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Material Safety Data Sheet: Flunixin Meglumine

Identification

Product Name: Flunixin Meglumine
Chemical Name: 2-(2-Methyl-3-(trifluoromethyl)anilino)nicotinic acid, compound with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
Synonyms: Flunixamine, Banamine
CAS Number: 42461-84-7
Recommended Use: Non-steroidal anti-inflammatory for veterinary purposes
Manufacturer/Supplier: Contact details provided on packaging, emergency contact phone and address available
Product Code: Listed on container and carton
Emergency Phone: Included on labeling materials for 24-hour support
Email: Refer to packaging for updated contact

Hazard Identification

GHS Classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 2, Eye Irritation Category 2A, Specific Target Organ Toxicity (Repeated Exposure) Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause damage to organs through prolonged exposure
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid contact with eyes, skin, clothing; wash thoroughly after handling; avoid eating, drinking, or smoking in work area; use only outdoors or in well-ventilated area; wear protective gloves/clothing/eye protection; do not breathe dust or vapor
Other Hazards: May pose reproductive toxicity based on animal studies; dust can aggravate respiratory symptoms; not for human medicinal use

Composition / Information on Ingredients

Component: Flunixin Meglumine
CAS Number: 42461-84-7
Concentration: ≥95%
Impurities: Contains trace levels of manufacturing residuals, not regarded as significant health hazards
Formulation: Can be powder or injectable solution; excipients depend on specific veterinary product formulation

First Aid Measures

Inhalation: Remove from exposure area to fresh air, seek medical attention for persistent symptoms such as coughing, shortness of breath, or wheezing
Skin Contact: Remove contaminated clothing and wash affected skin thoroughly with soap and water, seek medical advice if irritation or reaction persists
Eye Contact: Rinse eyes with plenty of water for 15 minutes, lifting eyelids to ensure complete rinsing, call for immediate medical help if irritation or vision changes occur
Ingestion: Rinse mouth with water, do not induce vomiting, call poison control and seek immediate medical attention
Note to Physician: Treat symptomatically, monitor for delayed and systemic effects

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or foam for surrounding fire
Unsuitable Media: Avoid heavy water stream which may spread the substance
Fire Hazards: Flunixin Meglumine is not highly flammable but thermal decomposition can produce harmful gases
Explosion Hazards: Dust can form explosive mixtures in air if allowed to accumulate
Special Precautions: Use water spray to cool containers, avoid inhaling combustion products
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective suit
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen fluoride, other toxic vapors

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel, wear protective mask, gloves, goggles
Environmental Precautions: Prevent entry into drains, waterways, soil; contain spills with absorbent materials such as sand or vermiculite
Cleanup Methods: Sweep up and collect spillage without raising dust, place in properly labeled containers for disposal as hazardous waste
Decontamination: Clean area with water and detergent, ventilate until thoroughly dry
Disposal: Consult regulatory agencies for environmentally safe disposal practices
Additional Advice: Consider suitability of PPE in the case of large quantities

Handling and Storage

Handling: Use only in areas with adequate ventilation; avoid creating dust, handle with gloves and eye/face protection, minimize exposure by working under fume hoods or using local exhaust ventilation; never eat, drink, or smoke in work area
Hygiene: Thoroughly wash after handling material, do not handle until safety precautions have been read and understood
Storage Conditions: Store in tightly closed original containers, away from light and incompatible chemicals; keep storage area cool, dry, and secure; restrict access to authorized personnel
Incompatibilities: Strong acids, oxidizers, and bases
Special Storage Considerations: Protect from moisture, keep separation from food, beverages, or animal feed

Exposure Controls and Personal Protection

Exposure Limits: Not established for Flunixin Meglumine; recommend keeping airborne concentrations as low as possible
Engineering Controls: Use fume hoods, local exhaust ventilation, and dust containment systems
Personal Protective Equipment: NIOSH-approved respirator for airborne dust, chemical resistant gloves (nitrile or neoprene), safety goggles, lab coat, long pants, and closed shoes
Hygiene Measures: Wash hands and face thoroughly after handling, remove contaminated clothing and wash before reuse
Environmental Controls: Prevent release to environment; capture dust at source; use containment methods for spills

Physical and Chemical Properties

Appearance: White to off-white crystalline powder or clear colorless solution
Odor: Odorless or practically odorless
Odor Threshold: Not determined
pH: About 8-9 in 1% aqueous solution
Melting Point: Decomposes above 270°C
Boiling Point: Not applicable for solid
Flash Point: Not flammable under normal conditions
Evaporation Rate: Not applicable
Flammability: Not readily flammable
Vapor Pressure: Negligible
Vapor Density: Not measured
Relative Density: Around 1.29 g/cm³
Solubility: Freely soluble in water and most organic solvents
Partition Coefficient (log Kow): Not established
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 270°C
Viscosity: Not applicable for solid
Other Properties: Forms stable solutions at recommended storage conditions

Stability and Reactivity

Chemical Stability: Stable under normal temperature and dry storage conditions
Reactivity: Does not react violently under storage, but may react with strong oxidizers or acids
Conditions to Avoid: Excessive moisture, prolonged exposure to heat or sunlight
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Hazardous Decomposition Products: Produces toxic and corrosive fumes of carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen fluoride during combustion or decomposition
Possibility of Hazardous Reactions: Will not polymerize

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Low oral LD50 in laboratory animals (500-1000 mg/kg in rats), skin and eye irritation observed at higher doses
Symptoms of Exposure: Headache, dizziness, nausea, abdominal pain, diarrhea; possible allergic skin reaction, redness, and pain
Chronic Effects: Possible kidney or liver effects with repeat high exposure; data in animals suggest potential reproductive/developmental risks
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: No mutagenic effects detected in standard laboratory studies
Reproductive Toxicity: Reproductive effects reported in animal studies at high doses, always consult risk assessment for workplace exposure limits
Other Toxic Effects: Prolonged or repeated exposure may aggravate pre-existing organ conditions

Ecological Information

Ecotoxicity: Harmful to aquatic organisms; studies show adverse effects in aquatic invertebrates and fish at low concentrations
Persistence and Degradability: Poorly biodegradable; may persist in soil and water for extended periods
Bioaccumulative Potential: Potential for moderate bioaccumulation, long-term environmental presence possible
Mobility in Soil: Moderate mobility; risk of groundwater contamination where large spills occur
Other Effects: Do not allow to enter surface waters, sewage system, or soil
Environmental Precautions: Treat residues as hazardous, minimize environmental release, and use containment for liquid waste

Disposal Considerations

Product Disposal: Dispose of material in accordance with local, regional, or national regulations for hazardous pharmaceutical waste
Container Disposal: Rinse containers, destroy by crushing, and dispose in approved landfill or incinerate if permitted
Contaminated Packaging: Handle as hazardous waste, avoid reuse
Recommended Method: High-temperature incineration with flue gas scrubbing where possible for safe destruction
Precautions: Prevent release to environment during disposal, keep documentation of waste manifest for audits
Special Instructions: Consult specialized firms for bulk or expired product disposal

Transport Information

UN Number: None assigned for small quantities
Proper Shipping Name: Flunixin Meglumine or Veterinary medicinal product, n.o.s.
Transport Hazard Class: Not regulated under UN, IMO, or IATA standards for standard shipments
Packing Group: Not classified
Environmental Hazards: Not a marine pollutant in small volumes, but significant spills should be reported per national guidelines
Special Precautions: Ship in original, leak-proof containers; observe any packaging and labeling requirements for veterinary medicines

Regulatory Information

US Federal Regulations: Not listed as controlled substance; regulated as hazardous chemical under OSHA Hazard Communication Standard; subject to FDA veterinary regulations
Canada WHMIS: Classified as hazardous under WHMIS 2015 (GHS) criteria
EU Regulation: Subject to REACH, not on candidate list of Substances of Very High Concern
Inventory Status: Listed in TSCA, EINECS, and other chemical inventories
Other Regulatory Data: Use restricted to licensed veterinary professionals; end-user liable for compliance with waste management and environmental protection laws
Labeling Requirements: Follow labeling guidance for hazardous chemical products and animal health rules
Additional Notes: Safety datasheets must be reviewed by workers before use, and those responsible for transport or storage must have up-to-date records