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Product Name: Flutamide
Synonyms: 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Chemical Formula: C11H11F3N2O3
Molecular Weight: 276.2 g/mol
Intended Use: Pharmaceutical ingredient for hormone therapy
CAS Number: 13311-84-7
Supplier Information: Contact local distributor or manufacturer
Emergency Contact: Local poison control center or emergency health provider
Hazard Class: Harmful if swallowed, toxic by inhalation, irritating to eyes, respiratory system, and skin
Signal Word: Warning
Health Hazards: May interfere with liver function, can cause allergic reactions, prolonged exposure leads to organ damage
Environmental Hazards: Toxic to aquatic life, risk of bioaccumulation, persistent in soil and water
Precautionary Statements: Avoid ingestion, inhalation, and prolonged skin contact; handle only with proper safety training and personal protective equipment
Chemical Name: Flutamide
Concentration: 99% (pharmaceutical grade)
Impurities: Trace solvents below 0.1%, manufacturing by-products below 0.05%
Other Components: No excipients present in raw bulk form
Inhalation: Remove person to fresh air immediately, seek medical attention right away if symptoms like coughing or shortness of breath appear
Skin Contact: Wash exposed skin with plenty of water and soap, remove contaminated clothing, seek medical help if irritation or rash shows up
Eye Contact: Rinse eyes carefully with water for at least 15 minutes, keep eyelids open, seek medical attention if pain or vision changes continue
Ingestion: Don’t induce vomiting, rinse mouth thoroughly with water, get urgent medical attention right away
Potential Symptoms: Nausea, headache, skin redness, respiratory discomfort, jaundice
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: Direct water jet can spread contaminated material
Hazards from Combustion: Emits toxic fumes including nitrogen oxides, carbon monoxide, fluorine-containing gases when burned
Precautions for Fire Fighters: Wear self-contained breathing apparatus and full protective gear to avoid inhaling hazardous smoke
Specific Procedures: Remove product containers from fire zone if safe, prevent fire run-off from contaminating drains and water sources
Personal Precautions: Use disposable gloves, chemical safety goggles, and laboratory coat, work in well-ventilated space
Environmental Precautions: Prevent chemicals from entering soil, sewers, surface water, or groundwater systems
Spill Clean-Up Methods: Collect spilled powder using HEPA-filtered vacuum or damp, disposable towels, transfer to labeled disposal container, avoid dust generation
Decontamination: Rinse spill area thoroughly using soapy water, ventilate affected space
Waste Disposal: Follow local hazardous waste regulations, don’t dispose with household garbage
Handling Precautions: Use only in designated and properly ventilated chemical safety areas, wash hands after handling
Storage Conditions: Store at room temperature in tightly closed containers, protect from moisture, sunlight, and strong oxidizers
Storage Incompatibilities: Separate from acids, alkalis, and reducing agents
Special Handling Practices: Always keep product in original or approved labeled container, limit access to authorized personnel
Engineering Controls: Work in certified chemical fume hood, equip room with eye wash station and emergency shower
Occupational Exposure Limits: None established for flutamide; minimize exposure as much as possible
Personal Protective Equipment: Wear chemical-resistant gloves, lab safety goggles, disposable coveralls, and mask; use respirator for airborne dust
Hygiene Practices: Remove contaminated clothing and launder before reuse, refrain from eating, drinking, or smoking in work area
Appearance: Pale yellow crystalline solid
Odor: Faint, slightly medicinal odor
Melting Point: 110–113°C
Boiling Point: Decomposes before boiling
Solubility: Sparingly soluble in water; soluble in acetone, ethanol, and dimethyl sulfoxide
Vapor Pressure: Negligible at room temperature
Density: About 1.5 g/cm³
pH: Not applicable in solid form
Stability: Stable under recommended storage conditions when dry and tightly sealed
Hazardous Reactions: May react with strong acids, bases, or oxidizing agents
Decomposition Products: Produces toxic gases like carbon monoxide, nitrogen oxides, hydrogen fluoride on heating or burning
Conditions to Avoid: Excess heat, moisture, sunlight, incompatible materials
Acute Toxicity: Oral LD50 (rat): 1278 mg/kg; toxic if significant amounts are ingested
Chronic Effects: Liver function disturbances, possible carcinogen in animals, not established in humans
Routes of Exposure: Skin contact, inhalation of dust, ingestion
Symptoms of Overexposure: Fatigue, abdominal discomfort, jaundice, nausea, headache
Sensitization: May cause skin sensitization or allergic reaction in predisposed individuals
Aquatic Toxicity: Harmful to fish and aquatic invertebrates at low concentrations
Persistence and Degradability: Degrades slowly in soil and water, risk of accumulation with repeated releases
Mobility in Soil: Moderately mobile; potential to reach groundwater
Bioaccumulation: Possible biomagnification in aquatic food chains
Ecological Advice: Never discharge untreated product or water contaminated with flutamide to natural waterways
Waste Disposal Methods: Dispose as hazardous chemical waste via licensed incineration
Container Disposal: Triple rinse empty containers with compatible solvent, puncture and dispose as hazardous materials
Do Not: Pour into drains, landfill, or mix with non-hazardous wastes
Minimize Waste: Use only quantities needed for process, store residuals for professional disposal
UN Number: Not classified under major international transport codes
Transport Hazard Class: No specific class, treat as toxic powdered chemical
Shipping Name: Flutamide, solid, n.o.s (not otherwise specified)
Packing Group: As per local transport regulations
Special Transport Advice: Carry in sealed, labeled containers, secure against spillage or leaks during transit, prevent exposure to unauthorized personnel
Labeling Requirements: Toxic, irritating, environmental hazard symbols as per local regulations
Regulatory Status: Subject to pharmaceutical and workplace safety laws in most regions
TSCA (US): Not listed as an industrial chemical
REACH (EU): Not registered under industrial supply, regulated as pharmaceutical substance
Other Regulations: Handle under authority of trained personnel only, observe all national and workplace health regulations
