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Product Name: Flumethasone Acid
Chemical Formula: C22H28F2O5
Synonyms: 6α,9α-Difluoro-16α-methylprednisolone acid
Manufacturer: See product label for supplier details
Recommended Use: Pharmaceutical intermediate, research chemical
Contact Information: Available on the product label or through supplier documentation
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific organ toxicity (Repeated exposure, Category 2)
Signal Word: Warning
Hazard Statements: Causes skin and serious eye irritation; suspected of damaging fertility or the unborn child (reproductive toxicity); may cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Do not breathe dust or fumes; wash hands thoroughly after handling; use only in a well-ventilated area; wear protective eye protection and gloves
Health Hazards: Potential respiratory tract irritation, allergic skin reactions, possible reproductive effects
Physical Hazards: Dust can form explosive mixture with air
Environmental Hazards: Harmful to aquatic organisms, may cause long-lasting adverse effects in the aquatic environment
Chemical Identity: Flumethasone Acid
CAS Number: 2385-63-9
EC Number: Not assigned
Concentration: 98% or higher (as indicated by supplier)
Impurities: Trace process contaminants, see certificate of analysis
Molecular Weight: 410.5 g/mol
Inhalation: Remove person to fresh air, seek medical attention if respiratory symptoms develop
Skin Contact: Wash area thoroughly with plenty of water and mild soap, remove contaminated clothing
Eye Contact: Rinse gently with water for at least 15 minutes, seek medical attention if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice
Most Important Symptoms: Irritation to mucous membranes, redness, allergic reactions possible
Protection for Responders: Use gloves and eye protection, avoid dust exposure during aid
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Media: High-pressure water jets
Fire Hazards: Combustible powder, may form flammable dust clouds in air
Hazardous Decomposition Products: Carbon oxides, hydrogen fluoride, possible release of toxic fumes
Protective Equipment: Self-contained breathing apparatus, sealed protective clothing
Firefighting Procedures: Cool exposed containers, avoid breathing combustion products
Personal Precautions: Wear protective gloves, goggles, dust mask; ventilate area
Environmental Precautions: Prevent entry into drains and surface waters
Cleanup Methods: Sweep up without creating dust, use damp cloth or HEPA vacuum, collect in sealed container for disposal
Decontamination: Wash affected area with water and detergent, ventilate place after cleanup
Disposal: Follow local, regional, national, and international regulations
Handling: Avoid direct contact, minimize dust generation, use local exhaust ventilation, keep container tightly closed
Storage Conditions: Store in a cool, dry, well-ventilated location, protect from light and moisture
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Special Requirements: Keep out of reach of unauthorized personnel, label storage area clearly, store only in original container
Exposure Limits: No occupational exposure limits assigned. Avoid unnecessary exposure
Engineering Controls: Local exhaust ventilation, enclosed process equipment
Personal Protective Equipment: Chemical-resistant gloves, splash-proof goggles, lab coat, suitable respiratory protection if dust is generated
Hygiene Measures: Wash hands before eating or using restroom, remove contaminated clothing before entering rest areas
Environmental Controls: Procedures to limit release to the environment, regular monitoring where possible
Physical State: Off-white to pale yellow powder
Odor: No distinctive odor
pH: Not applicable (solid)
Melting Point / Freezing Point: 238°C to 244°C (literature value)
Boiling Point: Data not available
Flash Point: Not established
Solubility: Slightly soluble in water, freely soluble in organic solvents (ethanol, methanol, acetone)
Partition Coefficient (Log Kow): Approx. 2.45 (estimated)
Density: Approx. 1.36 g/cm³
Vapor Pressure: Negligible at room temperature
Other Properties: Non-volatile, stable under standard conditions, may generate dust
Chemical Stability: Stable at ambient temperature and pressure in sealed containers
Reactivity: Non-reactive under standard conditions
Conditions to Avoid: Excess heat, moisture, open flames, incompatible materials
Incompatible Materials: Strong oxidizers, strong acids or bases
Hazardous Decomposition: Carbon monoxide, carbon dioxide, hydrogen fluoride, potentially bioactive residues on combustion
Polymerization: No hazardous polymerization expected
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Irritation to eyes, skin and respiratory tract observed in laboratory studies; ingestion may cause gastrointestinal discomfort
Chronic Effects: Long-term exposure may cause reproductive and organ toxicity, possible skin sensitization reported
Toxicity Data: No established LD50 for humans; animal studies suggest mild to moderate toxicity
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Additional Information: May cause reproductive or developmental toxicity at high exposure levels based on structurally similar corticosteroids
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects based on ingredient structure
Soil Mobility: May persist in soil and water, low biodegradability estimated
Persistence and Degradability: Slow in soil and aquatic environments, risk of accumulation
Bioaccumulation: Potential moderate risk based on partition coefficient
Other Adverse Effects: No ecological warnings on ozone, greenhouse gas or PBT/vPvB criteria reported
Environmental Fate: Seek to limit environmental release, follow best practice for chemical waste handling
Disposal Methods: Incinerate in chemical incinerator conforming to local, regional, and national regulations
Unused Product: Treat as hazardous waste; do not discharge into drains or waterways
Disposal Containers: Use clearly marked, sealed chemical waste bins
Contaminated Packaging: Dispose as chemical waste; triple rinse then destroy or recycle if allowed by local codes
Precautions: Wear appropriate PPE when handling waste; minimize dust and environmental release
UN Number: Not classified as dangerous goods for transport
Transport Hazard Class: N/A
Packing Group: N/A
Labeling Requirements: Ensure labeling according to chemical safety standards
Environmental Hazards: Not regulated as marine pollutant but avoid release into environment
Special Precautions: Ship only in well-sealed, clearly labeled containers; protect from extreme temperatures and physical damage
Safety, Health and Environmental Regulations: Subject to chemical inventory regulations where applicable; not listed as a controlled drug or precursor
GHS Classification: Covered under international chemical safety standards
Workplace Safety: Comply with Occupational Safety and Health Administration requirements
Labeling: Requires hazard and precautionary statements per local regulations
Other Regulatory Notes: Not listed on US TSCA inventory; may have restrictions in some countries for sale/use outside of laboratory or pharmaceutical environments
