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Product Name: Fenbufen
Synonyms: 4-Biphenylacetic acid, 2-(4-biphenylyl)propionic acid
Chemical Formula: C16H14O2
CAS Number: 36330-85-5
Intended Use: Pharmaceutical, laboratory research
Supplier Details: Manufacturer and distributor contact, address, and emergency phone provided upon request
Globally Harmonized System Classification: Eye irritation (Category 2), Skin irritation (Category 2), Specific target organ toxicity (single exposure Category 3)
Labeling Elements: Warning symbol (exclamation mark), Hazard statements such as "Causes skin and eye irritation," "May cause respiratory irritation"
Potential Health Effects: Eyes—irritation, redness; Skin—redness, irritation; Inhalation—coughing, respiratory distress; Ingestion—gastric upset
Routes of Exposure: Skin, eyes, respiratory tract
Chemical Name: Fenbufen
CAS Number: 36330-85-5
Concentration: Pure compound, typically supplied at >98% purity
Impurities: Trace residual solvents, synthesis byproducts (full analytical report available upon request)
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, do not rub eyes, consult medical attention immediately
Skin Contact: Remove contaminated clothing, rinse skin with soap and water, seek medical advice for persistent symptoms
Inhalation: Move person to fresh air, keep at rest, provide artificial respiration if necessary, seek medical help if symptoms persist
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Special Hazards: Heating or fire can produce hazardous and irritating fumes including carbon oxides
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear
Advice for Firefighters: Avoid inhaling combustion gases, control run-off from firefighting to prevent entry into waterways or drains
Personal Precautions: Wear suitable gloves, eye/face protection, and mask to avoid dust exposure
Environmental Precautions: Prevent further leakage or spillage if safe, do not let residue enter drains, waterways, or soil
Containment Methods: Collect spilled material using dustless methods with non-sparking tools, place in suitable containers for disposal
Clean-up: Wash spill area with water and detergent after material removal, ventilate the area
Safe Handling: Avoid breathing dust, avoid contact with skin, eyes, clothing; use in well-ventilated areas, employ dust control technology
Safe Storage: Store tightly closed in original container in a cool, dry, well-ventilated area, protected from light, moisture, and incompatible substances
Incompatibles: Strong oxidizing agents, strong acids
Hygiene Practices: Wash hands thoroughly after handling, do not eat, drink or smoke during handling
Engineering Controls: Use chemical fume hood or similar engineering controls for laboratory use, ensure eyewash stations and safety showers nearby
Personal Protective Equipment (PPE): Chemical-resistant gloves, safety goggles or face shield, laboratory coat or apron, appropriate respirator if dust forms
Exposure Limits: No established occupational exposure limit for Fenbufen, general nuisance dust threshold applies (e.g., OEL for particulates: 10 mg/m³ total dust)
Environmental Controls: Avoid environmental release by using closed systems and best-practice waste management
Appearance: White or off-white crystalline powder
Odor: Odorless
Molecular Weight: 238.29 g/mol
Melting Point: 173 – 176°C
Boiling Point: Not applicable (decomposes)
Solubility: Sparingly soluble in water, freely soluble in organic solvents like DMSO, ethanol
pH: Not applicable (solid substance)
Vapor Pressure: Not determined
Partition Coefficient (log P): 4.6
Flash Point: Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 200°C
Chemical Stability: Stable under recommended conditions of storage and handling
Conditions to Avoid: Moisture, light, excessive heat
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, irritant fumes
Hazardous Reactions: Does not undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg; evidence from animal studies supports low acute toxicity
Skin Corrosion/Irritation: Causes moderate skin irritation based on animal studies
Eye Damage/Irritation: Provokes irritation and redness; not classified as severely damaging
Respiratory Sensitization: May cause respiratory system irritation and coughing when inhaled
Chronic Effects: Animal studies indicate possible liver and kidney effects at high repeated doses, not classified as a human carcinogen
Mutagenicity: Negative in standard mutagenicity assays
Additional Effects: Prolonged skin contact may worsen irritation, sensitive individuals should monitor for allergic responses
Ecotoxicity: Data limited, possible adverse effect on aquatic life based on structural similarity to other NSAIDs
Persistence and Degradability: Poorly biodegradable under environmental conditions
Bioaccumulative Potential: Moderate potential based on log P, unlikely to biomagnify significantly
Mobility in Soil: Limited information, tends to adsorb to soil particles
Other Adverse Effects: Prevent uncontrolled environmental release, avoid contamination of surface waters
Waste Method: Dispose of surplus material and waste in accordance with local, regional, and national regulations for hazardous or pharmaceutical waste
Packaging Disposal: Contaminated packaging must go to approved waste disposal facilities, minimize handling of empty containers
Environmental Precaution: Prevent disposal via sewer or in general refuse, consult appropriate environmental authorities before disposal
UN Number: Not assigned for this compound
UN Proper Shipping Name: Not regulated under major international transport codes (ADR/RID, IMDG, IATA)
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not assigned
Special Precautions: Avoid uncontrolled exposure to dust during transport, keep packaging intact and labeled
OSHA Status: Not listed as hazardous under US OSHA regulations
TSCA / DSL Listing: Consult compliance team for up-to-date status; not universally listed
SARA Title III: Not subject to specific reporting requirements
EU Classification: Not classified as a dangerous substance according to EU regulations, refer to REACH for additional details
Other Regulations: Observe all chemical hygiene and safety guidance relevant to local, state, and national compliance bodies
