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Product Name: Febantel
Chemical Name: N-(2-methoxy-5-nitrophenyl)-3-butanamido-2-benzimidazole methanone
Synonyms: Benzimidazole carbamate compound
CAS Number: 58306-30-2
Recommended Use: Veterinary anthelmintic, used for controlling gastrointestinal parasites
Manufacturer/Distributor: Veterinary pharmaceutical suppliers, animal health companies
Contact Information: Emergency phone numbers provided through the specific supplier or local poison control centers; refer to company directory for technical support
GHS Classification: Acute toxicity – Oral, Category 4; Specific target organ toxicity (single exposure), Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes eye irritation, causes mild skin irritation, may cause respiratory irritation
Precautionary Statements: Wash hands thoroughly after handling, avoid breathing dust, do not eat or drink when using this product, wear protective gloves and eye protection
Potential Health Effects: Can cause nausea, vomiting, dizziness, and gastrointestinal discomfort in large quantities; possible irritation to eyes and skin on direct contact
Environmental Hazards: Toxic to aquatic life with long lasting effects; avoid release into environment
Substance: Febantel
Chemical Formula: C20H22N4O6
Concentration: Pure product typically contains Febantel at or above 97%
Impurities: Minor organic process byproducts less than 2%, inactive binder excipients for commercial formulations, and possible trace solvents
Additives: None for technical grade; commercial products may contain fillers, binders, or dispersants detailed in product-specific inserts
Inhalation: Move to fresh air, monitor for breathing difficulty, seek medical attention if cough or soreness persists
Skin Contact: Remove contaminated clothing, wash affected skin with soap and water, medical advice recommended for persistent irritation
Eye Contact: Rinse immediately with gentle stream of clean water for at least 15 minutes, consult healthcare professional if redness or pain continues
Ingestion: Rinse mouth, drink small amount of water if conscious, do not induce vomiting, call poison control center or seek physician attention, provide material label if available
Notes for Healthcare Providers: Supportive care preferred, treat symptomatically, no specific antidote known; watch for allergic reaction or respiratory complication
Suitable Extinguishing Media: Use dry chemical, foam, CO2 or water spray for small fires; water mist or fog for large fires
Specific Hazards from Fire: This compound does not burn easily but elevated temperatures may create hazardous decomposition products including oxides of nitrogen and carbon
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing recommended; limit exposure to combustion gases
Advice for Firefighters: Move containers away from fire if it can be done without risk; dike runoff from fire control for later disposal; avoid inhalation of fumes
Personal Precautions: Use personal protective equipment, ensure adequate ventilation, prevent dust formation
Environmental Precautions: Do not allow to enter drains, surface water or soil
Containment: Collect spilled material with non-reactive absorbent (sand, earth, or commercial spill kit), transfer to labelled waste container
Cleanup Methods: Vacuum up or sweep up to minimize dust; clean spill area thoroughly with water and detergent
Disposal: Dispose as hazardous waste according to local regulations; avoid contamination with municipal refuse
Safe Handling: Handle only in well-ventilated areas, avoid skin and eye contact, do not breathe dust, practice good hygiene before eating, drinking or smoking
Storage Conditions: Store in tightly closed original container, cool and dry environment, protected from direct sunlight and moisture
Incompatible Materials: Keep away from strong acids, strong bases, oxidizers; prevent prolonged storage with food or animal feed
Special Requirements: Access to eye wash stations and safety showers in work area recommended, segregate from incompatible substances
Engineering Controls: Use process enclosures, local exhaust ventilation or general dilution ventilation to control airborne exposure
Exposure Limits: No exposure limits specifically established for Febantel but minimize dust as for nuisance particulates; consult local guidelines
Personal Protective Equipment (PPE): Use chemical-resistant gloves, safety goggles, lab coat or coverall, dust mask or particulate filter respirator approved for use
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing and wash before reuse, avoid direct hand to face contact
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic
Odor Threshold: Not available
pH: Insoluble in water; disperses slightly with mechanical agitation
Melting Point: 178–180°C
Boiling Point: Not determined; decomposes before boiling
Flash Point: Non-flammable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible
Relative Density: Approximately 1.4 g/cm³
Solubility: Practically insoluble in water; slightly soluble in ethanol, methanol
Partition Coefficient (log Kow): Estimated 1.8
Auto-ignition Temperature: Not self-igniting under standard conditions
Decomposition Temperature: Decomposes above melting point, releases toxic gases
Viscosity: Not applicable
Chemical Stability: Stable under normal storage and handling conditions, sensitive to high heat and strong light
Reactivity: Does not react with most materials under ambient conditions
Possibility of Hazardous Reactions: No significant reactivity under recommended use; avoid strong oxidizers
Conditions to Avoid: Excessive heat, open flame, direct sunlight, sources of ignition, high humidity
Incompatible Materials: Concentrated mineral acids, strong alkalis, oxidizing agents
Decomposition Products: At high temperatures produces oxides of nitrogen, carbon, and potentially toxic benzimidazole derivatives
Acute Toxicity: Oral LD50 (rat): 1800 mg/kg; considered low acute toxicity
Skin Corrosion/Irritation: Slightly irritating to skin based on animal studies
Serious Eye Damage/Irritation: Mild to moderate eye irritant in direct contact
Respiratory/Skin Sensitization: Not a known respiratory or skin sensitizer, though individual reactions possible
Chronic Effects: Prolonged or repeated exposure may cause mild liver effects in experimental models
Mutagenicity/Carcinogenicity: Not classed as mutagenic or carcinogenic; limited data in long-term studies
Reproductive Toxicity: No evidence of reproductive toxicity at therapeutic doses reported in veterinary practice
Specific Target Organ Toxicity: High oral doses may impact liver function in laboratory rodents
Aspiration Hazard: Not classified for aspiration
Ecotoxicity: Toxic to aquatic organisms, low LC50 values for fish and invertebrates; chronic exposure can harm aquatic life
Persistence and Degradability: Moderately persistent; slow biodegradation under natural conditions; parent compound remains active for weeks in soil and water
Bioaccumulative Potential: Moderate bioconcentration expected due to lipophilic character
Mobility in Soil: Binds to organic matter in soil, moderate leaching potential in sandy soils
Other Adverse Effects: Accumulation in sediment can disrupt local ecosystems; minimize contamination of water courses or drains
Waste Treatment Methods: Dispose of product, contaminated packaging, and clean-up materials through licensed waste management company
Disposal of Unused Product: Incinerate in controlled facility if possible; follow local environmental regulations
Contaminated Packaging: Rinse containers thoroughly before recycling or discarding; treat rinsate as chemical waste
Special Precautions: Avoid release to environment, keep away from food and animal feed during discarding process
Disposal Regulations: Adhere to local, state, and national environmental and hazardous waste guidelines
UN Number: Not regulated as dangerous for road, rail, sea, or air transport in most jurisdictions
Proper Shipping Name: Febantel or as per specific commercial formulation
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Contains substances harmful to aquatic life; caution to prevent container rupture during transit
Special Precautions: Secure packaging to prevent breakage or spillage, transport with documentation describing contents for customs and emergency response
Regulatory Notes: Some countries require export notification for veterinary pharmaceuticals
Safety, Health and Environmental Regulations: Covered under veterinary pharmaceutical registration acts and pesticide control agencies in many nations; no universal occupational exposure standard
Label Requirements: GHS-compliant warning labels for workplace containers; veterinary drugs regulated by prescription and distribution schemes
International Agreements: Not subject to major international chemical control conventions, but subject to Cartagena Protocol on Biosafety if genetically engineered production used
Global Inventory Listings: Registered in relevant chemical inventories in regions where veterinary use is authorized
Other Regulatory Considerations: Monitoring required for environmental residues, specific disposal protocols for large-scale facilities, review Material Safety Data Sheet with every batch received
