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Product Name: Fludrocortisone Acetate
Synonyms: 9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione 21-acetate
Chemical Family: Corticosteroid
Molecular Formula: C23H31FO6
CAS Number: 514-36-3
Intended Use: Pharmaceutical ingredient, laboratory research
Manufacturer: Contact supplier for specific address
Emergency Phone Number: Refer to local poison control center or safety department
GHS Classification: Hazardous to aquatic environment (chronic), Category 3
Label Elements: Exclamation mark symbol
Signal Word: Warning
Hazard Statements: May cause skin irritation. Possible risk of eye irritation. May cause respiratory irritation. Can be harmful to aquatic life with long-lasting effects. May disrupt endocrine activity.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear protective gloves, clothing, and eye protection.
Chemical Name: Fludrocortisone Acetate
Concentration: 100% by weight
CAS Number: 514-36-3
Impurities/Additives: Typically absent; consult batch-specific data for details
Inhalation: Move person to fresh air. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Rinse with flowing water for at least 15 minutes. Seek medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for 15 minutes, lifting eyelids if needed. Get medical attention if redness or pain continues.
Ingestion: Rinse mouth with water, do not induce vomiting. Get immediate medical help.
Advice to Physician: Symptomatic treatment; monitor adrenal suppression in exposed persons
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Media: Avoid high-pressure water streams that may scatter powder
Hazardous Combustion Products: Hydrogen fluoride, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Full protective gear including self-contained breathing apparatus
Special Precautions: Ventilate closed spaces after fire, avoid inhaling combustion gases
Personal Precautions: Use appropriate personal protective equipment. Avoid dust formation. Prevent contact with exposed skin and eyes.
Environmental Precautions: Prevent entry into sewers, drains, and waterways.
Cleanup Methods: Carefully sweep up and place in suitable container for disposal. Avoid creating airborne dust. Ventilate area as much as possible.
Precautions for Safe Handling: Handle under localized enclosure or fume hood whenever possible. Wear protective gloves, clothing, and eye/face shields.
Conditions for Safe Storage: Store in tightly closed container in a cool, dry, well-ventilated area away from incompatible materials. Avoid direct light and humidity.
Safe Packaging Materials: Use original packaging or HDPE containers. Label clearly with product name and hazard warnings.
Engineering Controls: Use containment, local exhaust ventilation, or fume extraction to reduce airborne exposure.
Personal Protective Equipment: Eyes: Chemical splash goggles or face shield. Skin: Disposable lab coat, nitrile gloves. Respiratory: Mask with P2 or higher filter if dust may be present.
Exposure Limits: Not established for this specific substance. Minimize exposure to lowest achievable level.
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not determined
Melting Point: 260-265°C
Boiling Point: Decomposes before boiling
Solubility: Poorly soluble in water, soluble in acetone, chloroform, and methanol
Vapor Pressure: Negligible at room temperature
Partition Coefficient: log Kow >3.0 (estimated)
Flash Point: Not determined
Autoignition Temperature: Not determined
Explosion Limits: Not available
Chemical Stability: Stable in dry, ventilated storage under recommended conditions
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Hydrogen fluoride, carbon oxides
Conditions to Avoid: Excess moisture, heat, direct sunlight
Acute Toxicity: Not well studied, though corticosteroids can cause long-term endocrine effects at low doses
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Skin/Eye Irritation: Causes mild to moderate irritation; may worsen existing dermatitis
Chronic Effects: Prolonged exposure may cause adrenal suppression, immunosuppression, and metabolic changes
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Sensitization: Not expected with occupational exposure, but allergic reactions have been reported in some individuals
Other Data: Prolonged exposure, especially when inhaled or ingested, can disrupt normal hormone function
Ecotoxicity: May cause long-term adverse effects in aquatic ecosystems; corticosteroids have shown toxicity to aquatic organisms at low concentrations
Persistence and Degradability: Moderate persistence in the environment, slow biodegradation
Bioaccumulative Potential: Potential for bioaccumulation based on octanol-water partition coefficient
Mobility in Soil: Limited mobility due to low solubility in water
Other Adverse Effects: Endocrine disruption can impact wildlife populations at environmental concentrations
Waste Treatment Methods: Dispose of as hazardous pharmaceutical waste according to local, regional, and national regulations.
Contaminated Packaging: Rinse containers well before disposal. Do not re-use empty containers.
Environmental Precautions: Do not release into environment or drains; incinerate waste where permitted.
UN Number: Not assigned
UN Proper Shipping Name: Not regulated as hazardous for transport
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Precautions: Package securely to prevent breakage and avoid dust emission during transit
Inventory Status: Listed or exempt according to national chemical inventories (TSCA, REACH, DSL)
Regulatory Lists: Not regulated as a controlled substance; classified for environmental hazard in some regions
SARA Title III: Not a reportable substance
California Proposition 65: Not listed
Workplace Classification: May require specific labeling and precautions under OSHA or EU Directives depending on setting.
