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Product Name: Fleroxacin
Chemical Name: 1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
CAS Number: 85634-17-9
Supplier: Pharmaceutical providers, chemical distributors
Recommended Use: Antibacterial agent, prescription medication
Synonyms: Fleroxacinum, Ro 23-6240/001
Classification: Harmful if swallowed, may cause serious eye irritation, might sensitize respiratory system
Hazard Statements: Exposure can result in nausea, headache, dizziness; may aggravate existing neurological disorders; severe eye discomfort possible
Pictograms: Exclamation mark, health hazard
Signal Word: Warning
Precautionary Statements: Avoid contact with eyes and skin; do not inhale dust; keep away from food and beverages; maintain good industrial hygiene practices
Chemical: Fleroxacin
Concentration: Pure compound or as specified by supplier
Impurities: Minor trace solvents and moisture content (<1%) present from manufacturing process
Molecular Formula: C17H18FN3O3
Molecular Weight: 331.34 g/mol
Inhalation: Transfer to fresh air; seek medical attention if symptoms persist
Skin Contact: Rinse skin thoroughly with water and mild soap; remove contaminated clothing
Eye Contact: Flush immediately with large amounts of water for at least 15 minutes; seek care if irritation continues
Ingestion: Rinse mouth with water; do not induce vomiting; get medical help right away
Notes for Physician: Supportive treatment; monitor neurological symptoms and renal function
Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Special Hazards Arising from Substance: May generate toxic fumes consisting of nitrogen oxides and fluorinated compounds
Protective Equipment: Full-face self-contained breathing apparatus, chemical-resistant suit
Advice for Firefighters: Minimize environmental runoff by containing fire water; keep containers cool using water spray
Personal Precautions: Wear gloves, safety goggles, and dust mask if powder present; ensure adequate ventilation
Environmental Precautions: Prevent spillage from entering drains or waterways
Methods for Containment: Use spill control material to limit spread; pick up mechanically or vacuum with HEPA filter
Clean-Up: Place waste in suitable closed containers for disposal; ventilate area after cleanup
Safe Handling: Avoid inhaling dust or vapors; avoid contact with eyes, skin, and clothing; wash hands after handling; operate in well-ventilated area; use in designated areas
Storage Conditions: Store in tightly sealed containers; keep in cool, dry, well-ventilated place; protect from direct sunlight and incompatible substances (oxidizing agents, strong acids)
Incompatibilities: Avoid contact with oxidizers, acids and bases due to risk of degradation or reaction
Recommended Engineering Controls: Fume hood or local exhaust ventilation
Personal Protective Equipment (PPE): Chemical-resistant gloves, protective eyewear, lab coat, dust mask or respirator if insufficient ventilation
Exposure Limits: No established occupational exposure limits, handle using minimal exposure principles; use biological monitoring if risk of significant absorption exists
Hygiene Measures: Change contaminated clothing; wash thoroughly after handling and prior to eating or drinking
Appearance: White to pale yellow crystalline powder
Odor: Odorless or slightly characteristic chemical scent
Melting Point: 210-214°C
Boiling Point: Decomposes before boiling
Solubility: Sparingly soluble in water, more soluble in organic solvents (methanol, ethanol, DMSO)
pH: Slightly acidic to neutral in aqueous solution
Partition Coefficient: Log P values report less than 1.5 at 25°C
Vapor Pressure: Negligible at ambient temperature
Bulk Density: Approximately 500-800 kg/m3 depending on particle size
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No significant reactivity under normal conditions
Hazardous Reactions: Reacts with strong oxidizing agents and strong acids
Decomposition Products: Yields toxic nitrogen oxides, carbon monoxide, carbon dioxide, and hydrogen fluoride on thermal decomposition
Conditions to Avoid: Exposure to excessive heat, moisture, light, and incompatibles mentioned above
Acute Toxicity: Oral LD50 (rat): > 2000 mg/kg; data suggests moderate acute oral toxicity
Symptoms of Exposure: Headache, dizziness, gastrointestinal upset including nausea or diarrhea, rash, potential photosensitivity; rare nervous system effects such as insomnia or confusion
Chronic Effects: Long-term exposure could affect liver and kidney function, risk of effects on cartilage in juvenile animals; not classified as carcinogen but not enough human data
Sensitization: Possible skin or respiratory sensitization based on animal studies
Other Data: Not mutagenic under standardized testing; not shown to be teratogenic or affect reproductive organs at therapeutic exposures
Ecotoxicity: Harmful to aquatic organisms at high concentrations; potential for bioaccumulation
Aquatic Toxicity: LC50 fish > 100 mg/L; EC50 daphnia > 100 mg/L; not readily biodegradable in standard OECD tests
Mobility: Little mobility in soil; tends to adsorb to sediment and organic matter
Persistence: Moderate environmental persistence; slowly degraded in soil or surface water
Bioaccumulation: Evidence for low to moderate potential based on chemical structure and partitioning data
Disposal Methods: Dispose of in accordance with local, regional, and national regulations for hazardous pharmaceutical waste; incinerate in approved facility or deliver to an authorized hazardous waste contractor
Contaminated Packaging: Rinse containers thoroughly before recycling or disposal; treat as hazardous waste if heavily contaminated
Environmental Precautions: Avoid release into sewer systems, surface water, or general waste streams; notify authorities if large quantities released
UN Number: Not classified as dangerous goods by ADR/RID, IMDG, IATA
Proper Shipping Name: Pharmaceutical product, non-hazardous for transport
Packing Group: Not regulated
Special Transport Precautions: Ship in well-sealed packaging, protected from breaking or leakage; follow all regulations for pharmaceutical material transfers
Marine Pollutant: Not specifically listed but restrict large-scale discharges near water
GHS Classification: Eye irritation, specific target organ toxicity after single exposure
Status under TSCA: Not listed for non-industrial uses
WHMIS Classification: D2B (Toxic material causing other toxic effects, Canada)
REACH: Registered only as permitted active pharmaceutical substance
Other Regulations: Controlled under prescription laws; environmental release reporting requirements applied in certain jurisdictions; relevant workplace safety and health regulations apply
Labeling Requirements: Substance and hazard details required on all primary and secondary containers
