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Material Safety Data Sheet (MSDS) – Fenoprofen Calcium

Identification

Product Name: Fenoprofen Calcium
Chemical Formula: C30H26CaN2O8
CAS Number: 52295-10-8
Intended Use: Analgesic, anti-inflammatory drug for pharmaceutical manufacturing
Manufacturer: [Company Name, Address, Emergency Contact Information]

Hazard Identification

Classification: Nonsteroidal Anti-Inflammatory Drug (NSAID), hazardous upon ingestion and inhalation in large doses,
Label Elements: Harmful if swallowed, may cause skin and eye irritation, harmful to aquatic life
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, has risk of organ damage with repeated exposure
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, avoid release to the environment, wear protective gloves and eye protection

Composition / Information on Ingredients

Chemical Identity: Fenoprofen Calcium
Percent by Weight: 100% active substance in pure form, excipients possible if formulated
Impurities and Additives: Not relevant in pure grade, pharmaceutical forms may include lactose, starch, magnesium stearate as inactive ingredients
Molecular Weight: 558.63 g/mol

First Aid Measures

Inhalation: Move exposed person to fresh air, seek medical help if breathing turns difficult or if symptoms develop
Skin Contact: Wash with soap and plenty of water, remove any contaminated clothing, medical attention only if irritation persists
Eye Contact: Rinse thoroughly with water for fifteen minutes, lift eyelids to ensure removal, get medical help if discomfort remains
Ingestion: Do not induce vomiting, rinse mouth with water, seek immediate medical assistance
Notes for Physicians: Symptomatic and supportive treatment, monitor for signs of gastrointestinal bleeding or kidney dysfunction

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray
Fire Hazards: May produce toxic fumes of carbon oxides, nitrogen oxides and calcium oxides under fire conditions
Firefighter Protection: Use full protective gear, including self-contained breathing apparatus, prevent runoff into drains or waterways
Unusual Combustion Products: Combustion releases dense smoke and hazardous decomposition fumes, which can irritate the respiratory tract

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, laboratory coat and particulate respirator, avoid dust formation
Spill Cleanup Methods: Sweep up material using tools to minimize dust, place in suitable labelled waste container, wash spill area with water
Environmental Precautions: Prevent spillage from entering soil, drain, or aquatic environment, notify proper authorities in case of large release
Containment: Use inert absorbent if mixed with liquids, handle in well-ventilated areas

Handling and Storage

Handling: Use engineering controls to minimize exposure, avoid direct contact with skin and eyes, employ dust extraction
Storage Conditions: Store in tightly closed containers in a cool, dry, ventilated area away from sunlight, acids, and incompatible substances
Incompatibilities: Keep separate from strong oxidizers and acids
Hygiene Practices: Wash hands after handling, do not eat or drink during use, keep containers sealed when not in use

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation required at points of dust generation, use enclosures during handling
Occupational Exposure Limits: No established specific occupational exposure limits for Fenoprofen Calcium; minimize exposure as a precaution
Respiratory Protection: Wear NIOSH-approved respirator if airborne dust exceeds comfort levels
Skin Protection: Use chemical-resistant gloves (nitrile or neoprene recommended), wear long-sleeved laboratory coat
Eye/Face Protection: Chemical safety goggles
General Safety: Use in accordance with safe laboratory practices and with easy access to eyewash stations and safety showers

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or practically odorless
Melting Point: 215-220 °C
Solubility: Sparingly soluble in water, soluble in ethanol
pH: Not applicable in solid form
Boiling Point: Not applicable
Vapor Pressure: Not determined
Density: Approximately 1.4 g/cm³
Partition Coefficient (Log P): Estimated 3.1 (octanol/water)
Other Properties: Stable under recommended storage conditions, non-volatile at room temperature

Stability and Reactivity

Chemical Stability: Stable under standard handling and storage conditions
Hazardous Reactions: Does not undergo dangerous reactions under normal use
Conditions to Avoid: Exposure to air, moisture, heat, strong acid or oxidizers
Decomposition Products: Yields toxic gases including carbon monoxide, carbon dioxide, calcium oxides and nitrogen oxides during combustion or decomposition
Polymerization: Not anticipated under standard conditions

Toxicological Information

Acute Toxicity: May cause mild to moderate irritation to gastrointestinal tract, possible effects on liver and kidneys at high exposures
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: Gastrointestinal upset, drowsiness, headaches, elevated creatinine, allergic skin reactions
Chronic Exposure Risks: Chronic use linked to gastrointestinal ulcers, kidney dysfunction, possible bleeding events
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Other Effects: Fenoprofen Calcium may trigger asthma symptoms or allergic reactions in sensitized individuals

Ecological Information

Ecotoxicity: Toxic to aquatic life in high concentrations, may persist in the environment
Mobility in Soil: Low mobility expected based on low solubility
Bioaccumulation: Potential exists due to moderate Log P
Persistence and Degradability: Not readily biodegradable
Other Environmental Hazards: Do not allow material or contaminated water from cleaning to flow into waterways or soil

Disposal Considerations

Waste Handling: Dispose as hazardous pharmaceutical waste according to local regulations
Container Disposal: Rinse and offer clean containers for recycling if permitted, otherwise dispose with chemical waste
Special Precautions: Do not flush to drain or mix with general waste, follow institutional, regional, and national hazardous waste procedures, use authorized chemical waste facility 

Transport Information

UN Number: Not regulated for transport if in small, packaged quantities
Transport Hazard Class: Not classified as dangerous under most transport regulations
Packing Group: Not assigned
Special Precautions for User: Protect from physical damage, moisture, incompatible substances, use secondary containment for bulk quantities
Additional Information: Follow local and national requirements for shipping pharmaceuticals 

Regulatory Information

Safety Regulations: Fenoprofen Calcium listed as prescription pharmaceutical in many regions, subject to regulations controlling distribution and use
OSHA: Not classified as hazardous chemical under OSHA Hazard Communication Standard
EU Regulation: Not classified as dangerous for supply (not subject to CLP Regulation), local requirements for pharmaceutical handling apply
Environmental Regulations: Subject to national and local waste disposal and emission control guidelines
Other Standards: Product quality and use governed by pharmacopeia and Good Manufacturing Practice standards