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Product Name: Finerenone
Chemical Name: 4-[5-(4-Cyanophenyl)-1,2,4-oxadiazol-3-yl]-2-methyl-5-pyridin-4-yl-1H-imidazol-3(2H)-one
Synonyms: BAY 94-8862
CAS Number: 1962927-67-1
Recommended Use: Pharmaceutical ingredient, research chemical
Supplier Information: Available through licensed pharmaceutical distributors or chemical suppliers
Emergency Contact: Refer to local regulations for poison control or emergency medical advice
Classification: Not classified as hazardous under GHS for commercial/research handling but may pose risks typical of heterocyclic organic compounds
Physical Hazards: Dust may cause eye or respiratory tract irritation if inhaled in large amounts
Health Hazards: May cause irritation on exposure to eyes, skin, or respiratory system; ingestion may affect cardiovascular or renal systems, based on pharmacology data
Symbols: No specific symbols assigned under CLP-regulation
Precautionary Statements: Avoid inhaling powder, prevent skin and eye contact, use only in well-ventilated areas
Signal Word: Warning
Chemical: Finerenone
Concentration: >98% as supplied
Molecular Formula: C21H20N4O3
Molecular Weight: 376.41 g/mol
Impurities: May contain trace synthesis byproducts (details from certificate of analysis)
Inhalation: Move person to fresh air, keep comfortable, seek medical help for symptoms
Skin Contact: Remove contaminated clothing, wash skin thoroughly with water and soap
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical advice if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Medical Attention/Special Treatment: Supportive treatment based on symptoms, provide MSDS to healthcare professionals
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Media: Avoid high-pressure water jets which may spread powder
Specific Hazards: Combustion may produce toxic fumes including carbon monoxide, nitrogen oxides, and hydrogen cyanide
Protective Equipment: Full protective clothing, self-contained breathing apparatus
Firefighting Instructions: Move containers from fire area, keep cool with water spray, avoid inhaling fumes
Protective Equipment: Wear gloves, laboratory coat, protective goggles, particulate respirator
Spill Response: Avoid raising dust, sweep up gently, collect in sealed containers for disposal, ventilate area
Environmental Precautions: Prevent entry into drains, sewers, or waterways
Cleanup Methods: Wash spill area with water and detergent after material pick-up
Handling: Minimize dust formation, avoid breathing powder, handle in a fume hood or ventilated area, wear recommended PPE
Storage Conditions: Store at 2–8°C in tightly closed original container, keep away from light and moisture
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Special Requirements: Protect from heat, moisture, and direct sunlight
Engineering Controls: Use local exhaust ventilation or chemical fume hood
Personal Protective Equipment: Nitrile gloves, safety glasses, laboratory coat, particulate mask or respirator
Hygiene Measures: Wash hands after use, remove contaminated clothing
Exposure Limits: No established occupational exposure limits for finerenone; minimize exposure as a precaution
Appearance: White or off-white crystalline powder
Odor: Odorless
pH: No data available (insoluble in water solutions at standard conditions)
Melting Point: ~250°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Water Solubility: Poorly soluble in water
Solubility (other): Soluble in DMSO, ethanol
Density: Not established
Partition Coefficient (log P): Estimated 2–3 based on structure
Vapor Pressure: Not significant at room temperature
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No known reactivity under normal use
Hazardous Reactions: May react with strong oxidizers producing hazardous gases
Decomposition Products: Oxides of carbon and nitrogen, hydrogen cyanide in fire conditions
Conditions to Avoid: Moisture, high temperatures, exposure to sunlight, strong acids and bases
Acute Toxicity: Limited human data; animal studies show low acute toxicity, with effects seen at high doses
Routes of Exposure: Inhalation, ingestion, eye and skin contact
Symptoms: Irritation to eyes, skin, respiratory system; possible cardiovascular or renal effects if ingested in quantity
Chronic Effects: Long-term exposure data unavailable; ongoing studies focus on specific organ systems
Carcinogenicity: No components identified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: In vitro and in vivo studies show no genetic toxicity at therapeutic doses
Reproductive Toxicity: Studies and data limited to animal models; effects in humans unknown
Aquatic Toxicity: Data not fully available, but related structures may cause harm to aquatic organisms at high concentrations
Degradability: Persistent under environmental conditions, not readily biodegradable
Bioaccumulation: Potential bioaccumulation cannot be excluded based on structure
Mobility in Soil: Poor water solubility likely limits mobility, but slow degradation increases long-term presence
Other Effects: Long-term impacts on ecosystems are unknown; responsible management reduces risk
Disposal Methods: Send to licensed hazardous waste facility in accordance with local, state, and national regulations
Disposal of Contaminated Packaging: Dispose of as hazardous waste
Incineration: Suitable for destruction, controlling for emissions
Do Not: Discharge to waterways or regular landfill
UN Number: Not classified as a dangerous good under UN transport regulations
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Shipping Name: Finerenone
Environmental Hazards: Avoid accidental release during transport, prevent environmental exposure
Special Precautions: Keep containers tightly sealed, store according to regulatory guidance
U.S. Regulations: Not listed as hazardous under OSHA Hazard Communication Standard; controlled as a prescription pharmaceutical
EU Regulations: Not classified as hazardous under CLP Regulation EC 1272/2008
WHMIS (Canada): Not classified
REACH: Not registered, only available for R&D or clinical use via specific licenses
Other Regulations: Check for national regulations relating to pharmaceuticals, workplace safety, and environmental discharge
