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Product Name: Ezetimibe Intermediate 2
Chemical Formula: C14H15F2NO3
Synonyms: Ezetimibe Intermediate C, 5-(4-Fluorophenyl)-3,4-dihydro-6-(1-methylethyl)-2(1H)-quinolinone
CAS Number: 163222-33-1
Manufacturing Use: Pharmaceutical synthesis, particularly as a building block for ezetimibe API production
Contact for Info: Safety and compliance offices at most manufacturing plants, or in-house EHS specialists
Classification: Irritant to eyes, skin, and respiratory tract; may be harmful if swallowed
Signal Word: Warning
Hazard Statements: Causes eye and skin irritation, dust may cause respiratory discomfort, toxic if inhaled or ingested in large amounts
Precautionary Statements: Wash hands thoroughly after handling, avoid breathing dust, use protective gear, keep away from ignition sources
Pictograms: Exclamation mark indicating irritant
Chemical Identity: 5-(4-Fluorophenyl)-3,4-dihydro-6-(1-methylethyl)-2(1H)-quinolinone
Concentration: Typically greater than 98% pure as supplied
Impurities: Trace byproducts from synthesis, less than 2% total by weight, usually screened for hazardous reactivity
Eye Contact: Flush eyes with water for at least 15 minutes, remove contact lenses, obtain medical help
Skin Contact: Wash affected area with soap and plenty of water, take off contaminated clothing, seek medical advice if irritation persists
Inhalation: Move person to fresh air, keep at rest, provide artificial respiration if needed, get medical attention if symptoms develop
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention, drink water only if conscious
Suitable Extinguishing Media: Use dry chemical powder, CO2, foam, or water spray; avoid strong water jets
Special Hazards: Combustion produces toxic fumes of nitrogen oxides and fluorinated compounds
Protective Equipment: Wear self-contained breathing apparatus and protective clothing; avoid inhaling smoke
Advice for Firefighters: Approach fire from upwind, use standard procedures for chemical fires, control runoff to prevent environmental contamination
Personal Precautions: Use personal protective equipment, keep unprotected persons away, ventilate area
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid discharge into drains, surface water, or soil
Cleanup Methods: Collect spillage mechanically, place in suitable containers for disposal, clean area thoroughly with water and detergent, ventilate site
Handling: Work in a well-ventilated area, wear protective gloves and safety goggles, reduce dust formation, avoid contact with skin and eyes, never eat or drink while handling
Storage: Store in tightly sealed containers in a cool, dry, and well-ventilated area, segregate from oxidizers and strong acids, clearly label containers, protect from moisture and heat, keep away from children and untrained personnel
Control Parameters: No established occupational exposure limits, reasonable precautions based on irritant nature
Engineering Controls: Apply local exhaust ventilation, use process enclosures if available
Personal Protection: Chemical-resistant gloves, protective clothing, safety goggles, use a dust mask or respirator, wash hands before breaks and after handling, do not reuse contaminated clothing
Appearance: Off-white to pale yellow crystalline solid
Odor: Faint, not distinctive
Melting Point: 110-115°C
Boiling Point: Not applicable, decomposes
Solubility: Low solubility in water, soluble in organic solvents like DMSO and DMF
Molecular Weight: 267.28
Vapor Pressure: Negligible at ambient temperature
Stability: Stable under recommended storage conditions, sensitive to moisture
Chemical Stability: Stable under normal temperatures and pressures, moisture sensitive
Hazardous Reactions: None under normal conditions; avoid mixing with strong oxidizing agents and acids
Decomposition Products: Hazardous gases such as nitrogen oxides and hydrogen fluoride under fire conditions
Incompatible Materials: Strong oxidizers, acids, bases, water (in case of storage or spillage)
Acute Toxicity: Not fully assessed, low to moderate oral and dermal toxicity suggested by synthetic analogs
Irritation: Causes eye and skin irritation, respiratory irritation if inhaled as a fine powder
Chronic Effects: Long-term exposure data lacking, but unnecessary chronic exposure is best avoided
Sensitization: No data available; handle with caution to reduce possibility
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Ecotoxicity: Limited data, not known to be highly toxic to aquatic life at low concentrations, but prudent disposal practices matter
Persistence and Degradability: Not readily biodegradable, potential for bioaccumulation not ruled out
Mobility in Soil: Expected to have low mobility, but spills could lead to localized contamination
Precautions: Prevent entry into waterways, soil, and drains
Waste Treatment Methods: Dispose of through licensed hazardous waste contractor; incineration recommended for large quantities, use official chemical disposal containers for small amounts
Contaminated Packaging: Triple rinse empty containers, crush, and offer for disposal in accordance with local regulations
Legal Disposal: Follow local, regional, and national rules for hazardous chemical waste
UN Number: Not assigned, not regulated under standard international shipping codes for small research quantities
Transport Hazard Class: Not classified as dangerous goods
Packing Group: None
Special Precautions: Secure packaging to prevent spillage, include a copy of the safety data sheet with all shipments, label as “for chemical research” or for intended industrial use only
Inventories: Not listed on most major chemical inventories due to intermediate status
Labeling Requirements: Must follow GHS and OSHA labeling rules, including hazard communication
TSCA Status: For research use, typically covered under R&D exemptions
Other Controls: Subject to workplace chemical handling laws, duty to report significant releases, responsibility to update safety procedures as more data becomes available
