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Product Name: Flurogestone Acetate / Fluoroprogesterone Acetate
Chemical Family: Synthetic Progestin Steroid
Synonyms: 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone
Molecular Formula: C23H29FO4
Recommended Use: Hormonal pharmaceutical agent, veterinary applications
Manufacturer Contact: Refer to product label for local supplier details
Emergency Telephone: Local or national poison center, or emergency medical response
GHS Classification: Reproductive toxicity, Specific target organ toxicity – repeated exposure
Hazard Statements: Suspected of damaging fertility or the unborn child, May cause organ damage through prolonged or repeated exposure
Pictograms: Health hazard symbol
Precautionary Statements: Avoid unnecessary exposure, Do not handle without protective equipment, Wash hands thoroughly after handling, Store locked up
Major Routes of Entry: Inhalation, Skin absorption, Ingestion, Eye contact
Target Organs: Endocrine system, Liver, Reproductive system
Chemical Name: Flurogestone Acetate
CAS Number: 2529-45-5
Percentage: >98% (active ingredient)
Impurities: Trace synthetic by-products, residual solvents (low levels)
Other Components: No significant additives or non-hazardous stabilizers
Inhalation: Move affected person to fresh air. Seek medical advice if irritation or respiratory symptoms persist. Remove any contaminated clothing and loosen tight garments, facilitate breathing.
Skin Contact: Remove contaminated clothing and wash affected skin with copious amounts of water and mild soap. If persistent irritation, rash, or sensitivity develops, consult a healthcare professional.
Eye Contact: Flush eyes for a minimum of 15 minutes with clean water, lifting eyelids occasionally. Avoid rubbing the eyes and seek prompt medical support if redness or discomfort remains.
Ingestion: Rinse mouth with plenty of water if person is conscious. Never give anything by mouth to someone unconscious. Contact poison control or a medical practitioner immediately. Induce vomiting only if directed by medical personnel.
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or alcohol-resistant foam. Select media appropriate for the surrounding fire.
Specific Hazards: Intense heat may produce toxic fumes of fluorine-containing compounds, carbon oxides, and possibly dioxins. Combustion products may include hydrogen fluoride gas.
Protective Equipment: Firefighters need full protective clothing, including self-contained breathing apparatus. Avoid inhalation of smoke, vapors, or residues from combustion.
Fire-Fighting Instructions: Move containers away from fire area if safe to do so. Cool fire-exposed containers with water spray. Prevent runoff from entering drains, surface, or ground water.
Personal Precautions: Evacuate unnecessary personnel from area. Wear protective gloves, goggles, protective clothing, and a certified respirator.
Environmental Precautions: Prevent chemical from reaching soil, surface water, or sewer system. Spills in water should be reported to appropriate authorities.
Cleanup Methods: Use inert absorbent materials (such as vermiculite, sand, or soil) to contain spill. Scoop up material in sealed containers labeled for hazardous waste. Immediately ventilate the area. Thorough decontamination with detergent and water recommended to reduce residue.
Disposal: Collect contaminated materials for specified hazardous chemical disposal.
Handling: Avoid breathing dust, vapors, or mists. Do not eat, drink, or smoke during use. Use with local exhaust ventilation to minimize exposure. Wear protective clothing and wash thoroughly after use.
Storage: Keep in original, tightly closed containers in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers or acids. Store securely and out of reach of unauthorized individuals. Store away from light and heat sources.
Transfer Procedures: Use only dedicated equipment for handling this compound. Avoid contact with moisture. Do not allow containers to be damaged or open in uncontrolled environments.
Exposure Limits: No established occupational exposure limits for this compound, though handle as hazardous pharmaceutical material.
Engineering Controls: Use chemical fume hood or local exhaust ventilation at points of dust or vapor generation.
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile recommended), protective laboratory coat, splash-resistant goggles or full face shield, NIOSH-approved respirator if exposure likely to exceed airborne levels.
Hygiene Measures: Remove PPE before leaving work area, shower and change clothes after handling, keep contaminated clothing out of home washing machines if possible.
Appearance: White to off-white crystalline powder
Odor: None or faint
Melting Point: 220–224 °C (decomposes)
Boiling Point: Data not available; decomposes before boiling
Solubility: Insoluble in water, soluble in chloroform, slightly soluble in methanol
Vapor Pressure: Negligible at room temperature
Density: Approx. 1.3–1.4 g/cm³
pH: Not applicable
Stability: Stable under recommended storage conditions, decomposes under light or heat
Chemical Stability: Stable in original container at ambient temperatures when protected from light and heat
Conditions to Avoid: Contact with strong acids or oxidizers, intense light, high temperatures
Incompatible Materials: Strong oxidizing agents, strong acids, base metals
Hazardous Decomposition Products: Hydrogen fluoride, carbon monoxide, carbon dioxide, possibly toxic fluorinated organic compounds
Reactivity: Non-reactive under normal handling conditions
Acute Toxicity: Limited animal data suggest low acute oral and dermal toxicity; more concern for repeated, chronic low-dose exposure due to hormone activity
Chronic Effects: May disrupt reproductive hormone cycles, linked to liver and endocrine changes, altered fertility
Sensitization: No reliable reports of dermal or respiratory sensitization, but contact can produce irritation
Carcinogenicity: Not classified as human carcinogen by IARC, NTP, or ACGIH. Limited long-term studies exist; use caution with repeated exposure.
Mutagenicity or Reproductive Toxicity: Classified as reproductive hazard; possible effects on fertility and fetal development documented in animal studies
Aspiration Hazard: Not expected
Ecotoxicity: Endocrine-disrupting properties of related hormones have been detected in exposed aquatic organisms. Derivatives may impact aquatic life even at trace levels.
Persistence and Degradability: Poorly biodegradable, tends to persist in soil and sediment, risk of bioaccumulation
Bioaccumulative Potential: Moderate due to lipid solubility, may concentrate in aquatic and terrestrial food chains
Mobility in Soil: Limited movement expected due to low water solubility
Other Adverse Effects: Considerable hazard to aquatic environments where veterinary use or disposal practices allow release of hormones
Waste Disposal Methods: Consider all material, absorbents, and contaminated clothing as hazardous chemical waste. Incinerate in licensed facility with effective pollution controls. Avoid landfill disposal wherever possible.
Contaminated Packaging: Rinse empty containers with solvent and dispose according to local hazardous waste regulations.
Precautions: Do not discharge to sewers, natural waters, or soil. Consult local and national regulations for chemical pharmaceutical waste.
UN Number: Not assigned, non-bulk not regulated under typical shipping codes
Proper Shipping Name: Regulated pharmaceutical product
Transport Hazard Class: Not classified as a dangerous good for transport
Packing Group: Not applicable
Special Precautions: Protect containers from physical damage, keep upright, secure for transit
Hazard Label: Required for bulk shipments, may be required in specific regions
Global Status: Regulated as a prescription pharmaceutical product, veterinary medicine in select countries
OSHA Status: Considered hazardous per OSHA criteria for pharmaceutical products
TSCA Status: Not listed for commercial distribution in the United States
WHMIS, EU, Other Classifications: Covered under pharmaceutical regulatory frameworks, subject to health and environmental controls
Restriction on Use: Strictly for qualified professional, research, or pharmaceutical manufacture
Community Right-to-Know: Not subject to SARA Title III, not listed as extremely hazardous, though workplace monitoring recommended
