.
WHMIS (Canada): Not controlled under WHMIS.
Other Regulations: Folic acid is a permitted additive in foods and pharmaceuticals. Always ensure alignment with current local laws and limits for dietary supplements or additives.
Labeling: Not required as hazardous for labeling under GHS.
Restrictions: Oversupplementation may be regulated depending on jurisdiction and intended use.
