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Product Name: Flupirtine Maleate
Synonyms: Flupirtine hydrogen maleate; Ethyl-N-[2-amino-6-(4-fluorobenzylamino)pyridine-3-yl] carbamate maleate
CAS Number: 75507-68-5
Molecular Formula: C15H17FN4O2·C4H4O4
Molecular Weight: 401.41 g/mol
Recommended Use: Pharmaceutical intermediate; research and development
Manufacturer: Refer to local supplier information
Emergency Contact Number: Refer to regional poison control or emergency hotline
Classification: Acute toxicity (Oral Category 3); Eye irritation (Category 2A); Skin irritation (Category 2)
Label Elements: GHS skull and crossbones, exclamation mark
Hazard Statements: Toxic if swallowed; Causes skin and serious eye irritation
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; do not eat or drink during use; wear protective gloves, clothing, eye, and face protection
Hazards Not Otherwise Classified: Possible central nervous system effects with high exposure
Substance: Flupirtine Maleate
CAS Number: 75507-68-5
Concentration: 98–100%
Impurities: Typical trace synthesis residuals, not considered hazardous under normal conditions
Formula: C19H21FN4O6
Description: Off-white to pale yellow powder
Inhalation: Remove person to fresh air; keep at rest; seek medical attention if symptoms such as headache, dizziness, or respiratory distress arise
Skin Contact: Remove contaminated clothing, wash with plenty of water and mild soap, seek medical help if irritation develops
Eye Contact: Rinse eyes thoroughly with plenty of water for at least 15 minutes; remove contact lenses if present and easy to do; get medical advice if irritation continues
Ingestion: Do not induce vomiting, rinse mouth with water; seek medical attention without delay
Most Important Symptoms and Effects: Burning eyes, redness, nausea, dizziness, drowsiness, gastrointestinal discomfort
Notes for Physicians: Symptomatic treatment, monitor vital signs, possible supportive therapy for CNS and hepatic effects
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Strong water jet
Specific Hazards Arising from Chemical: Combustion may produce toxic gases such as CO, CO₂, and nitrogen oxides
Protective Equipment and Precautions for Firefighters: Wear self-contained breathing apparatus and full protective gear to prevent inhalation of fumes and skin contact
Special Methods: Fight fire from upwind position, avoid dust formation
Personal Precautions: Wear suitable protective equipment; prevent dust cloud formation; ventilate area
Environmental Precautions: Prevent spilled material from entering drains, surface waters, or soil
Methods for Cleaning Up: Sweep up and place in suitable containers for disposal; wash contaminated area with water and detergent; avoid raising dust when collecting powder
Emergency Procedures: Evacuate unnecessary personnel, prevent further leakage or spillage
Handling: Work in well-ventilated area; avoid contact with skin, eyes, or clothing; minimize dust generation; use approved protective equipment
Storage: Store tightly closed in a cool, dry, well-ventilated place; keep away from incompatible materials such as strong oxidizing agents; protect from direct sunlight
Packaging Materials: Use containers that resist moisture ingress and protect from physical damage
Specific End Uses: Laboratory use, not for household use
Occupational Exposure Limits: Not established; minimize exposure wherever possible
Engineering Controls: Use local exhaust or general laboratory ventilation to control airborne exposure
Personal Protective Equipment: Chemical safety goggles, lab coat, nitrile gloves, dust respirator for poor ventilation or handling bulk amounts
Hygienic Practices: Wash hands after handling; do not eat, drink or smoke around the product; launder clothing after contact
Other Protection: Emergency eyewash and safety shower in proximity
Appearance: Off-white to pale yellow powder
Odor: No significant odor
Odor Threshold: Not available
pH: 4.0–5.0 (1% solution in water)
Melting Point: 197–201°C
Boiling Point: Not available (decomposes before boiling)
Flash Point: Not established; combustible solid
Evaporation Rate: Not applicable
Flammability: Not highly flammable, but may burn
Vapor Pressure: Not determined
Vapor Density: Not determined
Relative Density: Not determined
Solubility: Soluble in water, slightly soluble in alcohol and methanol
Partition Coefficient (log Kow): Not available
Auto-ignition Temperature: Not available
Decomposition Temperature: >200°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended conditions of storage and handling
Conditions to Avoid: High humidity, heat, direct sunlight, ignition sources
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, possibly hydrogen fluoride on combustion
Possibility of Hazardous Reactions: No known hazardous polymerization
Acute Toxicity: LD50 (oral, rat) ~100–200 mg/kg; toxic if swallowed
Skin Corrosion/Irritation: Causes skin irritation with repeat or prolonged exposure
Serious Eye Damage/Irritation: Causes severe eye irritation
Respiratory or Skin Sensitization: Not classified as a sensitizer, but avoid repeated contact
Germ Cell Mutagenicity: Not classified
Carcinogenicity: No data in humans; animal studies limited
Reproductive Toxicity: Insufficient evidence for classification
STOT – Single Exposure: May affect central nervous system, drowsiness possible
STOT – Repeated Exposure: Risk of liver effects with chronic exposure
Aspiration Hazard: Not classified
Other Information: Potential adverse hepatic and neurological effects based on reported overdose cases
Ecotoxicity: No specific data for aquatic toxicity; low solubility may limit acute hazards
Persistence and Degradability: Not readily biodegradable, may persist under certain environmental conditions
Bioaccumulative Potential: Low, due to moderate water solubility and molecular size
Mobility in Soil: Moderate mobility, may leach in sandy soils
Other Adverse Effects: Avoid release to environment; actual impact depends on quantity and local conditions
Waste Treatment Methods: Dispose of as hazardous chemical waste according to local regulations
Product Disposal: Incinerate or use chemical disposal contractor approved for pharmaceutical or laboratory chemicals
Contaminated Packaging: Triple rinse then puncture packaging before disposal; conform to local disposal requirements
Other Advice: Avoid environmental release; do not throw in household garbage
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: Not marine pollutant
Transport in Bulk: Not intended for bulk transport per Annex II of MARPOL 73/78 and the IBC Code
Special Precautions: Transport in closed containers; prevent spillage and exposure during transit
Global Inventory Status: Not listed as a controlled substance under current international conventions
GHS Classification: Toxic, irritant — GHS symbology and labeling recommended
OSHA Status: Not specifically regulated; handle under general laboratory safety standards
EPA Status: Not listed
EU Regulations: Not REACH registered; subject to workplace and laboratory regulations
Other National/International Regulations: Refer to country-specific guidelines and pharmaceutical workplace controls
