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Product Name: Flurbiprofen
Chemical Name: 2-(2-fluoro-4-biphenylyl)propionic acid
CAS Number: 5104-49-4
Molecular Formula: C15H13FO2
Molecular Weight: 244.26 g/mol
Intended Use: Pharmaceutical active ingredient, nonsteroidal anti-inflammatory drug (NSAID)
Synonyms: Ansaid, Froben, Nalfon-2
Manufacturer/Supplier: Contact information required as per distributor
Recommended Restrictions: Use in accordance with label, research and medical use only
Classification: Eye irritation (Category 2), Specific target organ toxicity (single exposure, category 3), Reproductive toxicity (Category 2)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, may cause damage to organs through prolonged or repeated exposure, suspected of damaging fertility or the unborn child
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use personal protection recommended, keep container tightly closed
Routes of Exposure: Eyes, skin, inhalation, ingestion
Symptoms: Irritation to eyes and respiratory tract, headache, nausea, gastrointestinal disturbances, kidney effects after chronic exposure
Chemical Name: Flurbiprofen
Concentration: >98% by weight
Impurities and Stabilizing Additives: Trace levels of related biphenyl derivatives possible, not considered hazardous at tested concentrations
Other Components: Not applicable for pure substance
Inhalation: Move to fresh air, keep at rest, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, medical advice for persistent symptoms
Eye Contact: Rinse well with plenty of water for at least 15 minutes, hold eyelids open, remove contact lenses, seek immediate medical advice
Ingestion: Rinse mouth with water, do not induce vomiting unless directed, seek medical attention, provide symptomatic treatment
Most Important Symptoms: Eye and respiratory tract irritation, gastrointestinal discomfort
Notes for Doctor: Treat symptomatically, monitor for delayed effects, supportive care as indicated
Suitable Extinguishing Media: Dry chemical powder, foam, CO2, water spray
Unsuitable Extinguishing Media: Direct water jet may spread material
Hazardous Combustion Products: Carbon oxides, fluorinated compounds, irritating vapors
Special Protective Equipment: Full protective gear and self-contained breathing apparatus required
Specific Hazards: Dust may form explosive mixtures with air, products of combustion may cause irritation
Personal Precautions: Avoid dust generation, ensure adequate ventilation, avoid contact with skin and eyes, wear appropriate personal protective equipment
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid runoff into drains and surface water
Methods for Cleaning Up: Sweep up, collect in suitable containers for disposal, clean area with detergent and water, avoid dry sweeping which raises dust, use HEPA vacuum if available
Disposal: Dispose of according to local and national regulations, label and seal waste appropriately
Safe Handling Practices: Handle in well-ventilated area, use process enclosures, local exhaust ventilation, minimize dust generation and accumulation, do not breathe powders
Storage Conditions: Keep containers tightly closed, store in cool, dry, well-ventilated location, protect from direct sunlight, segregate from strong acids and oxidizers
Incompatible Materials: Strong oxidizing agents, acids, bases
Other Precautions: Keep away from food and drink, avoid release into the environment, use personal protective gear as described
Occupational Exposure Limits: Not established, minimize workplace exposure using good hygiene practice
Engineering Controls: Use local exhaust ventilation, closed systems, dust extraction
Eye Protection: Safety goggles or face shield
Hand Protection: Impervious gloves (nitrile, neoprene)
Respiratory Protection: NIOSH-approved mask, P3 filter if risk of dust inhalation
Skin Protection: Lab coat, long sleeves, closed-toe footwear
General Hygiene: No smoking, eating, or drinking in handling area, wash hands after use, remove contaminated clothing before entering dining areas
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: 3.8-4.2 (saturated solution)
Melting Point / Freezing Point: 116-117°C
Boiling Point: Decomposes before boiling
Flash Point: >180°C (closed cup)
Evaporation Rate: Non-volatile
Flammability: Dust may be combustible
Explosion Limits: Not established
Vapor Pressure: Negligible
Vapor Density: Not applicable
Density: 1.33 g/cm³
Solubility: Slightly soluble in water, soluble in methanol, ethanol, acetone
Partition Coefficient (log Kow): 4.0
Auto-ignition Temperature: Not determined
Decomposition Temperature: >190°C
Viscosity: Not applicable to solid
Chemical Stability: Stable under normal conditions of handling and use
Reactiveness: Reacts with strong oxidizing agents, acids and bases
Hazardous Reactions: Dust-air mixtures may be explosive
Conditions to Avoid: Avoid contact with incompatible materials, extreme heat, sources of ignition
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, irritant fumes
Polymerization: Will not occur under normal conditions
Acute Toxicity: LD50 (oral, rat): 133 mg/kg
Chronic Effects: Renal toxicity, gastrointestinal ulceration, potential for reproductive toxicity (teratogenic effects in animal studies), respiratory irritation
Skin Corrosion/Irritation: Mild irritant
Eye Damage/Irritation: Causes significant irritation
Respiratory Sensitization: May cause symptoms in sensitive individuals
Carcinogenicity: Not classified as carcinogenic to humans
Mutagenicity: Not mutagenic in standard test systems
Reproductive Toxicity: Possible risk, animal data suggests negative effects at high doses
Toxicity to Aquatic Life: Acute and chronic toxicity data to aquatic organisms limited, high concentrations potentially harmful
Persistence and Degradability: Not readily biodegradable, likely to persist in soil and water
Bioaccumulative Potential: Potential for bioaccumulation due to moderate partition coefficient
Mobility in Soil: Moderate mobility, may leach to groundwater in significant spillage
Other Adverse Effects: Avoid uncontrolled release into the environment, harmful to microorganisms in wastewater treatment
Environmental Precautions: Prevent direct release, inform authorities in the event of environmental contamination
Disposal Methods: Dispose of through licensed waste disposal contractor, chemical incineration or special landfill compliant with local regulations
Contaminated Packaging: Empty containers should be treated as hazardous, cleanse thoroughly before recycling or disposal
Special Precautions: Do not discharge into drains, sewers or natural water systems
Legal Compliance: Conform with regional, national, and international environmental rules
UN Number: Not classified for transport under United Nations recommendations
Proper Shipping Name: Not regulated as dangerous for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions for Transport: Prevent damage to packaging, avoid dust emission in transit, secure against leakage
Environmental Risks: Not subject to marine pollutant regulation, environmental precautions remain crucial in the event of cargo accident
EU Regulations: Flurbiprofen meets criteria for hazardous chemical, compliance with REACH and CLP required
US Regulations: Not listed on US TSCA inventory, subject to FDA regulation for pharmaceutical applications
Canada: DSL Non-listed, WHMIS classification D2B
RoHS/REACH Status: Not specifically restricted, but manufacture, storage, transport must meet health and environmental regulations
Other Local Regulation: Observe all applicable national laws and workplace safety rules, ensure proper training and documentation as per OSHA or equivalent
